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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10415

FusionGeneSummary for DOCK7_NMT2

check button Fusion gene summary
Fusion gene informationFusion gene name: DOCK7_NMT2
Fusion gene ID: 10415
HgeneTgene
Gene symbol

DOCK7

NMT2

Gene ID

85440

9397

Gene namededicator of cytokinesis 7N-myristoyltransferase 2
SynonymsEIEE23|ZIR2-
Cytomap

1p31.3

10p13

Type of geneprotein-codingprotein-coding
Descriptiondedicator of cytokinesis protein 7glycylpeptide N-tetradecanoyltransferase 2NMT 2glycylpeptide N-tetradecanoyltransferase 2 variant 3glycylpeptide N-tetradecanoyltransferase 2 variant 4myristoyl-CoA:protein N-myristoyltransferase 2peptide N-myristoyltransferase 2type II N-myristoylt
Modification date2018052320180523
UniProtAcc

Q96N67

O60551

Ensembl transtripts involved in fusion geneENST00000251157, ENST00000340370, 
ENST00000489185, ENST00000404627, 
ENST00000378165, ENST00000378150, 
ENST00000535341, ENST00000466201, 
ENST00000540259, 
Fusion gene scores* DoF score7 X 4 X 5=1403 X 3 X 3=27
# samples 63
** MAII scorelog2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DOCK7 [Title/Abstract] AND NMT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDOCK7

GO:0090630

activation of GTPase activity

16982419

TgeneNMT2

GO:0018008

N-terminal peptidyl-glycine N-myristoylation

25255805


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-IF-A4AK-01ADOCK7chr1

63153898

-NMT2chr10

15183556

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000251157ENST00000378165DOCK7chr1

63153898

-NMT2chr10

15183556

-
Frame-shitENST00000251157ENST00000378150DOCK7chr1

63153898

-NMT2chr10

15183556

-
Frame-shitENST00000251157ENST00000535341DOCK7chr1

63153898

-NMT2chr10

15183556

-
5CDS-intronENST00000251157ENST00000466201DOCK7chr1

63153898

-NMT2chr10

15183556

-
5CDS-5UTRENST00000251157ENST00000540259DOCK7chr1

63153898

-NMT2chr10

15183556

-
Frame-shitENST00000340370ENST00000378165DOCK7chr1

63153898

-NMT2chr10

15183556

-
Frame-shitENST00000340370ENST00000378150DOCK7chr1

63153898

-NMT2chr10

15183556

-
Frame-shitENST00000340370ENST00000535341DOCK7chr1

63153898

-NMT2chr10

15183556

-
5CDS-intronENST00000340370ENST00000466201DOCK7chr1

63153898

-NMT2chr10

15183556

-
5CDS-5UTRENST00000340370ENST00000540259DOCK7chr1

63153898

-NMT2chr10

15183556

-
intron-3CDSENST00000489185ENST00000378165DOCK7chr1

63153898

-NMT2chr10

15183556

-
intron-3CDSENST00000489185ENST00000378150DOCK7chr1

63153898

-NMT2chr10

15183556

-
intron-3CDSENST00000489185ENST00000535341DOCK7chr1

63153898

-NMT2chr10

15183556

-
intron-intronENST00000489185ENST00000466201DOCK7chr1

63153898

-NMT2chr10

15183556

-
intron-5UTRENST00000489185ENST00000540259DOCK7chr1

63153898

-NMT2chr10

15183556

-
Frame-shitENST00000404627ENST00000378165DOCK7chr1

63153898

-NMT2chr10

15183556

-
Frame-shitENST00000404627ENST00000378150DOCK7chr1

63153898

-NMT2chr10

15183556

-
Frame-shitENST00000404627ENST00000535341DOCK7chr1

63153898

-NMT2chr10

15183556

-
5CDS-intronENST00000404627ENST00000466201DOCK7chr1

63153898

-NMT2chr10

15183556

-
5CDS-5UTRENST00000404627ENST00000540259DOCK7chr1

63153898

-NMT2chr10

15183556

-

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FusionProtFeatures for DOCK7_NMT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DOCK7

Q96N67

NMT2

O60551

Adds a myristoyl group to the N-terminal glycine residueof certain cellular and viral proteins.{ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9506952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DOCK7_NMT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DOCK7_NMT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DOCK7TSC1, USP19, USP7, GTF2A1, MLH1, YWHAG, MARK4, YWHAH, YWHAZ, PPP2CB, GRB7, BCL2L1, SNCA, RPP14, TK1, CDKN1A, SMN1, ANXA7, SOX2, SIRT7, VCP, PAN2, CRLF3, DOCK6, LRCH1, LRCH2, LRCH3, DOCK8, LRCH4, MOB1A, MOB1B, WHSC1L1, WWOX, LGR4, STAU1, AURKB, CEP250, TP53, TUBGCP3, MOV10, NXF1, CCDC8, PIH1D1, ARPC3, PPP1R18, SKAP1, LPCAT1, PTGER3, RASSF10, FBXW11, NTRK1, IFI16, PLK4, MED23, XPO1, CAPZA2, CDK2, MYH9, MYO1C, MYO19, MYO6, DUSP13, DUSP26, MTMR7, AVIL, TMOD3, ZNF785, TGM5, PRPSAP2, IRF3, LGALS7, KLHDC9, CBY1, DCAF7, UBE2ANMT2ANXA4, CSNK2B, PRKCZ, TK1, SMN1, ANXA7, APP, PPP1CC, TMED9, TP53, BCL2, FBXO17, ODF3L2, FAM84B, PRPS2, PRPS1, TGFB1, GFOD1, ZNRF1, GPRC5C, ASB6, NCS1, MARCKSL1, ANGPTL4, AIFM3, TLDC1, MGST3, DEFB1, FAM109B, FAM45A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DOCK7_NMT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DOCK7_NMT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDOCK7C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNMT2C0029927Ovarian Cysts1CTD_human