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Fusion gene ID: 10366 |
FusionGeneSummary for DOC2B_APBB2 |
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Fusion gene information | Fusion gene name: DOC2B_APBB2 | Fusion gene ID: 10366 | Hgene | Tgene | Gene symbol | DOC2B | APBB2 | Gene ID | 8447 | 323 |
Gene name | double C2 domain beta | amyloid beta precursor protein binding family B member 2 | |
Synonyms | DOC2BL | FE65L|FE65L1 | |
Cytomap | 17p13.3 | 4p14-p13 | |
Type of gene | protein-coding | protein-coding | |
Description | double C2-like domain-containing protein betadoc2-betadouble C2-like domains, beta | amyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14184 | Q92870 | |
Ensembl transtripts involved in fusion gene | ENST00000343572, ENST00000609727, | ENST00000295974, ENST00000513140, ENST00000508593, ENST00000506352, ENST00000511572, ENST00000543538, ENST00000502841, ENST00000504305, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 6=150 |
# samples | 1 | 8 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DOC2B [Title/Abstract] AND APBB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-91-6831-01A | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000343572 | ENST00000295974 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000343572 | ENST00000513140 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000343572 | ENST00000508593 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000343572 | ENST00000506352 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000343572 | ENST00000511572 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-intron | ENST00000343572 | ENST00000543538 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-intron | ENST00000343572 | ENST00000502841 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-intron | ENST00000343572 | ENST00000504305 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000609727 | ENST00000295974 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000609727 | ENST00000513140 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000609727 | ENST00000508593 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000609727 | ENST00000506352 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-5UTR | ENST00000609727 | ENST00000511572 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-intron | ENST00000609727 | ENST00000543538 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-intron | ENST00000609727 | ENST00000502841 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
intron-intron | ENST00000609727 | ENST00000504305 | DOC2B | chr17 | 6011 | - | APBB2 | chr4 | 41102767 | - |
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FusionProtFeatures for DOC2B_APBB2 |
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Hgene | Tgene |
DOC2B | APBB2 |
Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipidsin a calcium-dependent manner and may act at the priming stage offusion by modifying membrane curvature to stimulate fusion.Involved in calcium-triggered exocytosis in chromaffin cells andcalcium-dependent spontaneous release of neurotransmitter inabsence of action potentials in neuronal cells. Involved both inglucose-stimulated insulin secretion in pancreatic cells andinsulin-dependent GLUT4 transport to the plasma membrane inadipocytes (By similarity). {ECO:0000250,ECO:0000269|PubMed:9804756}. | May modulate the internalization of amyloid-betaprecursor protein. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DOC2B_APBB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DOC2B_APBB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DOC2B | DOC2A, RPH3A | APBB2 | APP, EGFR, HSPA8, TBC1D4, OSBPL2, APLP2, APBB1, AKAP1, GOPC, TUBA1A, APLP1, CBWD1, APOL2, RAP1GDS1, SYDE2, ATP7A, WDR41, TBC1D2B, FMN2, QTRT1, LDHAL6B, WISP3, NCK1, SORT1, SYNCRIP, MRPL1, GAN, TMEM30B, ADCYAP1, VAV1, HGFAC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DOC2B_APBB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOC2B_APBB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | APBB2 | C0043094 | Weight Gain | 1 | CTD_human |