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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10471

FusionGeneSummary for DPH6_SHC4

check button Fusion gene summary
Fusion gene informationFusion gene name: DPH6_SHC4
Fusion gene ID: 10471
HgeneTgene
Gene symbol

DPH6

SHC4

Gene ID

89978

399694

Gene namediphthamine biosynthesis 6SHC adaptor protein 4
SynonymsATPBD4RaLP|SHCD
Cytomap

15q14

15q21.1

Type of geneprotein-codingprotein-coding
Descriptiondiphthine--ammonia ligaseATP binding domain 4ATP-binding domain-containing protein 4DPH6 homologdiphthamide synthasediphthamide synthetaseprotein DPH6 homologSHC-transforming protein 4SH2 domain protein C4SHC (Src homology 2 domain containing) family, member 4SHC-transforming protein DhShcDrai-like proteinsrc homology 2 domain-containing-transforming protein C4
Modification date2018052320180523
UniProtAcc

Q7L8W6

Q6S5L8

Ensembl transtripts involved in fusion geneENST00000560386, ENST00000256538, 
ENST00000440392, 
ENST00000332408, 
ENST00000396535, ENST00000537958, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 2=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DPH6 [Title/Abstract] AND SHC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-CM-5348-01ADPH6chr15

35838320

-SHC4chr15

49127219

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000560386ENST00000332408DPH6chr15

35838320

-SHC4chr15

49127219

-
intron-3CDSENST00000560386ENST00000396535DPH6chr15

35838320

-SHC4chr15

49127219

-
intron-3CDSENST00000560386ENST00000537958DPH6chr15

35838320

-SHC4chr15

49127219

-
Frame-shitENST00000256538ENST00000332408DPH6chr15

35838320

-SHC4chr15

49127219

-
Frame-shitENST00000256538ENST00000396535DPH6chr15

35838320

-SHC4chr15

49127219

-
Frame-shitENST00000256538ENST00000537958DPH6chr15

35838320

-SHC4chr15

49127219

-
Frame-shitENST00000440392ENST00000332408DPH6chr15

35838320

-SHC4chr15

49127219

-
Frame-shitENST00000440392ENST00000396535DPH6chr15

35838320

-SHC4chr15

49127219

-
Frame-shitENST00000440392ENST00000537958DPH6chr15

35838320

-SHC4chr15

49127219

-

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FusionProtFeatures for DPH6_SHC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPH6

Q7L8W6

SHC4

Q6S5L8

Amidase that catalyzes the last step of diphthamidebiosynthesis using ammonium and ATP. Diphthamide biosynthesisconsists in the conversion of an L-histidine residue in thetranslation elongation factor (EEF2) to diphthamide (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:23169644}. Activates both Ras-dependent and Ras-independentmigratory pathways in melanomas. Contributes to the early phasesof agrin-induced tyrosine phosphorylation of CHRNB1.{ECO:0000269|PubMed:17409413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DPH6_SHC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DPH6_SHC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DPH6ATP2B2, KIAA1919, SLC18A1, ADAMTS4, S100A8, GRPR, PTGIR, TMCO3, C5AR2, SMARCB1SHC4EGFR, GRB2, NBEA, GAREM, CHUK, AMD1, SHC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DPH6_SHC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DPH6_SHC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource