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Fusion gene ID: 10424 |
FusionGeneSummary for DOCK9_SPACA7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK9_SPACA7 | Fusion gene ID: 10424 | Hgene | Tgene | Gene symbol | DOCK9 | SPACA7 | Gene ID | 23348 | 122258 |
| Gene name | dedicator of cytokinesis 9 | sperm acrosome associated 7 | |
| Synonyms | ZIZ1|ZIZIMIN1 | C13orf28 | |
| Cytomap | 13q32.3 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 9cdc42 guanine nucleotide exchange factor zizimin-1zizimin-1 | sperm acrosome-associated protein 7protein SPACA7 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q9BZ29 | Q96KW9 | |
| Ensembl transtripts involved in fusion gene | ENST00000376460, ENST00000339416, ENST00000448493, ENST00000442173, ENST00000461998, | ENST00000283550, ENST00000375699, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DOCK9 [Title/Abstract] AND SPACA7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-69-7979-01A | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000376460 | ENST00000283550 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| Frame-shift | ENST00000376460 | ENST00000375699 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| Frame-shift | ENST00000339416 | ENST00000283550 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| Frame-shift | ENST00000339416 | ENST00000375699 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| In-frame | ENST00000448493 | ENST00000283550 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| In-frame | ENST00000448493 | ENST00000375699 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| Frame-shift | ENST00000442173 | ENST00000283550 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| Frame-shift | ENST00000442173 | ENST00000375699 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| intron-3CDS | ENST00000461998 | ENST00000283550 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
| intron-3CDS | ENST00000461998 | ENST00000375699 | DOCK9 | chr13 | 99532801 | - | SPACA7 | chr13 | 113086758 | + |
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FusionProtFeatures for DOCK9_SPACA7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK9 | SPACA7 |
| Involved in fertilization. Seems not to play a directrole in sperm-egg binding or gamete fusion.{ECO:0000250|UniProtKB:Q9D2S4}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DOCK9_SPACA7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DOCK9_ENST00000448493_chr13_99532801_-_SPACA7_ENST00000283550_chr13_113086758_+_1016aa MGCTTSVILFKGIRTVFERNCAYMCKQQGENNALEYTAYNWTKEDSELLISSWLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYD DFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSDWHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLG SQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQNNKVRRFAFELKMQDKSSY LLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDDEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLD FSSAEPEVKSFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSPALMNG SGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA RTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVNSSYIPTKQFETCSKTPIT FEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPE FYDEIKIELPTQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGP EIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAV NVTRVIIHVVAQCHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKKRIQRTLSMKIYPFWTKSFKI >In-frame_DOCK9_ENST00000448493_chr13_99532801_-_SPACA7_ENST00000375699_chr13_113086758_+_1016aa MGCTTSVILFKGIRTVFERNCAYMCKQQGENNALEYTAYNWTKEDSELLISSWLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYD DFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSDWHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLG SQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQNNKVRRFAFELKMQDKSSY LLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDDEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLD FSSAEPEVKSFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSPALMNG SGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA RTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVNSSYIPTKQFETCSKTPIT FEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPE FYDEIKIELPTQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGP EIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAV NVTRVIIHVVAQCHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKKRIQRTLSMKIYPFWTKSFKI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DOCK9_ENST00000448493_chr13_99532801_-_SPACA7_ENST00000283550_chr13_113086758_+_3050nt ATGGGTTGCACTACTAGTGTGATTCTGTTTAAAGGCATCCGCACCGTTTTTGAAAGAAACTGTGCTTATATGTGCAAACAGCAAGGAGAG AATAATGCCCTTGAATATACAGCATACAATTGGACAAAAGAAGATTCAGAACTATTGATCTCCTCCTGGCTGGCAAAGCCAAAGCTAATT GAGCCACTCGACTATGAAAATGTCATCGTCCAGAAGAAGACTCAGATCCTGAACGACTGTTTACGGGAGATGCTGCTCTTCCCTTACGAT GACTTTCAGACGGCCATCCTGAGACGACAGGGTCGATACATATGCTCAACAGTGCCTGCGAAGGCGGAAGAGGAAGCACAGAGCTTGTTT GTTACAGAGTGCATCAAAACCTATAACTCTGACTGGCATCTTGTGAACTATAAATATGAAGATTACTCAGGAGAGTTTCGACAGCTTCCG AACAAAGTGGTCAAGTTGGATAAACTTCCAGTTCATGTCTATGAAGTTGACGAGGAGGTCGACAAAGATGAGGATGCTGCCTCCCTTGGT TCCCAGAAGGGTGGGATCACCAAGCATGGCTGGCTGTACAAAGGCAACATGAACAGTGCCATCAGCGTGACCATGAGGTCATTTAAGAGA CGATTTTTCCACCTGATTCAACTTGGCGATGGATCCTATAATTTGAATTTTTATAAAGATGAAAAGATCTCCAAAGAACCAAAAGGATCA ATATTTCTGGATTCCTGTATGGGTGTCGTTCAGAACAACAAAGTCAGGCGTTTTGCTTTTGAGCTCAAGATGCAGGACAAAAGTAGTTAT CTCTTGGCAGCAGACAGTGAAGTGGAAATGGAAGAATGGATCACAATTCTAAATAAGATCCTCCAGCTCAACTTTGAAGCTGCAATGCAA GAAAAGCGAAATGGCGACTCTCACGAAGATGATGAACAAAGCAAATTGGAAGGTTCTGGTTCCGGTTTAGATAGCTACCTGCCGGAACTT GCCAAGAGTGCAAGAGAAGCAGAAATCAAACTGAAAAGTGAAAGCAGAGTCAAACTTTTTTATTTGGACCCAGATGCCCAGAAGCTTGAC TTCTCATCAGCTGAGCCAGAAGTGAAGTCATTTGAAGAGAAGTTTGGAAAAAGGATCCTTGTCAAGTGCAATGATTTATCTTTCAATTTG CAATGCTGTGTTGCCGAAAATGAAGAAGGACCCACTACAAATGTTGAACCTTTCTTTGTTACTCTATCCCTGTTTGACATAAAATACAAC CGGAAGATTTCTGCCGATTTCCACGTAGACCTGAACCATTTCTCAGTGAGGCAAATGCTCGCCACCACGTCCCCGGCGCTGATGAATGGC AGTGGGCAGAGCCCATCTGTCCTCAAGGGCATCCTTCATGAAGCCGCCATGCAGTATCCGAAGCAGGGAATATTTTCAGTCACTTGTCCT CATCCAGATATATTTCTTGTGGCCAGAATTGAAAAAGTCCTTCAGGGGAGCATCACACATTGCGCTGAGCCATATATGAAAAGTTCAGAC TCTTCTAAGGTGGCCCAGAAGGTGCTGAAGAATGCCAAGCAGGCATGCCAAAGACTAGGACAGTATAGAATGCCATTTGCTTGGGCAGCA AGGACATTGTTTAAGGATGCATCTGGAAATCTTGACAAAAATGCCAGATTTTCTGCCATCTACAGGCAAGACAGCAATAAGCTATCCAAT GATGACATGCTCAAGTTACTTGCAGACTTTCGGAAACCTGAGAAGATGGCTAAGCTCCCAGTGATTTTAGGCAATCTAGACATTACAATT GATAATGTTTCCTCAGACTTCCCTAATTATGTTAATTCATCATACATTCCCACAAAACAATTTGAAACCTGCAGTAAAACTCCCATCACG TTTGAAGTGGAGGAATTTGTGCCCTGCATACCAAAACACACTCAGCCTTACACCATCTACACCAATCACCTTTACGTTTATCCTAAGTAC TTGAAATACGACAGTCAGAAGTCTTTTGCCAAGGCTAGAAATATTGCGATTTGCATTGAATTCAAAGATTCAGATGAGGAAGACTCTCAG CCCCTTAAGTGCATTTATGGCAGACCTGGTGGGCCAGTTTTCACAAGAAGCGCCTTTGCTGCAGTTTTACACCATCACCAAAACCCAGAA TTTTATGATGAGATTAAAATAGAGTTGCCCACTCAGCTGCATGAAAAGCACCACCTGTTGCTCACATTCTTCCATGTCAGCTGTGACAAC TCAAGTAAAGGAAGCACGAAGAAGAGGGATGTCGTTGAAACCCAAGTTGGCTACTCCTGGCTTCCCCTCCTGAAAGACGGAAGGGTGGTG ACAAGCGAGCAGCACATCCCGGTCTCGGCGAACCTTCCTTCGGGCTATCTTGGCTACCAGGAGCTTGGGATGGGCAGGCATTATGGTCCG GAAATTAAATGGGTAGATGGAGGCAAGCCACTGCTGAAAATTTCCACTCATCTGGTTTCTACAGTGTATACTCAGGATCAGCATTTACAT AATTTTTTCCAGTACTGTCAGAAAACCGAATCTGGAGCCCAAGCCTTAGGAAACGAACTTGTAAAGTACCTTAAGAGTCTGCATGCGATG GAAGGCCACGTGATGATCGCCTTCTTGCCCACTATCCTAAACCAGCTGTTCCGAGTCCTCACCAGAGCCACACAGGAAGAAGTCGCGGTT AACGTGACTCGGGTCATTATTCATGTGGTTGCCCAGTGCCATGAGGAAGGATTGGAGAGCCACTTGAGGTCATATGTTAAGTACGCGTAT AAGGCTGAGCCATATGTTGCCTCTGAATACAAGACAGTGCATGAAGAACTGACCAAATCCATGACCACGATTCTCAAGCCTTCTGCCGAT TTCCTCACCAGCAACAAACTACTGAAGAAAAGAATTCAAAGAACACTCAGTATGAAAATCTATCCATTCTGGACCAAATCCTTCAAAATA >In-frame_DOCK9_ENST00000448493_chr13_99532801_-_SPACA7_ENST00000375699_chr13_113086758_+_3050nt ATGGGTTGCACTACTAGTGTGATTCTGTTTAAAGGCATCCGCACCGTTTTTGAAAGAAACTGTGCTTATATGTGCAAACAGCAAGGAGAG AATAATGCCCTTGAATATACAGCATACAATTGGACAAAAGAAGATTCAGAACTATTGATCTCCTCCTGGCTGGCAAAGCCAAAGCTAATT GAGCCACTCGACTATGAAAATGTCATCGTCCAGAAGAAGACTCAGATCCTGAACGACTGTTTACGGGAGATGCTGCTCTTCCCTTACGAT GACTTTCAGACGGCCATCCTGAGACGACAGGGTCGATACATATGCTCAACAGTGCCTGCGAAGGCGGAAGAGGAAGCACAGAGCTTGTTT GTTACAGAGTGCATCAAAACCTATAACTCTGACTGGCATCTTGTGAACTATAAATATGAAGATTACTCAGGAGAGTTTCGACAGCTTCCG AACAAAGTGGTCAAGTTGGATAAACTTCCAGTTCATGTCTATGAAGTTGACGAGGAGGTCGACAAAGATGAGGATGCTGCCTCCCTTGGT TCCCAGAAGGGTGGGATCACCAAGCATGGCTGGCTGTACAAAGGCAACATGAACAGTGCCATCAGCGTGACCATGAGGTCATTTAAGAGA CGATTTTTCCACCTGATTCAACTTGGCGATGGATCCTATAATTTGAATTTTTATAAAGATGAAAAGATCTCCAAAGAACCAAAAGGATCA ATATTTCTGGATTCCTGTATGGGTGTCGTTCAGAACAACAAAGTCAGGCGTTTTGCTTTTGAGCTCAAGATGCAGGACAAAAGTAGTTAT CTCTTGGCAGCAGACAGTGAAGTGGAAATGGAAGAATGGATCACAATTCTAAATAAGATCCTCCAGCTCAACTTTGAAGCTGCAATGCAA GAAAAGCGAAATGGCGACTCTCACGAAGATGATGAACAAAGCAAATTGGAAGGTTCTGGTTCCGGTTTAGATAGCTACCTGCCGGAACTT GCCAAGAGTGCAAGAGAAGCAGAAATCAAACTGAAAAGTGAAAGCAGAGTCAAACTTTTTTATTTGGACCCAGATGCCCAGAAGCTTGAC TTCTCATCAGCTGAGCCAGAAGTGAAGTCATTTGAAGAGAAGTTTGGAAAAAGGATCCTTGTCAAGTGCAATGATTTATCTTTCAATTTG CAATGCTGTGTTGCCGAAAATGAAGAAGGACCCACTACAAATGTTGAACCTTTCTTTGTTACTCTATCCCTGTTTGACATAAAATACAAC CGGAAGATTTCTGCCGATTTCCACGTAGACCTGAACCATTTCTCAGTGAGGCAAATGCTCGCCACCACGTCCCCGGCGCTGATGAATGGC AGTGGGCAGAGCCCATCTGTCCTCAAGGGCATCCTTCATGAAGCCGCCATGCAGTATCCGAAGCAGGGAATATTTTCAGTCACTTGTCCT CATCCAGATATATTTCTTGTGGCCAGAATTGAAAAAGTCCTTCAGGGGAGCATCACACATTGCGCTGAGCCATATATGAAAAGTTCAGAC TCTTCTAAGGTGGCCCAGAAGGTGCTGAAGAATGCCAAGCAGGCATGCCAAAGACTAGGACAGTATAGAATGCCATTTGCTTGGGCAGCA AGGACATTGTTTAAGGATGCATCTGGAAATCTTGACAAAAATGCCAGATTTTCTGCCATCTACAGGCAAGACAGCAATAAGCTATCCAAT GATGACATGCTCAAGTTACTTGCAGACTTTCGGAAACCTGAGAAGATGGCTAAGCTCCCAGTGATTTTAGGCAATCTAGACATTACAATT GATAATGTTTCCTCAGACTTCCCTAATTATGTTAATTCATCATACATTCCCACAAAACAATTTGAAACCTGCAGTAAAACTCCCATCACG TTTGAAGTGGAGGAATTTGTGCCCTGCATACCAAAACACACTCAGCCTTACACCATCTACACCAATCACCTTTACGTTTATCCTAAGTAC TTGAAATACGACAGTCAGAAGTCTTTTGCCAAGGCTAGAAATATTGCGATTTGCATTGAATTCAAAGATTCAGATGAGGAAGACTCTCAG CCCCTTAAGTGCATTTATGGCAGACCTGGTGGGCCAGTTTTCACAAGAAGCGCCTTTGCTGCAGTTTTACACCATCACCAAAACCCAGAA TTTTATGATGAGATTAAAATAGAGTTGCCCACTCAGCTGCATGAAAAGCACCACCTGTTGCTCACATTCTTCCATGTCAGCTGTGACAAC TCAAGTAAAGGAAGCACGAAGAAGAGGGATGTCGTTGAAACCCAAGTTGGCTACTCCTGGCTTCCCCTCCTGAAAGACGGAAGGGTGGTG ACAAGCGAGCAGCACATCCCGGTCTCGGCGAACCTTCCTTCGGGCTATCTTGGCTACCAGGAGCTTGGGATGGGCAGGCATTATGGTCCG GAAATTAAATGGGTAGATGGAGGCAAGCCACTGCTGAAAATTTCCACTCATCTGGTTTCTACAGTGTATACTCAGGATCAGCATTTACAT AATTTTTTCCAGTACTGTCAGAAAACCGAATCTGGAGCCCAAGCCTTAGGAAACGAACTTGTAAAGTACCTTAAGAGTCTGCATGCGATG GAAGGCCACGTGATGATCGCCTTCTTGCCCACTATCCTAAACCAGCTGTTCCGAGTCCTCACCAGAGCCACACAGGAAGAAGTCGCGGTT AACGTGACTCGGGTCATTATTCATGTGGTTGCCCAGTGCCATGAGGAAGGATTGGAGAGCCACTTGAGGTCATATGTTAAGTACGCGTAT AAGGCTGAGCCATATGTTGCCTCTGAATACAAGACAGTGCATGAAGAACTGACCAAATCCATGACCACGATTCTCAAGCCTTCTGCCGAT TTCCTCACCAGCAACAAACTACTGAAGAAAAGAATTCAAAGAACACTCAGTATGAAAATCTATCCATTCTGGACCAAATCCTTCAAAATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DOCK9_ENST00000448493_chr13_99532801_-_SPACA7_ENST00000283550_chr13_113086758_+_3301nt GACTGCTTGTCACGAAGATGGTACAGTGGGAGCCTGTTTCGGAAGAGCCAAGGAAGAGGATGTGGAAATGGAGTAGAGATTGCTAAAAAA CTGAACATCCACACCTTGGGGATGGGTTGCACTACTAGTGTGATTCTGTTTAAAGGCATCCGCACCGTTTTTGAAAGAAACTGTGCTTAT ATGTGCAAACAGCAAGGAGAGAATAATGCCCTTGAATATACAGCATACAATTGGACAAAAGAAGATTCAGAACTATTGATCTCCTCCTGG CTGGCAAAGCCAAAGCTAATTGAGCCACTCGACTATGAAAATGTCATCGTCCAGAAGAAGACTCAGATCCTGAACGACTGTTTACGGGAG ATGCTGCTCTTCCCTTACGATGACTTTCAGACGGCCATCCTGAGACGACAGGGTCGATACATATGCTCAACAGTGCCTGCGAAGGCGGAA GAGGAAGCACAGAGCTTGTTTGTTACAGAGTGCATCAAAACCTATAACTCTGACTGGCATCTTGTGAACTATAAATATGAAGATTACTCA GGAGAGTTTCGACAGCTTCCGAACAAAGTGGTCAAGTTGGATAAACTTCCAGTTCATGTCTATGAAGTTGACGAGGAGGTCGACAAAGAT GAGGATGCTGCCTCCCTTGGTTCCCAGAAGGGTGGGATCACCAAGCATGGCTGGCTGTACAAAGGCAACATGAACAGTGCCATCAGCGTG ACCATGAGGTCATTTAAGAGACGATTTTTCCACCTGATTCAACTTGGCGATGGATCCTATAATTTGAATTTTTATAAAGATGAAAAGATC TCCAAAGAACCAAAAGGATCAATATTTCTGGATTCCTGTATGGGTGTCGTTCAGAACAACAAAGTCAGGCGTTTTGCTTTTGAGCTCAAG ATGCAGGACAAAAGTAGTTATCTCTTGGCAGCAGACAGTGAAGTGGAAATGGAAGAATGGATCACAATTCTAAATAAGATCCTCCAGCTC AACTTTGAAGCTGCAATGCAAGAAAAGCGAAATGGCGACTCTCACGAAGATGATGAACAAAGCAAATTGGAAGGTTCTGGTTCCGGTTTA GATAGCTACCTGCCGGAACTTGCCAAGAGTGCAAGAGAAGCAGAAATCAAACTGAAAAGTGAAAGCAGAGTCAAACTTTTTTATTTGGAC CCAGATGCCCAGAAGCTTGACTTCTCATCAGCTGAGCCAGAAGTGAAGTCATTTGAAGAGAAGTTTGGAAAAAGGATCCTTGTCAAGTGC AATGATTTATCTTTCAATTTGCAATGCTGTGTTGCCGAAAATGAAGAAGGACCCACTACAAATGTTGAACCTTTCTTTGTTACTCTATCC CTGTTTGACATAAAATACAACCGGAAGATTTCTGCCGATTTCCACGTAGACCTGAACCATTTCTCAGTGAGGCAAATGCTCGCCACCACG TCCCCGGCGCTGATGAATGGCAGTGGGCAGAGCCCATCTGTCCTCAAGGGCATCCTTCATGAAGCCGCCATGCAGTATCCGAAGCAGGGA ATATTTTCAGTCACTTGTCCTCATCCAGATATATTTCTTGTGGCCAGAATTGAAAAAGTCCTTCAGGGGAGCATCACACATTGCGCTGAG CCATATATGAAAAGTTCAGACTCTTCTAAGGTGGCCCAGAAGGTGCTGAAGAATGCCAAGCAGGCATGCCAAAGACTAGGACAGTATAGA ATGCCATTTGCTTGGGCAGCAAGGACATTGTTTAAGGATGCATCTGGAAATCTTGACAAAAATGCCAGATTTTCTGCCATCTACAGGCAA GACAGCAATAAGCTATCCAATGATGACATGCTCAAGTTACTTGCAGACTTTCGGAAACCTGAGAAGATGGCTAAGCTCCCAGTGATTTTA GGCAATCTAGACATTACAATTGATAATGTTTCCTCAGACTTCCCTAATTATGTTAATTCATCATACATTCCCACAAAACAATTTGAAACC TGCAGTAAAACTCCCATCACGTTTGAAGTGGAGGAATTTGTGCCCTGCATACCAAAACACACTCAGCCTTACACCATCTACACCAATCAC CTTTACGTTTATCCTAAGTACTTGAAATACGACAGTCAGAAGTCTTTTGCCAAGGCTAGAAATATTGCGATTTGCATTGAATTCAAAGAT TCAGATGAGGAAGACTCTCAGCCCCTTAAGTGCATTTATGGCAGACCTGGTGGGCCAGTTTTCACAAGAAGCGCCTTTGCTGCAGTTTTA CACCATCACCAAAACCCAGAATTTTATGATGAGATTAAAATAGAGTTGCCCACTCAGCTGCATGAAAAGCACCACCTGTTGCTCACATTC TTCCATGTCAGCTGTGACAACTCAAGTAAAGGAAGCACGAAGAAGAGGGATGTCGTTGAAACCCAAGTTGGCTACTCCTGGCTTCCCCTC CTGAAAGACGGAAGGGTGGTGACAAGCGAGCAGCACATCCCGGTCTCGGCGAACCTTCCTTCGGGCTATCTTGGCTACCAGGAGCTTGGG ATGGGCAGGCATTATGGTCCGGAAATTAAATGGGTAGATGGAGGCAAGCCACTGCTGAAAATTTCCACTCATCTGGTTTCTACAGTGTAT ACTCAGGATCAGCATTTACATAATTTTTTCCAGTACTGTCAGAAAACCGAATCTGGAGCCCAAGCCTTAGGAAACGAACTTGTAAAGTAC CTTAAGAGTCTGCATGCGATGGAAGGCCACGTGATGATCGCCTTCTTGCCCACTATCCTAAACCAGCTGTTCCGAGTCCTCACCAGAGCC ACACAGGAAGAAGTCGCGGTTAACGTGACTCGGGTCATTATTCATGTGGTTGCCCAGTGCCATGAGGAAGGATTGGAGAGCCACTTGAGG TCATATGTTAAGTACGCGTATAAGGCTGAGCCATATGTTGCCTCTGAATACAAGACAGTGCATGAAGAACTGACCAAATCCATGACCACG ATTCTCAAGCCTTCTGCCGATTTCCTCACCAGCAACAAACTACTGAAGAAAAGAATTCAAAGAACACTCAGTATGAAAATCTATCCATTC TGGACCAAATCCTTCAAAATATTGGAAGATCTTCAGGAAACATTTTCCATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAG GCAGTCAGTGAGGCCGCAGCCCCAGACCCCCTGCGCAGGAGAGGAGCCTGCTAGAACCCCCACCCACCAGCCTCCGGAACAGGGCACTTG >In-frame_DOCK9_ENST00000448493_chr13_99532801_-_SPACA7_ENST00000375699_chr13_113086758_+_3301nt GACTGCTTGTCACGAAGATGGTACAGTGGGAGCCTGTTTCGGAAGAGCCAAGGAAGAGGATGTGGAAATGGAGTAGAGATTGCTAAAAAA CTGAACATCCACACCTTGGGGATGGGTTGCACTACTAGTGTGATTCTGTTTAAAGGCATCCGCACCGTTTTTGAAAGAAACTGTGCTTAT ATGTGCAAACAGCAAGGAGAGAATAATGCCCTTGAATATACAGCATACAATTGGACAAAAGAAGATTCAGAACTATTGATCTCCTCCTGG CTGGCAAAGCCAAAGCTAATTGAGCCACTCGACTATGAAAATGTCATCGTCCAGAAGAAGACTCAGATCCTGAACGACTGTTTACGGGAG ATGCTGCTCTTCCCTTACGATGACTTTCAGACGGCCATCCTGAGACGACAGGGTCGATACATATGCTCAACAGTGCCTGCGAAGGCGGAA GAGGAAGCACAGAGCTTGTTTGTTACAGAGTGCATCAAAACCTATAACTCTGACTGGCATCTTGTGAACTATAAATATGAAGATTACTCA GGAGAGTTTCGACAGCTTCCGAACAAAGTGGTCAAGTTGGATAAACTTCCAGTTCATGTCTATGAAGTTGACGAGGAGGTCGACAAAGAT GAGGATGCTGCCTCCCTTGGTTCCCAGAAGGGTGGGATCACCAAGCATGGCTGGCTGTACAAAGGCAACATGAACAGTGCCATCAGCGTG ACCATGAGGTCATTTAAGAGACGATTTTTCCACCTGATTCAACTTGGCGATGGATCCTATAATTTGAATTTTTATAAAGATGAAAAGATC TCCAAAGAACCAAAAGGATCAATATTTCTGGATTCCTGTATGGGTGTCGTTCAGAACAACAAAGTCAGGCGTTTTGCTTTTGAGCTCAAG ATGCAGGACAAAAGTAGTTATCTCTTGGCAGCAGACAGTGAAGTGGAAATGGAAGAATGGATCACAATTCTAAATAAGATCCTCCAGCTC AACTTTGAAGCTGCAATGCAAGAAAAGCGAAATGGCGACTCTCACGAAGATGATGAACAAAGCAAATTGGAAGGTTCTGGTTCCGGTTTA GATAGCTACCTGCCGGAACTTGCCAAGAGTGCAAGAGAAGCAGAAATCAAACTGAAAAGTGAAAGCAGAGTCAAACTTTTTTATTTGGAC CCAGATGCCCAGAAGCTTGACTTCTCATCAGCTGAGCCAGAAGTGAAGTCATTTGAAGAGAAGTTTGGAAAAAGGATCCTTGTCAAGTGC AATGATTTATCTTTCAATTTGCAATGCTGTGTTGCCGAAAATGAAGAAGGACCCACTACAAATGTTGAACCTTTCTTTGTTACTCTATCC CTGTTTGACATAAAATACAACCGGAAGATTTCTGCCGATTTCCACGTAGACCTGAACCATTTCTCAGTGAGGCAAATGCTCGCCACCACG TCCCCGGCGCTGATGAATGGCAGTGGGCAGAGCCCATCTGTCCTCAAGGGCATCCTTCATGAAGCCGCCATGCAGTATCCGAAGCAGGGA ATATTTTCAGTCACTTGTCCTCATCCAGATATATTTCTTGTGGCCAGAATTGAAAAAGTCCTTCAGGGGAGCATCACACATTGCGCTGAG CCATATATGAAAAGTTCAGACTCTTCTAAGGTGGCCCAGAAGGTGCTGAAGAATGCCAAGCAGGCATGCCAAAGACTAGGACAGTATAGA ATGCCATTTGCTTGGGCAGCAAGGACATTGTTTAAGGATGCATCTGGAAATCTTGACAAAAATGCCAGATTTTCTGCCATCTACAGGCAA GACAGCAATAAGCTATCCAATGATGACATGCTCAAGTTACTTGCAGACTTTCGGAAACCTGAGAAGATGGCTAAGCTCCCAGTGATTTTA GGCAATCTAGACATTACAATTGATAATGTTTCCTCAGACTTCCCTAATTATGTTAATTCATCATACATTCCCACAAAACAATTTGAAACC TGCAGTAAAACTCCCATCACGTTTGAAGTGGAGGAATTTGTGCCCTGCATACCAAAACACACTCAGCCTTACACCATCTACACCAATCAC CTTTACGTTTATCCTAAGTACTTGAAATACGACAGTCAGAAGTCTTTTGCCAAGGCTAGAAATATTGCGATTTGCATTGAATTCAAAGAT TCAGATGAGGAAGACTCTCAGCCCCTTAAGTGCATTTATGGCAGACCTGGTGGGCCAGTTTTCACAAGAAGCGCCTTTGCTGCAGTTTTA CACCATCACCAAAACCCAGAATTTTATGATGAGATTAAAATAGAGTTGCCCACTCAGCTGCATGAAAAGCACCACCTGTTGCTCACATTC TTCCATGTCAGCTGTGACAACTCAAGTAAAGGAAGCACGAAGAAGAGGGATGTCGTTGAAACCCAAGTTGGCTACTCCTGGCTTCCCCTC CTGAAAGACGGAAGGGTGGTGACAAGCGAGCAGCACATCCCGGTCTCGGCGAACCTTCCTTCGGGCTATCTTGGCTACCAGGAGCTTGGG ATGGGCAGGCATTATGGTCCGGAAATTAAATGGGTAGATGGAGGCAAGCCACTGCTGAAAATTTCCACTCATCTGGTTTCTACAGTGTAT ACTCAGGATCAGCATTTACATAATTTTTTCCAGTACTGTCAGAAAACCGAATCTGGAGCCCAAGCCTTAGGAAACGAACTTGTAAAGTAC CTTAAGAGTCTGCATGCGATGGAAGGCCACGTGATGATCGCCTTCTTGCCCACTATCCTAAACCAGCTGTTCCGAGTCCTCACCAGAGCC ACACAGGAAGAAGTCGCGGTTAACGTGACTCGGGTCATTATTCATGTGGTTGCCCAGTGCCATGAGGAAGGATTGGAGAGCCACTTGAGG TCATATGTTAAGTACGCGTATAAGGCTGAGCCATATGTTGCCTCTGAATACAAGACAGTGCATGAAGAACTGACCAAATCCATGACCACG ATTCTCAAGCCTTCTGCCGATTTCCTCACCAGCAACAAACTACTGAAGAAAAGAATTCAAAGAACACTCAGTATGAAAATCTATCCATTC TGGACCAAATCCTTCAAAATATTGGAAGATCTTCAGGAAACATTTTCCATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAG GCAGTCAGTGAGGCCGCAGCCCCAGACCCCCTGCGCAGGAGAGGAGCCTGCTAGAACCCCCACCCACCAGCCTCCGGAACAGGGCACTTG |
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FusionGenePPI for DOCK9_SPACA7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DOCK9 | CDC42, CUL4B, LNX1, SMAD2, SMAD3, CDH1, DOCK10, C10orf88 | SPACA7 | HSPB1, KRAS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DOCK9_SPACA7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOCK9_SPACA7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DOCK9 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
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