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Fusion gene ID: 10353 |
FusionGeneSummary for DNMT3A_ADCY3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNMT3A_ADCY3 | Fusion gene ID: 10353 | Hgene | Tgene | Gene symbol | DNMT3A | ADCY3 | Gene ID | 1788 | 114 |
| Gene name | DNA methyltransferase 3 alpha | adenylate cyclase 8 | |
| Synonyms | DNMT3A2|M.HsaIIIA|TBRS | AC8|ADCY3|HBAC1 | |
| Cytomap | 2p23.3 | 8q24.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA (cytosine-5)-methyltransferase 3ADNA (cytosine-5-)-methyltransferase 3 alphaDNA MTase HsaIIIADNA cytosine methyltransferase 3A2 | adenylate cyclase type 8ATP pyrophosphate-lyase 8HEL-S-172mPadenylate cyclase 8 (brain)adenylate cyclase type VIIIadenylyl cyclase 8adenylyl cyclase-8, brainca(2+)/calmodulin-activated adenylyl cyclaseepididymis secretory sperm binding protein Li | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q9Y6K1 | O60266 | |
| Ensembl transtripts involved in fusion gene | ENST00000321117, ENST00000264709, ENST00000406659, ENST00000380746, ENST00000402667, ENST00000474887, | ENST00000260600, ENST00000405392, ENST00000450524, | |
| Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DNMT3A [Title/Abstract] AND ADCY3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNMT3A | GO:0006306 | DNA methylation | 12138111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A7-A4SD-01A | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shit | ENST00000321117 | ENST00000260600 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| 5CDS-intron | ENST00000321117 | ENST00000405392 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| 5CDS-intron | ENST00000321117 | ENST00000450524 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| Frame-shit | ENST00000264709 | ENST00000260600 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| 5CDS-intron | ENST00000264709 | ENST00000405392 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| 5CDS-intron | ENST00000264709 | ENST00000450524 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| Frame-shit | ENST00000406659 | ENST00000260600 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| 5CDS-intron | ENST00000406659 | ENST00000405392 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| 5CDS-intron | ENST00000406659 | ENST00000450524 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-3CDS | ENST00000380746 | ENST00000260600 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-intron | ENST00000380746 | ENST00000405392 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-intron | ENST00000380746 | ENST00000450524 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-3CDS | ENST00000402667 | ENST00000260600 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-intron | ENST00000402667 | ENST00000405392 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-intron | ENST00000402667 | ENST00000450524 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-3CDS | ENST00000474887 | ENST00000260600 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-intron | ENST00000474887 | ENST00000405392 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
| intron-intron | ENST00000474887 | ENST00000450524 | DNMT3A | chr2 | 25523008 | - | ADCY3 | chr2 | 25065253 | - |
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FusionProtFeatures for DNMT3A_ADCY3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNMT3A | ADCY3 |
| Required for genome-wide de novo methylation and isessential for the establishment of DNA methylation patterns duringdevelopment. DNA methylation is coordinated with methylation ofhistones. It modifies DNA in a non-processive manner and alsomethylates non-CpG sites. May preferentially methylate DNA linkerbetween 2 nucleosomal cores and is inhibited by histone H1. Playsa role in paternal and maternal imprinting. Required formethylation of most imprinted loci in germ cells. Acts as atranscriptional corepressor for ZBTB18. Recruited to trimethylated'Lys-36' of histone H3 (H3K36me3) sites. Can actively represstranscription through the recruitment of HDAC activity.{ECO:0000269|PubMed:16357870}. | Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling. Participates in signalingcascades triggered by odorant receptors via its function in cAMPbiosynthesis. Required for the perception of odorants. Requiredfor normal sperm motility and normal male fertility. Plays a rolein regulating insulin levels and body fat accumulation in responseto a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNMT3A_ADCY3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNMT3A_ADCY3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DNMT3A | UBE2I, MYC, ZBTB17, PIAS1, PIAS2, DNMT3B, CBX5, SUV39H1, CBX1, ZBTB18, HDAC1, RB1, DNMT3L, DNMT1, SPI1, HIST1H3E, PRMT5, HIST1H3A, UHRF1, SETDB1, EZH2, EED, CBX4, USP7, UHRF2, TRIM28, ZFP57, SALL3, F8A1, IRF9, TFAP2A, EHMT2, EHMT1, MPHOSPH8, TERF2IP, DAXX, NRIP1, PAF1, CDC73, POLR2H, POLR2C, POLR2A, RTF1, LEO1, CTR9, PTGES3, SP100, TCL1A, HIST1H2BG, TRIM25 | ADCY3 | ADRB2, POPDC2, LGALS3, ANKMY2, SLC4A8, ASIC4, CNGA3, IL17RC, PCDHGA5, CD79B, IZUMO1, SLC17A2, KCNA5, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNMT3A_ADCY3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNMT3A_ADCY3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DNMT3A | C0079774 | Peripheral T-Cell Lymphoma | 2 | CTD_human |
| Hgene | DNMT3A | C0010346 | Crohn Disease | 1 | CTD_human |
| Hgene | DNMT3A | C0018273 | Growth Disorders | 1 | CTD_human |
| Hgene | DNMT3A | C0020981 | Angioimmunoblastic Lymphadenopathy | 1 | CTD_human |
| Hgene | DNMT3A | C0023465 | Acute monocytic leukemia | 1 | CTD_human |
| Hgene | DNMT3A | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
| Hgene | DNMT3A | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | DNMT3A | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| Hgene | DNMT3A | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Hgene | DNMT3A | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Hgene | DNMT3A | C0282631 | Facies | 1 | CTD_human |
| Hgene | DNMT3A | C0349639 | Juvenile Myelomonocytic Leukemia | 1 | CTD_human |
| Hgene | DNMT3A | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Hgene | DNMT3A | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | DNMT3A | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Hgene | DNMT3A | C3496069 | cocaine use | 1 | PSYGENET |
| Hgene | DNMT3A | C3714756 | Intellectual Disability | 1 | CTD_human |
| Hgene | DNMT3A | C4014545 | TATTON-BROWN-RAHMAN SYNDROME | 1 | ORPHANET;UNIPROT |
| Tgene | ADCY3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | ADCY3 | C0011875 | Diabetic Angiopathies | 1 | CTD_human |
| Tgene | ADCY3 | C0525045 | Mood Disorders | 1 | PSYGENET |
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