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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1041

FusionGeneSummary for AFTPH_KIAA1841

check button Fusion gene summary
Fusion gene informationFusion gene name: AFTPH_KIAA1841
Fusion gene ID: 1041
HgeneTgene
Gene symbol

AFTPH

KIAA1841

Gene ID

54812

84542

Gene nameaftiphilinKIAA1841
SynonymsNbla10388-
Cytomap

2p14

2p15

Type of geneprotein-codingprotein-coding
Descriptionaftiphilinaftiphilin proteinuncharacterized protein KIAA1841
Modification date2018052320180519
UniProtAcc

Q6ULP2

Q6NSI8

Ensembl transtripts involved in fusion geneENST00000238855, ENST00000422803, 
ENST00000238856, ENST00000409933, 
ENST00000409183, ENST00000487769, 
ENST00000402291, ENST00000356719, 
ENST00000295031, ENST00000453873, 
ENST00000482513, 
Fusion gene scores* DoF score6 X 5 X 5=1507 X 5 X 5=175
# samples 78
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AFTPH [Title/Abstract] AND KIAA1841 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-A7TJ-01AAFTPHchr2

64751746

+KIAA1841chr2

61343114

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000238855ENST00000402291AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000238855ENST00000356719AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000238855ENST00000295031AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000238855ENST00000453873AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-intronENST00000238855ENST00000482513AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000422803ENST00000402291AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000422803ENST00000356719AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000422803ENST00000295031AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000422803ENST00000453873AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-intronENST00000422803ENST00000482513AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000238856ENST00000402291AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000238856ENST00000356719AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000238856ENST00000295031AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-3CDSENST00000238856ENST00000453873AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
5UTR-intronENST00000238856ENST00000482513AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000409933ENST00000402291AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000409933ENST00000356719AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000409933ENST00000295031AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000409933ENST00000453873AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-intronENST00000409933ENST00000482513AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000409183ENST00000402291AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000409183ENST00000356719AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000409183ENST00000295031AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000409183ENST00000453873AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-intronENST00000409183ENST00000482513AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000487769ENST00000402291AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000487769ENST00000356719AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000487769ENST00000295031AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-3CDSENST00000487769ENST00000453873AFTPHchr2

64751746

+KIAA1841chr2

61343114

+
intron-intronENST00000487769ENST00000482513AFTPHchr2

64751746

+KIAA1841chr2

61343114

+

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FusionProtFeatures for AFTPH_KIAA1841


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFTPH

Q6ULP2

KIAA1841

Q6NSI8

May play a role in membrane trafficking.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AFTPH_KIAA1841


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AFTPH_KIAA1841


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AFTPHUBE3A, LIG4, STAT5B, VAPB, NTRK1, XPO1, AP1S2, VAPA, AP1M2KIAA1841APP, SRPK1, NICN1, LRRC49, TTLL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AFTPH_KIAA1841


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AFTPH_KIAA1841


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource