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Fusion gene ID: 10367 |
FusionGeneSummary for DOCK10_EVA1A |
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Fusion gene information | Fusion gene name: DOCK10_EVA1A | Fusion gene ID: 10367 | Hgene | Tgene | Gene symbol | DOCK10 | EVA1A | Gene ID | 55619 | 84141 |
Gene name | dedicator of cytokinesis 10 | eva-1 homolog A, regulator of programmed cell death | |
Synonyms | DRIP2|Nbla10300|ZIZ3 | FAM176A|TMEM166 | |
Cytomap | 2q36.2 | 2p12 | |
Type of gene | protein-coding | protein-coding | |
Description | dedicator of cytokinesis protein 10dopamine receptor interacting protein 2zizimin3 | protein eva-1 homolog Afamily with sequence similarity 176, member Aprotein FAM176Atransmembrane protein 166 | |
Modification date | 20180526 | 20180523 | |
UniProtAcc | Q96BY6 | Q9H8M9 | |
Ensembl transtripts involved in fusion gene | ENST00000409592, ENST00000258390, ENST00000474102, | ENST00000490746, ENST00000393913, ENST00000233712, ENST00000410113, ENST00000410071, ENST00000410010, | |
Fusion gene scores | * DoF score | 7 X 6 X 2=84 | 2 X 2 X 1=4 |
# samples | 7 | 2 | |
** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: DOCK10 [Title/Abstract] AND EVA1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DOCK10 | GO:0030334 | regulation of cell migration | 18835169 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI989611 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000409592 | ENST00000490746 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000409592 | ENST00000393913 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000409592 | ENST00000233712 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000409592 | ENST00000410113 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000409592 | ENST00000410071 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000409592 | ENST00000410010 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000258390 | ENST00000490746 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000258390 | ENST00000393913 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000258390 | ENST00000233712 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000258390 | ENST00000410113 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000258390 | ENST00000410071 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000258390 | ENST00000410010 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000474102 | ENST00000490746 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000474102 | ENST00000393913 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000474102 | ENST00000233712 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000474102 | ENST00000410113 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000474102 | ENST00000410071 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
intron-intron | ENST00000474102 | ENST00000410010 | DOCK10 | chr2 | 225719792 | - | EVA1A | chr2 | 75790608 | + |
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FusionProtFeatures for DOCK10_EVA1A |
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Hgene | Tgene |
DOCK10 | EVA1A |
Guanine nucleotide-exchange factor (GEF) that activatesCDC42 and RAC1 by exchanging bound GDP for free GTP. Essential fordendritic spine morphogenesis in Purkinje cells and in hippocampalneurons, via a CDC42-mediated pathway. Sustains B-celllymphopoiesis in secondary lymphoid tissues and regulatesFCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. | Acts as a regulator of programmed cell death, mediatingboth autophagy and apoptosis. {ECO:0000269|PubMed:17492404,ECO:0000269|PubMed:19029833}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DOCK10_EVA1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DOCK10_EVA1A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DOCK10_EVA1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOCK10_EVA1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DOCK10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |