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Fusion gene ID: 10471 |
FusionGeneSummary for DPH6_SHC4 |
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Fusion gene information | Fusion gene name: DPH6_SHC4 | Fusion gene ID: 10471 | Hgene | Tgene | Gene symbol | DPH6 | SHC4 | Gene ID | 89978 | 399694 |
Gene name | diphthamine biosynthesis 6 | SHC adaptor protein 4 | |
Synonyms | ATPBD4 | RaLP|SHCD | |
Cytomap | 15q14 | 15q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | diphthine--ammonia ligaseATP binding domain 4ATP-binding domain-containing protein 4DPH6 homologdiphthamide synthasediphthamide synthetaseprotein DPH6 homolog | SHC-transforming protein 4SH2 domain protein C4SHC (Src homology 2 domain containing) family, member 4SHC-transforming protein DhShcDrai-like proteinsrc homology 2 domain-containing-transforming protein C4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q7L8W6 | Q6S5L8 | |
Ensembl transtripts involved in fusion gene | ENST00000560386, ENST00000256538, ENST00000440392, | ENST00000332408, ENST00000396535, ENST00000537958, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 2=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DPH6 [Title/Abstract] AND SHC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | COAD | TCGA-CM-5348-01A | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000560386 | ENST00000332408 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
intron-3CDS | ENST00000560386 | ENST00000396535 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
intron-3CDS | ENST00000560386 | ENST00000537958 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
Frame-shift | ENST00000256538 | ENST00000332408 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
Frame-shift | ENST00000256538 | ENST00000396535 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
Frame-shift | ENST00000256538 | ENST00000537958 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
Frame-shift | ENST00000440392 | ENST00000332408 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
Frame-shift | ENST00000440392 | ENST00000396535 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
Frame-shift | ENST00000440392 | ENST00000537958 | DPH6 | chr15 | 35838320 | - | SHC4 | chr15 | 49127219 | - |
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FusionProtFeatures for DPH6_SHC4 |
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Hgene | Tgene |
DPH6 | SHC4 |
Amidase that catalyzes the last step of diphthamidebiosynthesis using ammonium and ATP. Diphthamide biosynthesisconsists in the conversion of an L-histidine residue in thetranslation elongation factor (EEF2) to diphthamide (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:23169644}. | Activates both Ras-dependent and Ras-independentmigratory pathways in melanomas. Contributes to the early phasesof agrin-induced tyrosine phosphorylation of CHRNB1.{ECO:0000269|PubMed:17409413}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DPH6_SHC4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DPH6_SHC4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DPH6 | ATP2B2, KIAA1919, SLC18A1, ADAMTS4, S100A8, GRPR, PTGIR, TMCO3, C5AR2, SMARCB1 | SHC4 | EGFR, GRB2, NBEA, GAREM, CHUK, AMD1, SHC3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DPH6_SHC4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPH6_SHC4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |