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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10367

FusionGeneSummary for DOCK10_EVA1A

check button Fusion gene summary
Fusion gene informationFusion gene name: DOCK10_EVA1A
Fusion gene ID: 10367
HgeneTgene
Gene symbol

DOCK10

EVA1A

Gene ID

55619

84141

Gene namededicator of cytokinesis 10eva-1 homolog A, regulator of programmed cell death
SynonymsDRIP2|Nbla10300|ZIZ3FAM176A|TMEM166
Cytomap

2q36.2

2p12

Type of geneprotein-codingprotein-coding
Descriptiondedicator of cytokinesis protein 10dopamine receptor interacting protein 2zizimin3protein eva-1 homolog Afamily with sequence similarity 176, member Aprotein FAM176Atransmembrane protein 166
Modification date2018052620180523
UniProtAcc

Q96BY6

Q9H8M9

Ensembl transtripts involved in fusion geneENST00000409592, ENST00000258390, 
ENST00000474102, 		ENST00000490746, 
ENST00000393913, ENST00000233712, 
ENST00000410113, ENST00000410071, 
ENST00000410010, 
Fusion gene scores* DoF score7 X 6 X 2=842 X 2 X 1=4
# samples 72
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: DOCK10 [Title/Abstract] AND EVA1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDOCK10

GO:0030334

regulation of cell migration

18835169


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI989611DOCK10chr2

225719792

-EVA1Achr2

75790608

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409592ENST00000490746DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000409592ENST00000393913DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000409592ENST00000233712DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000409592ENST00000410113DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000409592ENST00000410071DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000409592ENST00000410010DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000258390ENST00000490746DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000258390ENST00000393913DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000258390ENST00000233712DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000258390ENST00000410113DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000258390ENST00000410071DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000258390ENST00000410010DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000474102ENST00000490746DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000474102ENST00000393913DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000474102ENST00000233712DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000474102ENST00000410113DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000474102ENST00000410071DOCK10chr2

225719792

-EVA1Achr2

75790608

+
intron-intronENST00000474102ENST00000410010DOCK10chr2

225719792

-EVA1Achr2

75790608

+

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FusionProtFeatures for DOCK10_EVA1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DOCK10

Q96BY6

EVA1A

Q9H8M9

Guanine nucleotide-exchange factor (GEF) that activatesCDC42 and RAC1 by exchanging bound GDP for free GTP. Essential fordendritic spine morphogenesis in Purkinje cells and in hippocampalneurons, via a CDC42-mediated pathway. Sustains B-celllymphopoiesis in secondary lymphoid tissues and regulatesFCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. Acts as a regulator of programmed cell death, mediatingboth autophagy and apoptosis. {ECO:0000269|PubMed:17492404,ECO:0000269|PubMed:19029833}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DOCK10_EVA1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DOCK10_EVA1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DOCK10_EVA1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DOCK10_EVA1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDOCK10C0023893Liver Cirrhosis, Experimental1CTD_human