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Fusion gene ID: 1041 |
FusionGeneSummary for AFTPH_KIAA1841 |
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Fusion gene information | Fusion gene name: AFTPH_KIAA1841 | Fusion gene ID: 1041 | Hgene | Tgene | Gene symbol | AFTPH | KIAA1841 | Gene ID | 54812 | 84542 |
Gene name | aftiphilin | KIAA1841 | |
Synonyms | Nbla10388 | - | |
Cytomap | 2p14 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | aftiphilinaftiphilin protein | uncharacterized protein KIAA1841 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q6ULP2 | Q6NSI8 | |
Ensembl transtripts involved in fusion gene | ENST00000238855, ENST00000422803, ENST00000238856, ENST00000409933, ENST00000409183, ENST00000487769, | ENST00000402291, ENST00000356719, ENST00000295031, ENST00000453873, ENST00000482513, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 7 X 5 X 5=175 |
# samples | 7 | 8 | |
** MAII score | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AFTPH [Title/Abstract] AND KIAA1841 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-DU-A7TJ-01A | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000238855 | ENST00000402291 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000238855 | ENST00000356719 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000238855 | ENST00000295031 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000238855 | ENST00000453873 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-intron | ENST00000238855 | ENST00000482513 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000422803 | ENST00000402291 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000422803 | ENST00000356719 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000422803 | ENST00000295031 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000422803 | ENST00000453873 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-intron | ENST00000422803 | ENST00000482513 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000238856 | ENST00000402291 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000238856 | ENST00000356719 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000238856 | ENST00000295031 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-3CDS | ENST00000238856 | ENST00000453873 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
5UTR-intron | ENST00000238856 | ENST00000482513 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000409933 | ENST00000402291 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000409933 | ENST00000356719 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000409933 | ENST00000295031 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000409933 | ENST00000453873 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-intron | ENST00000409933 | ENST00000482513 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000409183 | ENST00000402291 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000409183 | ENST00000356719 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000409183 | ENST00000295031 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000409183 | ENST00000453873 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-intron | ENST00000409183 | ENST00000482513 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000487769 | ENST00000402291 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000487769 | ENST00000356719 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000487769 | ENST00000295031 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-3CDS | ENST00000487769 | ENST00000453873 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
intron-intron | ENST00000487769 | ENST00000482513 | AFTPH | chr2 | 64751746 | + | KIAA1841 | chr2 | 61343114 | + |
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FusionProtFeatures for AFTPH_KIAA1841 |
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Hgene | Tgene |
AFTPH | KIAA1841 |
May play a role in membrane trafficking. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AFTPH_KIAA1841 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AFTPH_KIAA1841 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AFTPH | UBE3A, LIG4, STAT5B, VAPB, NTRK1, XPO1, AP1S2, VAPA, AP1M2 | KIAA1841 | APP, SRPK1, NICN1, LRRC49, TTLL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AFTPH_KIAA1841 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AFTPH_KIAA1841 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |