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Fusion gene ID: 10384 |
FusionGeneSummary for DOCK1_NPS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK1_NPS | Fusion gene ID: 10384 | Hgene | Tgene | Gene symbol | DOCK1 | NPS | Gene ID | 1793 | 594857 |
| Gene name | dedicator of cytokinesis 1 | neuropeptide S | |
| Synonyms | DOCK180|ced5 | - | |
| Cytomap | 10q26.2 | 10q26.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK | neuropeptide Sprepro-neuropeptide S | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q14185 | P0C0P6 | |
| Ensembl transtripts involved in fusion gene | ENST00000280333, ENST00000484400, | ENST00000398023, | |
| Fusion gene scores | * DoF score | 12 X 12 X 8=1152 | 1 X 2 X 2=4 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/1152*10)=-3.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: DOCK1 [Title/Abstract] AND NPS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A08O-01A | DOCK1 | chr10 | 129142010 | + | NPS | chr10 | 129347753 | + |
| TCGA | LD | OV | TCGA-61-1724-01A | DOCK1 | chr10 | 128780237 | + | NPS | chr10 | 129350724 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000280333 | ENST00000398023 | DOCK1 | chr10 | 129142010 | + | NPS | chr10 | 129347753 | + |
| 3UTR-3CDS | ENST00000484400 | ENST00000398023 | DOCK1 | chr10 | 129142010 | + | NPS | chr10 | 129347753 | + |
| Frame-shift | ENST00000280333 | ENST00000398023 | DOCK1 | chr10 | 128780237 | + | NPS | chr10 | 129350724 | + |
| intron-3CDS | ENST00000484400 | ENST00000398023 | DOCK1 | chr10 | 128780237 | + | NPS | chr10 | 129350724 | + |
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FusionProtFeatures for DOCK1_NPS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK1 | NPS |
| Involved in cytoskeletal rearrangements required forphagocytosis of apoptotic cells and cell motility. Along withDOCK1, mediates CRK/CRKL regulation of epithelial and endothelialcell spreading and migration on type IV collagen(PubMed:19004829). Functions as a guanine nucleotide exchangefactor (GEF), which activates Rac Rho small GTPases by exchangingbound GDP for free GTP. Its GEF activity may be enhanced by ELMO1(PubMed:8657152). {ECO:0000269|PubMed:19004829,ECO:0000269|PubMed:8657152}. | Modulates arousal and anxiety. May play an importantanorexigenic role (By similarity). Binds to its receptor NPSR1with nanomolar affinity to increase intracellular calciumconcentrations (PubMed:15312648, PubMed:16790440). {ECO:0000250,ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:16790440}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DOCK1 | chr10:129142010 | chr10:129347753 | ENST00000280333 | + | 31 | 52 | 425_609 | 1053 | 1866 | Domain | DHR-1 |
| Hgene | DOCK1 | chr10:129142010 | chr10:129347753 | ENST00000280333 | + | 31 | 52 | 9_70 | 1053 | 1866 | Domain | SH3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DOCK1 | chr10:129142010 | chr10:129347753 | ENST00000280333 | + | 31 | 52 | 1207_1617 | 1053 | 1866 | Domain | DHR-2 |
| Hgene | >DOCK1 | chr10:129142010 | chr10:129347753 | ENST00000280333 | + | 31 | 52 | 1687_1695 | 1053 | 1866 | Region | Phosphoinositide-binding |
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FusionGeneSequence for DOCK1_NPS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DOCK1_ENST00000280333_chr10_129142010_+_NPS_ENST00000398023_chr10_129347753_+_1141aa MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQ EVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTS TISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISENYLVRWSSSGLPK DIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVTDIINGKVDDEDKQHFIPFQPVAGENDF LQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDIYVTLVQGDFDKGSKTTAKNVEV TVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYD GTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQISTLVCSTKLTQNVDLLGLLKWRSNTS LLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLK NYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMMSSMSDQTVRVKGAALKYLPTIVNDVKL VFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLERQEDLEACCQLLSHILEVLYRKDVGPTQ RHVQIIMEKLLRTVNRTVISMGRDSELIGNFVACMTAILRQMEDYHYAHLIKTFGKMRTDVVDFLMETFIMFKNLIGKNVYPFDWVIMNM VQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNNSVKLNLILVLSLSTMHVFWCYPVPSS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DOCK1_ENST00000280333_chr10_129142010_+_NPS_ENST00000398023_chr10_129347753_+_3423nt ATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGGAGCGGATGAACTTTCTTTA CAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAAGTCTAAGAAGGGTATATTT CCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGGTGACCTCCCCCTCATCCAG GAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGATGTTTCGAAGTGTGCGGCAC ATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGAACTGAAGAAGAAGGTCACA GCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTTGGATCCAGAATTAACTAGC ACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATCTCAAAAGCAGAACATAGAT ATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTGTAAAATAGGAGAAGATGCT GAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTCCAGTTCAGGATTACCTAAA GACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAAAATCAGTTTTGTCTGTCAG ATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACCTTTTGGAGTGGCTGTGATG GATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGTGGCAGGGGAGAATGACTTC CTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAACATTGAAATTACTTCCTGGA GATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGGGTTTCCGGAGATAATCATG CCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAACAGCGAAGAACGTGGAGGTC ACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGCGATTTCAGAGTACAAATCT GTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGTTAACCGCAGTCACCTTCGG TTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGTCAAGCTGATGAGATACGAT GGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGCTGCCACGTACTTGAGTCTG CCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAGCTGCACCATTAGCAAGGAC TCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAAATGGCGCTCCAACACCAGC CTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACACGTTGGATGCCCTCTTCAAC ATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGGACTGATTGCTGATAGAAAA TTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAAGTTGACAAAAGTGTTGAAG AACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATCCATCTTCAAGTTCATCGTG CGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCAGCTCTTCAGGTCCATCAAT GACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGATCGTCAACGATGTGAAATTG GTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGACCATCCAGAAACTCTACTGC TTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGACCGATCAGCTCAAGTACCAT CTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAAGGACGTGGGGCCAACCCAG AGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGATTCTGAACTCATTGGAAAC TTCGTGGCTTGCATGACAGCTATTTTACGACAAATGGAAGATTACCATTATGCCCACTTGATCAAGACTTTTGGGAAAATGAGGACTGAT GTGGTAGATTTCCTAATGGAAACATTCATCATGTTTAAGAACCTCATTGGAAAGAACGTTTACCCCTTCGACTGGGTGATCATGAACATG GTGCAAAATAAAGTCTTCCTGCGAGCAATTAATCAGTATGCAGATATGCTGAACAAAAAATTTCTGGATCAAGCCAACTTTGAGCTACAG CTGTGGAACAACTACTTTCACCTGGCTGTTGCTTTCCTTACTCAAGAGTCCCTGCAACTGGAGAATTTTTCAAGTGCCAAGAGAGCCAAA ATCCTTAACAACTCAGTAAAACTCAATCTCATCCTAGTTCTGTCGCTGTCCACAATGCATGTGTTTTGGTGTTATCCAGTTCCATCTTCT AAGGTGTCTGGAAAATCTGATTACTTTCTCATTCTGCTGAACAGCTGCCCAACCAGATTGGACAGGAGCAAAGAACTAGCTTTTCTAAAG CCAATTTTGGAGAAGATGTTTGTGAAAAGGTCCTTTCGCAATGGAGTTGGCACAGGGATGAAAAAAACTTCCTTTCAAAGAGCAAAATCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DOCK1_ENST00000280333_chr10_129142010_+_NPS_ENST00000398023_chr10_129347753_+_3564nt CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTC CAGTTCAGGATTACCTAAAGACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAA AATCAGTTTTGTCTGTCAGATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACC TTTTGGAGTGGCTGTGATGGATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGT GGCAGGGGAGAATGACTTCCTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAAC ATTGAAATTACTTCCTGGAGATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGG GTTTCCGGAGATAATCATGCCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAAC AGCGAAGAACGTGGAGGTCACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGC GATTTCAGAGTACAAATCTGTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGT TAACCGCAGTCACCTTCGGTTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGT CAAGCTGATGAGATACGATGGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGC TGCCACGTACTTGAGTCTGCCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAG CTGCACCATTAGCAAGGACTCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAA ATGGCGCTCCAACACCAGCCTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACAC GTTGGATGCCCTCTTCAACATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGG ACTGATTGCTGATAGAAAATTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAA GTTGACAAAAGTGTTGAAGAACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATC CATCTTCAAGTTCATCGTGCGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCA GCTCTTCAGGTCCATCAATGACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGAT CGTCAACGATGTGAAATTGGTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGAC CATCCAGAAACTCTACTGCTTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGAC CGATCAGCTCAAGTACCATCTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAA GGACGTGGGGCCAACCCAGAGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGA TTCTGAACTCATTGGAAACTTCGTGGCTTGCATGACAGCTATTTTACGACAAATGGAAGATTACCATTATGCCCACTTGATCAAGACTTT TGGGAAAATGAGGACTGATGTGGTAGATTTCCTAATGGAAACATTCATCATGTTTAAGAACCTCATTGGAAAGAACGTTTACCCCTTCGA CTGGGTGATCATGAACATGGTGCAAAATAAAGTCTTCCTGCGAGCAATTAATCAGTATGCAGATATGCTGAACAAAAAATTTCTGGATCA AGCCAACTTTGAGCTACAGCTGTGGAACAACTACTTTCACCTGGCTGTTGCTTTCCTTACTCAAGAGTCCCTGCAACTGGAGAATTTTTC AAGTGCCAAGAGAGCCAAAATCCTTAACAACTCAGTAAAACTCAATCTCATCCTAGTTCTGTCGCTGTCCACAATGCATGTGTTTTGGTG TTATCCAGTTCCATCTTCTAAGGTGTCTGGAAAATCTGATTACTTTCTCATTCTGCTGAACAGCTGCCCAACCAGATTGGACAGGAGCAA AGAACTAGCTTTTCTAAAGCCAATTTTGGAGAAGATGTTTGTGAAAAGGTCCTTTCGCAATGGAGTTGGCACAGGGATGAAAAAAACTTC |
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FusionGenePPI for DOCK1_NPS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DOCK1 | RHOG, BCAR1, CRK, GRB2, SRC, PTK2, ELMO1, RAC1, NCK2, MEPCE, MAP1LC3B, CUL1, FBXW11, BTRC, NTRK1, CRKL, SNW1, ARL4A, ELMO3, RAC2, PRKACA | NPS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | DOCK1 | chr10:129142010 | chr10:129347753 | ENST00000280333 | + | 31 | 52 | 1837_1852 | 1053 | 1866 | NCK2 (minor) |
| Hgene | DOCK1 | chr10:129142010 | chr10:129347753 | ENST00000280333 | + | 31 | 52 | 1793_1819 | 1053 | 1866 | NCK2 second and third SH3 domain (minor) |
| Hgene | DOCK1 | chr10:129142010 | chr10:129347753 | ENST00000280333 | + | 31 | 52 | 1820_1836 | 1053 | 1866 | NCK2 third SH3 domain (major) |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DOCK1_NPS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOCK1_NPS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DOCK1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | NPS | C0236736 | Cocaine-Related Disorders | 3 | CTD_human |
| Tgene | NPS | C0003469 | Anxiety Disorders | 2 | CTD_human |
| Tgene | NPS | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | NPS | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | NPS | C0011581 | Depressive disorder | 1 | PSYGENET |
| Tgene | NPS | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | NPS | C0424295 | Hyperactive behavior | 1 | CTD_human |
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