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Fusion gene ID: 10401 |
FusionGeneSummary for DOCK4_NRCAM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK4_NRCAM | Fusion gene ID: 10401 | Hgene | Tgene | Gene symbol | DOCK4 | NRCAM | Gene ID | 9732 | 4897 |
| Gene name | dedicator of cytokinesis 4 | neuronal cell adhesion molecule | |
| Synonyms | - | - | |
| Cytomap | 7q31.1 | 7q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 4 | neuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravo | |
| Modification date | 20180525 | 20180519 | |
| UniProtAcc | Q8N1I0 | Q92823 | |
| Ensembl transtripts involved in fusion gene | ENST00000428084, ENST00000494651, ENST00000437633, ENST00000476846, | ENST00000379028, ENST00000413765, ENST00000351718, ENST00000379024, ENST00000379022, ENST00000425651, ENST00000522550, | |
| Fusion gene scores | * DoF score | 6 X 2 X 5=60 | 3 X 3 X 3=27 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/60*10)=0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DOCK4 [Title/Abstract] AND NRCAM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NRCAM | GO:0045162 | clustering of voltage-gated sodium channels | 14602817 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-5P-A9JZ-01A | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000428084 | ENST00000379028 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000428084 | ENST00000413765 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000428084 | ENST00000351718 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000428084 | ENST00000379024 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000428084 | ENST00000379022 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-intron | ENST00000428084 | ENST00000425651 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-intron | ENST00000428084 | ENST00000522550 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000379028 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000413765 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000351718 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000379024 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000379022 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-intron | ENST00000494651 | ENST00000425651 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-intron | ENST00000494651 | ENST00000522550 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000379028 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000413765 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000351718 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000379024 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000379022 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-intron | ENST00000437633 | ENST00000425651 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-intron | ENST00000437633 | ENST00000522550 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000379028 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000413765 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000351718 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000379024 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000379022 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-intron | ENST00000476846 | ENST00000425651 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-intron | ENST00000476846 | ENST00000522550 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
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FusionProtFeatures for DOCK4_NRCAM |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK4 | NRCAM |
| Involved in regulation of adherens junction betweencells. Plays a role in cell migration. Functions as a guaninenucleotide exchange factor (GEF), which activates Rap1 smallGTPase by exchanging bound GDP for free GTP.{ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:20679435}. | Cell adhesion protein that is required for normalresponses to cell-cell contacts in brain and in the peripheralnervous system. Plays a role in neurite outgrowth in response tocontactin binding. Plays a role in mediating cell-cell contactsbetween Schwann cells and axons. Plays a role in the formation andmaintenance of the nodes of Ranvier on myelinated axons. Nodes ofRanvier contain clustered sodium channels that are crucial for thesaltatory propagation of action potentials along myelinated axons.During development, nodes of Ranvier are formed by the fusion oftwo heminodes. Required for normal clustering of sodium channelsat heminodes; not required for the formation of mature nodes withnormal sodium channel clusters. Required, together with GLDN, formaintaining NFASC and sodium channel clusters at mature nodes ofRanvier. {ECO:0000250|UniProtKB:Q810U4}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DOCK4_NRCAM |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DOCK4_NRCAM |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DOCK4 | HNRNPL, YWHAB, RNF115, FASLG, GRK5, EGFR, EIF4A3, MAGOH, GRB2, NPM1, ELMO1, NTRK1, ELMO3, ARRB1, ERMAP, STAT1, VSIG8 | NRCAM | PTPRB, CNTN2, HSPA12A, MACF1, MAGI3, LNX1, FRMD5, NTRK1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DOCK4_NRCAM |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOCK4_NRCAM |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DOCK4 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | DOCK4 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | NRCAM | C0004352 | Autistic Disorder | 2 | CTD_human |
| Tgene | NRCAM | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Tgene | NRCAM | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | NRCAM | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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