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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10442

FusionGeneSummary for DOPEY2_ELF2

check button Fusion gene summary
Fusion gene informationFusion gene name: DOPEY2_ELF2
Fusion gene ID: 10442
HgeneTgene
Gene symbol

DOPEY2

ELF2

Gene ID

9980

1998

Gene namedopey family member 2E74 like ETS transcription factor 2
Synonyms21orf5|C21orf5EU32|NERF|NERF-1A|NERF-1B|NERF-1a,b|NERF-2
Cytomap

21q22.12

4q31.1

Type of geneprotein-codingprotein-coding
Descriptionprotein dopey-2homolog of yeast DOP1ETS-related transcription factor Elf-2E74-like factor 2 (ets domain transcription factor)ets family transcription factor ELF2Cnew Ets-related factor
Modification date2018052320180523
UniProtAcc

Q9Y3R5

Q15723

Ensembl transtripts involved in fusion geneENST00000399151, ENST00000492760, 
ENST00000394235, ENST00000379549, 
ENST00000379550, ENST00000265495, 
ENST00000358635, ENST00000510408, 
ENST00000515489, 
Fusion gene scores* DoF score7 X 7 X 7=3432 X 2 X 2=8
# samples 92
** MAII scorelog2(9/343*10)=-1.93021166984314
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: DOPEY2 [Title/Abstract] AND ELF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneELF2

GO:0006357

regulation of transcription by RNA polymerase II

8756667

TgeneELF2

GO:0045893

positive regulation of transcription, DNA-templated

8756667


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5525-01ADOPEY2chr21

37572799

+ELF2chr4

139983211

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000399151ENST00000394235DOPEY2chr21

37572799

+ELF2chr4

139983211

-
Frame-shiftENST00000399151ENST00000379549DOPEY2chr21

37572799

+ELF2chr4

139983211

-
Frame-shiftENST00000399151ENST00000379550DOPEY2chr21

37572799

+ELF2chr4

139983211

-
Frame-shiftENST00000399151ENST00000265495DOPEY2chr21

37572799

+ELF2chr4

139983211

-
Frame-shiftENST00000399151ENST00000358635DOPEY2chr21

37572799

+ELF2chr4

139983211

-
Frame-shiftENST00000399151ENST00000510408DOPEY2chr21

37572799

+ELF2chr4

139983211

-
5CDS-intronENST00000399151ENST00000515489DOPEY2chr21

37572799

+ELF2chr4

139983211

-
intron-3CDSENST00000492760ENST00000394235DOPEY2chr21

37572799

+ELF2chr4

139983211

-
intron-3CDSENST00000492760ENST00000379549DOPEY2chr21

37572799

+ELF2chr4

139983211

-
intron-3CDSENST00000492760ENST00000379550DOPEY2chr21

37572799

+ELF2chr4

139983211

-
intron-3CDSENST00000492760ENST00000265495DOPEY2chr21

37572799

+ELF2chr4

139983211

-
intron-3CDSENST00000492760ENST00000358635DOPEY2chr21

37572799

+ELF2chr4

139983211

-
intron-3CDSENST00000492760ENST00000510408DOPEY2chr21

37572799

+ELF2chr4

139983211

-
intron-intronENST00000492760ENST00000515489DOPEY2chr21

37572799

+ELF2chr4

139983211

-

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FusionProtFeatures for DOPEY2_ELF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DOPEY2

Q9Y3R5

ELF2

Q15723

May be involved in protein traffic between late Golgiand early endosomes. {ECO:0000250}. Isoform 1 transcriptionally activates the LYN and BLKpromoters and acts synergistically with RUNX1 to transactivate theBLK promoter. Isoform 2 may function in repression of RUNX1-mediatedtransactivation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DOPEY2_ELF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DOPEY2_ELF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DOPEY2EGFR, SDC2, LAMP3ELF2RUNX1, ZBTB32, BAP1, ELAVL1, APP, HSPBP1, PSME3, SPINT2, PRPS1, PSMC3, HIST1H2BG, HIST1H3A, DYNLT1, IKZF5, NFATC2IP, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DOPEY2_ELF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DOPEY2_ELF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneELF2C3495559Juvenile arthritis1CTD_human