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Fusion gene ID: 10386 |
FusionGeneSummary for DOCK1_PPAPDC1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK1_PPAPDC1A | Fusion gene ID: 10386 | Hgene | Tgene | Gene symbol | DOCK1 | PPAPDC1A | Gene ID | 1793 | 196051 |
| Gene name | dedicator of cytokinesis 1 | phospholipid phosphatase 4 | |
| Synonyms | DOCK180|ced5 | DPPL2|PPAPDC1|PPAPDC1A | |
| Cytomap | 10q26.2 | 10q26.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK | phospholipid phosphatase 4diacylglycerol pyrophosphate like 2diacylglycerol pyrophosphate phosphatase-like 2phosphatidate phosphatase PPAPDC1Aphosphatidic acid phosphatase type 2 domain containing 1Aphosphatidic acid phosphatase type 2 domain-contain | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q14185 | ||
| Ensembl transtripts involved in fusion gene | ENST00000280333, ENST00000484400, | ENST00000398250, ENST00000439221, ENST00000398248, ENST00000541332, ENST00000369073, ENST00000496437, | |
| Fusion gene scores | * DoF score | 12 X 12 X 8=1152 | 6 X 3 X 6=108 |
| # samples | 13 | 8 | |
| ** MAII score | log2(13/1152*10)=-3.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DOCK1 [Title/Abstract] AND PPAPDC1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PPAPDC1A | GO:0046839 | phospholipid dephosphorylation | 17590538 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A04U-01A | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000280333 | ENST00000398250 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| In-frame | ENST00000280333 | ENST00000439221 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| In-frame | ENST00000280333 | ENST00000398248 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| In-frame | ENST00000280333 | ENST00000541332 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| In-frame | ENST00000280333 | ENST00000369073 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| 5CDS-intron | ENST00000280333 | ENST00000496437 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000398250 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000439221 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000398248 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000541332 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000369073 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-intron | ENST00000484400 | ENST00000496437 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
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FusionProtFeatures for DOCK1_PPAPDC1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK1 | PPAPDC1A |
| Involved in cytoskeletal rearrangements required forphagocytosis of apoptotic cells and cell motility. Along withDOCK1, mediates CRK/CRKL regulation of epithelial and endothelialcell spreading and migration on type IV collagen(PubMed:19004829). Functions as a guanine nucleotide exchangefactor (GEF), which activates Rac Rho small GTPases by exchangingbound GDP for free GTP. Its GEF activity may be enhanced by ELMO1(PubMed:8657152). {ECO:0000269|PubMed:19004829,ECO:0000269|PubMed:8657152}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DOCK1 | chr10:128796513 | chr10:122263330 | ENST00000280333 | + | 8 | 52 | 9_70 | 255 | 1866 | Domain | SH3 |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 102_110 | 18 | 97 | Region | Note=Phosphatase sequence motif I |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 143_146 | 18 | 97 | Region | Note=Phosphatase sequence motif II |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 195_205 | 18 | 97 | Region | Note=Phosphatase sequence motif III |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 102_110 | 18 | 272 | Region | Note=Phosphatase sequence motif I |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 143_146 | 18 | 272 | Region | Note=Phosphatase sequence motif II |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 195_205 | 18 | 272 | Region | Note=Phosphatase sequence motif III |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 102_110 | 18 | 209 | Region | Note=Phosphatase sequence motif I |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 143_146 | 18 | 209 | Region | Note=Phosphatase sequence motif II |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 195_205 | 18 | 209 | Region | Note=Phosphatase sequence motif III |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 142_162 | 18 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 179_199 | 18 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 202_222 | 18 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 49_69 | 18 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 84_104 | 18 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 142_162 | 18 | 272 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 179_199 | 18 | 272 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 202_222 | 18 | 272 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 49_69 | 18 | 272 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 84_104 | 18 | 272 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 142_162 | 18 | 209 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 179_199 | 18 | 209 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 202_222 | 18 | 209 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 49_69 | 18 | 209 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 84_104 | 18 | 209 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DOCK1 | chr10:128796513 | chr10:122263330 | ENST00000280333 | + | 8 | 52 | 1207_1617 | 255 | 1866 | Domain | DHR-2 |
| Hgene | >DOCK1 | chr10:128796513 | chr10:122263330 | ENST00000280333 | + | 8 | 52 | 425_609 | 255 | 1866 | Domain | DHR-1 |
| Hgene | >DOCK1 | chr10:128796513 | chr10:122263330 | ENST00000280333 | + | 8 | 52 | 1687_1695 | 255 | 1866 | Region | Phosphoinositide-binding |
| Tgene | PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398248 | + | 0 | 3 | 4_24 | 18 | 97 | Transmembrane | Helical |
| Tgene | PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000398250 | + | 0 | 7 | 4_24 | 18 | 272 | Transmembrane | Helical |
| Tgene | PPAPDC1A | chr10:128796513 | chr10:122263330 | ENST00000439221 | + | 0 | 5 | 4_24 | 18 | 209 | Transmembrane | Helical |
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FusionGeneSequence for DOCK1_PPAPDC1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000398250_chr10_122263330_+_509aa MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQ EVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTS TISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISFTEFLDPFQRVIQP EEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGVMN SEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVI >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000439221_chr10_122263330_+_446aa MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQ EVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTS TISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISFTEFLDPFQRVIQP EEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLVAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPL >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000398248_chr10_122263330_+_334aa MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQ EVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTS TISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISFTEFLDPFQRVIQP >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000541332_chr10_122263330_+_471aa MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQ EVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTS TISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISFTEFLDPFQRVIQP EEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGVMN SEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQVGCCVWQG >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000369073_chr10_122263330_+_509aa MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQ EVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTS TISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISFTEFLDPFQRVIQP EEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGVMN SEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000398250_chr10_122263330_+_1527nt ATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGGAGCGGATGAACTTTCTTTA CAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAAGTCTAAGAAGGGTATATTT CCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGGTGACCTCCCCCTCATCCAG GAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGATGTTTCGAAGTGTGCGGCAC ATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGAACTGAAGAAGAAGGTCACA GCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTTGGATCCAGAATTAACTAGC ACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATCTCAAAAGCAGAACATAGAT ATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTGTAAAATAGGAGAAGATGCT GAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTTCCAGAGAGTCATCCAGCCA GAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTGCAATTTCTTTCCTCACACCCCTG GCTGTTATTTGTGTGGTGAAAATTATCCGGCGAACAGACAAGACTGAAATTAAGGAAGCCTTCTTAGCGGTGTCCTTGGCTCTTGCTTTG AATGGAGTCTGCACAAACACTATTAAATTAATAGTGGGAAGACCTCGCCCCGATTTCTTTTACCGCTGCTTTCCAGATGGAGTGATGAAC TCGGAAATGCATTGCACAGGTGACCCCGATCTGGTGTCCGAGGGCCGCAAAAGCTTCCCCAGCATCCATTCCTCCTTTGCCTTTTCGGGC CTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTCTGTGCTGCCATC CTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTCCTTTGTGGGTGGAGTCATC GGCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTTAGTCTGCGAGTC >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000439221_chr10_122263330_+_1338nt ATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGGAGCGGATGAACTTTCTTTA CAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAAGTCTAAGAAGGGTATATTT CCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGGTGACCTCCCCCTCATCCAG GAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGATGTTTCGAAGTGTGCGGCAC ATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGAACTGAAGAAGAAGGTCACA GCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTTGGATCCAGAATTAACTAGC ACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATCTCAAAAGCAGAACATAGAT ATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTGTAAAATAGGAGAAGATGCT GAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTTCCAGAGAGTCATCCAGCCA GAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTGCAATTTCTTTCCTCACACCCCTG GCTGTTATTTGTGTGGTGAAAATTATCCGGCGAACAGACAAGACTGAAATTAAGGAAGCCTTCTTAGTTGCCTTTTCGGGCCTTGGCTTC ACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTCTGTGCTGCCATCCTGCCCTTG TACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTCCTTTGTGGGTGGAGTCATCGGCCTCATT TTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTTAGTCTGCGAGTCCCAGCCTCA >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000398248_chr10_122263330_+_1002nt ATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGGAGCGGATGAACTTTCTTTA CAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAAGTCTAAGAAGGGTATATTT CCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGGTGACCTCCCCCTCATCCAG GAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGATGTTTCGAAGTGTGCGGCAC ATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGAACTGAAGAAGAAGGTCACA GCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTTGGATCCAGAATTAACTAGC ACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATCTCAAAAGCAGAACATAGAT ATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTGTAAAATAGGAGAAGATGCT GAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTTCCAGAGAGTCATCCAGCCA GAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTATTCCTTTGTGGGTGGAGTCATCG GCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTTAGTCTGCGAGTCC >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000541332_chr10_122263330_+_1413nt ATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGGAGCGGATGAACTTTCTTTA CAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAAGTCTAAGAAGGGTATATTT CCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGGTGACCTCCCCCTCATCCAG GAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGATGTTTCGAAGTGTGCGGCAC ATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGAACTGAAGAAGAAGGTCACA GCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTTGGATCCAGAATTAACTAGC ACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATCTCAAAAGCAGAACATAGAT ATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTGTAAAATAGGAGAAGATGCT GAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTTCCAGAGAGTCATCCAGCCA GAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTGCAATTTCTTTCCTCACACCCCTG GCTGTTATTTGTGTGGTGAAAATTATCCGGCGAACAGACAAGACTGAAATTAAGGAAGCCTTCTTAGCGGTGTCCTTGGCTCTTGCTTTG AATGGAGTCTGCACAAACACTATTAAATTAATAGTGGGAAGACCTCGCCCCGATTTCTTTTACCGCTGCTTTCCAGATGGAGTGATGAAC TCGGAAATGCATTGCACAGGTGACCCCGATCTGGTGTCCGAGGGCCGCAAAAGCTTCCCCAGCATCCATTCCTCCTTTGCCTTTTCGGGC CTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTCTGTGCTGCCATC CTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGTTGGCTGCTGTGTATGGCAGGGC >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000369073_chr10_122263330_+_1527nt ATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGGAGCGGATGAACTTTCTTTA CAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAAGTCTAAGAAGGGTATATTT CCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGGTGACCTCCCCCTCATCCAG GAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGATGTTTCGAAGTGTGCGGCAC ATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGAACTGAAGAAGAAGGTCACA GCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTTGGATCCAGAATTAACTAGC ACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATCTCAAAAGCAGAACATAGAT ATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTGTAAAATAGGAGAAGATGCT GAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTTCCAGAGAGTCATCCAGCCA GAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTGCAATTTCTTTCCTCACACCCCTG GCTGTTATTTGTGTGGTGAAAATTATCCGGCGAACAGACAAGACTGAAATTAAGGAAGCCTTCTTAGCGGTGTCCTTGGCTCTTGCTTTG AATGGAGTCTGCACAAACACTATTAAATTAATAGTGGGAAGACCTCGCCCCGATTTCTTTTACCGCTGCTTTCCAGATGGAGTGATGAAC TCGGAAATGCATTGCACAGGTGACCCCGATCTGGTGTCCGAGGGCCGCAAAAGCTTCCCCAGCATCCATTCCTCCTTTGCCTTTTCGGGC CTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTCTGTGCTGCCATC CTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTCCTTTGTGGGTGGAGTCATC GGCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTTAGTCTGCGAGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000398250_chr10_122263330_+_1989nt CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTT CCAGAGAGTCATCCAGCCAGAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTGCAAT TTCTTTCCTCACACCCCTGGCTGTTATTTGTGTGGTGAAAATTATCCGGCGAACAGACAAGACTGAAATTAAGGAAGCCTTCTTAGCGGT GTCCTTGGCTCTTGCTTTGAATGGAGTCTGCACAAACACTATTAAATTAATAGTGGGAAGACCTCGCCCCGATTTCTTTTACCGCTGCTT TCCAGATGGAGTGATGAACTCGGAAATGCATTGCACAGGTGACCCCGATCTGGTGTCCGAGGGCCGCAAAAGCTTCCCCAGCATCCATTC CTCCTTTGCCTTTTCGGGCCTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTG GCGGCTCTGTGCTGCCATCCTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTC CTTTGTGGGTGGAGTCATCGGCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACC CTACGTTAGTCTGCGAGTCCCAGCCTCACTGAAGAAAGAGGAGAGGCCCACAGCTGACAGCGCACCCAGCTTGCCTCTGGAGGGGATCAC CGAAGGCCCGGTATGACCAGTGTCCTGGGAGGATGGACACTAAGCCCTGGGCACATCTGCCACCCTGACATCATAACACAATAGAAATGG TTTTCTGTAGTGTATTTTTCATCAGTTGTTTCTCAAAGTCATCGTACTTCTGCTTCTGTTTCACTGATGGTGTTCCTGCTACTTTAAATG TCTACTTCCAACATCCTTGAATTTGCAAGTGAAGGACAACAATCTCTGAGAGACGTGTGGAAGAGGCTGTGAAGGTGGGGTTTGGGGAGC TTGGCCGATTCGTCTATCTGAAATGTTTGCTGTAACAGCCACCTTCCTATGTTTTCATGGTTGTAAAACATAATAAAACCTCCCACGTGG >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000439221_chr10_122263330_+_1800nt CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTT CCAGAGAGTCATCCAGCCAGAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTGCAAT TTCTTTCCTCACACCCCTGGCTGTTATTTGTGTGGTGAAAATTATCCGGCGAACAGACAAGACTGAAATTAAGGAAGCCTTCTTAGTTGC CTTTTCGGGCCTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTCTG TGCTGCCATCCTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTCCTTTGTGGG TGGAGTCATCGGCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTTAG TCTGCGAGTCCCAGCCTCACTGAAGAAAGAGGAGAGGCCCACAGCTGACAGCGCACCCAGCTTGCCTCTGGAGGGGATCACCGAAGGCCC GGTATGACCAGTGTCCTGGGAGGATGGACACTAAGCCCTGGGCACATCTGCCACCCTGACATCATAACACAATAGAAATGGTTTTCTGTA GTGTATTTTTCATCAGTTGTTTCTCAAAGTCATCGTACTTCTGCTTCTGTTTCACTGATGGTGTTCCTGCTACTTTAAATGTCTACTTCC AACATCCTTGAATTTGCAAGTGAAGGACAACAATCTCTGAGAGACGTGTGGAAGAGGCTGTGAAGGTGGGGTTTGGGGAGCTTGGCCGAT TCGTCTATCTGAAATGTTTGCTGTAACAGCCACCTTCCTATGTTTTCATGGTTGTAAAACATAATAAAACCTCCCACGTGGAAGACTTGG >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000398248_chr10_122263330_+_1538nt CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTT CCAGAGAGTCATCCAGCCAGAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTATTCC TTTGTGGGTGGAGTCATCGGCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCC TACGTTAGTCTGCGAGTCCCAGCCTCACTGAAGAAAGAGGAGAGGCCCACAGCTGACAGCGCACCCAGCTTGCCTCTGGAGGGGATCACC GAAGGCCCGGTATGACCAGTGTCCTGGGAGGATGGACACTAAGCCCTGGGCACATCTGCCACCCTGACATCATAACACAATAGAAATGGT TTTCTGTAGTGTATTTTTCATCAGTTGTTTCTCAAAGTCATCGTACTTCTGCTTCTGTTTCACTGATGGTGTTCCTGCTACTTTAAATGT CTACTTCCAACATCCTTGAATTTGCAAGTGAAGGACAACAATCTCTGAGAGACGTGTGGAAGAGGCTGTGAAGGTGGGGTTTGGGGAGCT TGGCCGATTCGTCTATCTGAAATGTTTGCTGTAACAGCCACCTTCCTATGTTTTCATGGTTGTAAAACATAATAAAACCTCCCACGTGGA >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000541332_chr10_122263330_+_2185nt CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTT CCAGAGAGTCATCCAGCCAGAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTGCAAT TTCTTTCCTCACACCCCTGGCTGTTATTTGTGTGGTGAAAATTATCCGGCGAACAGACAAGACTGAAATTAAGGAAGCCTTCTTAGCGGT GTCCTTGGCTCTTGCTTTGAATGGAGTCTGCACAAACACTATTAAATTAATAGTGGGAAGACCTCGCCCCGATTTCTTTTACCGCTGCTT TCCAGATGGAGTGATGAACTCGGAAATGCATTGCACAGGTGACCCCGATCTGGTGTCCGAGGGCCGCAAAAGCTTCCCCAGCATCCATTC CTCCTTTGCCTTTTCGGGCCTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTG GCGGCTCTGTGCTGCCATCCTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGTTGG CTGCTGTGTATGGCAGGGCCCACAGTCACATTTACCATCGGCTGCCAACCCCCGCCTCTGTCTGGGAACCTCTGAACCTTGACTGCCCAT CTAAGTCCACCCGCCTCTGTGTTGGTGCCTAGGAGAGCGTAAGAAGCCTCAGCCCCTGGCTCACCCCTCCCTCCGGTCAAAGTCCACTGC ATATCCTGCTTTCAGCCTCAAGAGAGGCATTCTCAGTCAGGACTTCTGCCCTCTTCCTGCCTCCAGGATAGCCCTGGTGTTTCCCCGTGA TGTAATTCCCAGGGAAGATGGACGTTGATTGCTCCCAAGTCTCACTGGCATCCTTCCTTTGTTTTACTCAAGGGAACCTGTCTCTTCTCA GCTTTCTGTGGTGTTCTGTGGTTCCTCCTGCTCAGCATATTTATAGACTCCAACTTTTCCTTCCCACTCTGGTCTAGTGATCCTCAGTTG TTGCCTGAATCATTGCAGAAGCCTCTCAGCCTGGCTCCCTCCTTCCTTCTTTGGCCCTCAACTGCATTTGGAATGTGCCTTTAGAGCCTG CGTTAGCACATGTCACTTTTGCAAAAATCCTCCAGTGATTCTCATTTCACTCAGCATCACAGCCTGTGTCCTGCCATGGTCCATAAGATC TGCTCCCTCCGTACTTCTTTGATGCTATGTTCAAGCTACTTGTCCTCCTCGTTCACATGATTGCATCGCTTGAGCTTCTTGCTACTCCTT >In-frame_DOCK1_ENST00000280333_chr10_128796513_+_PPAPDC1A_ENST00000369073_chr10_122263330_+_1985nt CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTTTTACAGAGTTTTTGGATCCGTT CCAGAGAGTCATCCAGCCAGAAGAGATCTGGCTCTATAAAAATCCTTTGGTGCAATCAGATAACATACCTACCCGCCTCATGTTTGCAAT TTCTTTCCTCACACCCCTGGCTGTTATTTGTGTGGTGAAAATTATCCGGCGAACAGACAAGACTGAAATTAAGGAAGCCTTCTTAGCGGT GTCCTTGGCTCTTGCTTTGAATGGAGTCTGCACAAACACTATTAAATTAATAGTGGGAAGACCTCGCCCCGATTTCTTTTACCGCTGCTT TCCAGATGGAGTGATGAACTCGGAAATGCATTGCACAGGTGACCCCGATCTGGTGTCCGAGGGCCGCAAAAGCTTCCCCAGCATCCATTC CTCCTTTGCCTTTTCGGGCCTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTG GCGGCTCTGTGCTGCCATCCTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTC CTTTGTGGGTGGAGTCATCGGCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACC CTACGTTAGTCTGCGAGTCCCAGCCTCACTGAAGAAAGAGGAGAGGCCCACAGCTGACAGCGCACCCAGCTTGCCTCTGGAGGGGATCAC CGAAGGCCCGGTATGACCAGTGTCCTGGGAGGATGGACACTAAGCCCTGGGCACATCTGCCACCCTGACATCATAACACAATAGAAATGG TTTTCTGTAGTGTATTTTTCATCAGTTGTTTCTCAAAGTCATCGTACTTCTGCTTCTGTTTCACTGATGGTGTTCCTGCTACTTTAAATG TCTACTTCCAACATCCTTGAATTTGCAAGTGAAGGACAACAATCTCTGAGAGACGTGTGGAAGAGGCTGTGAAGGTGGGGTTTGGGGAGC TTGGCCGATTCGTCTATCTGAAATGTTTGCTGTAACAGCCACCTTCCTATGTTTTCATGGTTGTAAAACATAATAAAACCTCCCACGTGG |
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FusionGenePPI for DOCK1_PPAPDC1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DOCK1 | RHOG, BCAR1, CRK, GRB2, SRC, PTK2, ELMO1, RAC1, NCK2, MEPCE, MAP1LC3B, CUL1, FBXW11, BTRC, NTRK1, CRKL, SNW1, ARL4A, ELMO3, RAC2, PRKACA | PPAPDC1A | PPAPDC1A, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | DOCK1 | chr10:128796513 | chr10:122263330 | ENST00000280333 | + | 8 | 52 | 1837_1852 | 255 | 1866 | NCK2 (minor) |
| Hgene | DOCK1 | chr10:128796513 | chr10:122263330 | ENST00000280333 | + | 8 | 52 | 1793_1819 | 255 | 1866 | NCK2 second and third SH3 domain (minor) |
| Hgene | DOCK1 | chr10:128796513 | chr10:122263330 | ENST00000280333 | + | 8 | 52 | 1820_1836 | 255 | 1866 | NCK2 third SH3 domain (major) |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DOCK1_PPAPDC1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOCK1_PPAPDC1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DOCK1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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