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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 10345

FusionGeneSummary for DNMT1_FDX1L

check button Fusion gene summary
Fusion gene informationFusion gene name: DNMT1_FDX1L
Fusion gene ID: 10345
HgeneTgene
Gene symbol

DNMT1

FDX1L

Gene ID

1786

112812

Gene nameDNA methyltransferase 1ferredoxin 2
SynonymsADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|m.HsaIFDX1L
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 1CXXC-type zinc finger protein 9DNA (cytosine-5-)-methyltransferase 1DNA MTase HsaIDNA methyltransferase HsaIferredoxin-2, mitochondrialadrenodoxin-like protein, mitochondrialferredoxin 1 like
Modification date2018052720180519
UniProtAcc

P26358

Ensembl transtripts involved in fusion geneENST00000340748, ENST00000540357, 
ENST00000359526, ENST00000589538, 
ENST00000541276, ENST00000393708, 
ENST00000492239, ENST00000494368, 
Fusion gene scores* DoF score10 X 9 X 9=8103 X 3 X 3=27
# samples 124
** MAII scorelog2(12/810*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNMT1 [Title/Abstract] AND FDX1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT1

GO:0010216

maintenance of DNA methylation

18754681|21745816


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A3A5-01ADNMT1chr19

10283766

-FDX1Lchr19

10421616

-
TCGARVUVMTCGA-V4-A9EX-01ADNMT1chr19

10283766

-FDX1Lchr19

10426435

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000340748ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
Frame-shiftENST00000340748ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000340748ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000340748ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
In-frameENST00000540357ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
Frame-shiftENST00000540357ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000540357ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000540357ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
In-frameENST00000359526ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
Frame-shiftENST00000359526ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000359526ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000359526ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
intron-3CDSENST00000589538ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
intron-3CDSENST00000589538ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
intron-5UTRENST00000589538ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
intron-5UTRENST00000589538ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
In-frameENST00000340748ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
Frame-shiftENST00000340748ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000340748ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000340748ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
In-frameENST00000540357ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
Frame-shiftENST00000540357ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000540357ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000540357ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
In-frameENST00000359526ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
Frame-shiftENST00000359526ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000359526ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000359526ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
intron-3CDSENST00000589538ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
intron-3CDSENST00000589538ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
intron-5UTRENST00000589538ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
intron-5UTRENST00000589538ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10426435

-

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FusionProtFeatures for DNMT1_FDX1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT1

P26358

FDX1L

Methylates CpG residues. Preferentially methylateshemimethylated DNA. Associates with DNA replication sites in Sphase maintaining the methylation pattern in the newly synthesizedstrand, that is essential for epigenetic inheritance. Associateswith chromatin during G2 and M phases to maintain DNA methylationindependently of replication. It is responsible for maintainingmethylation patterns established in development. DNA methylationis coordinated with methylation of histones. Mediatestranscriptional repression by direct binding to HDAC2. Inassociation with DNMT3B and via the recruitment of CTCFL/BORIS,involved in activation of BAG1 gene expression by modulatingdimethylation of promoter histone H3 at H3K4 and H3K9. Probablyforms a corepressor complex required for activated KRAS-mediatedpromoter hypermethylation and transcriptional silencing of tumorsuppressor genes (TSGs) or other tumor-related genes in colorectalcancer (CRC) cells (PubMed:24623306). Also required to maintain atranscriptionally repressive state of genes in undifferentiatedembryonic stem cells (ESCs) (PubMed:24623306). Associates atpromoter regions of tumor suppressor genes (TSGs) leading to theirgene silencing (PubMed:24623306). Promotes tumor growth(PubMed:24623306). {ECO:0000269|PubMed:16357870,ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681,ECO:0000269|PubMed:24623306}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840177_2052401617MotifNuclear localization signal
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941177_2052561633MotifNuclear localization signal
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840177_2052401617MotifNuclear localization signal
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941177_2052561633MotifNuclear localization signal
TgeneFDX1Lchr19:10283766chr19:10426435ENST00000393708-0568_17048184Domain2Fe-2S ferredoxin-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401139_15992401617DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840755_8802401617DomainBAH 1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840972_11002401617DomainBAH 2
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411139_15992561633DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941755_8802561633DomainBAH 1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941972_11002561633DomainBAH 2
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401139_15992401617DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840755_8802401617DomainBAH 1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840972_11002401617DomainBAH 2
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411139_15992561633DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941755_8802561633DomainBAH 1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941972_11002561633DomainBAH 2
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401109_11202401617RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401139_16162401617RegionNote=Catalytic
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401150_11512401617RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401168_11692401617RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401190_11912401617RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840310_5022401617RegionNote=Homodimerization
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840331_5502401617RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840651_6972401617RegionNote=Required for activity
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840693_7542401617RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411109_11202561633RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411139_16162561633RegionNote=Catalytic
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411150_11512561633RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411168_11692561633RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411190_11912561633RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941310_5022561633RegionNote=Homodimerization
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941331_5502561633RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941651_6972561633RegionNote=Required for activity
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941693_7542561633RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401109_11202401617RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401139_16162401617RegionNote=Catalytic
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401150_11512401617RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401168_11692401617RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401190_11912401617RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840310_5022401617RegionNote=Homodimerization
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840331_5502401617RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840651_6972401617RegionNote=Required for activity
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840693_7542401617RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411109_11202561633RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411139_16162561633RegionNote=Catalytic
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411150_11512561633RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411168_11692561633RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411190_11912561633RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941310_5022561633RegionNote=Homodimerization
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941331_5502561633RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941651_6972561633RegionNote=Required for activity
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941693_7542561633RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401109_11102401617RepeatNote=1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401111_11122401617RepeatNote=2
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401113_11142401617RepeatNote=3
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401115_11162401617RepeatNote=4
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401117_11182401617RepeatNote=5
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401119_11202401617RepeatNote=6%3B approximate
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411109_11102561633RepeatNote=1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411111_11122561633RepeatNote=2
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411113_11142561633RepeatNote=3
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411115_11162561633RepeatNote=4
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411117_11182561633RepeatNote=5
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411119_11202561633RepeatNote=6%3B approximate
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401109_11102401617RepeatNote=1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401111_11122401617RepeatNote=2
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401113_11142401617RepeatNote=3
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401115_11162401617RepeatNote=4
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401117_11182401617RepeatNote=5
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401119_11202401617RepeatNote=6%3B approximate
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411109_11102561633RepeatNote=1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411111_11122561633RepeatNote=2
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411113_11142561633RepeatNote=3
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411115_11162561633RepeatNote=4
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411117_11182561633RepeatNote=5
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411119_11202561633RepeatNote=6%3B approximate
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840646_6922401617Zinc fingerCXXC-type
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941646_6922561633Zinc fingerCXXC-type
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840646_6922401617Zinc fingerCXXC-type
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941646_6922561633Zinc fingerCXXC-type
TgeneFDX1Lchr19:10283766chr19:10421616ENST00000393708-2568_170102184Domain2Fe-2S ferredoxin-type


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FusionGeneSequence for DNMT1_FDX1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DNMT1_ENST00000340748_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_240aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP

>In-frame_DNMT1_ENST00000540357_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_240aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP

>In-frame_DNMT1_ENST00000359526_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_256aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ

>In-frame_DNMT1_ENST00000340748_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_240aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP

>In-frame_DNMT1_ENST00000540357_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_240aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP

>In-frame_DNMT1_ENST00000359526_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_256aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DNMT1_ENST00000340748_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_720nt
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA

>In-frame_DNMT1_ENST00000540357_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_720nt
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA

>In-frame_DNMT1_ENST00000359526_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_768nt
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCGTTCA
AGAGACCCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTAGAGCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAA
ACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAG
GAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGA

>In-frame_DNMT1_ENST00000340748_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_720nt
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA

>In-frame_DNMT1_ENST00000540357_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_720nt
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA

>In-frame_DNMT1_ENST00000359526_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_768nt
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCGTTCA
AGAGACCCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTAGAGCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAA
ACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAG
GAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_DNMT1_ENST00000340748_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_2754nt
TCCGCGTGGGGGGGGTGTGTGCCCGCCTTGCGCATGCGTGTTCCCTGGGCATGGCCGGCTCCGTTCCATCCTTCTGCACAGGGTATCGCC
TCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGCCGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCC
GCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAGATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCA
CACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGACAGCTTAACAGAAAAGGAATGTG
TGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAGTTATGTGACTTGGAAACCAAATTACGTAAAGAAG
AATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGTGCTCATGCTTACAACCGGG
AAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTGGGAATGGCAGATGCCAACAGCCCCCCCAAACCCC
TTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCA
CCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGT
CCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAAC
CTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGCTCGCGCCCGGCTGGAGAGGAGGACGCGGGCGG
CCCGGAGCGGCCCGGGGACGTGGTGAACGTGGTGTTCGTAGACCGCTCAGGCCAGCGGATCCCAGTGAGTGGCAGAGTCGGGGACAATGT
TCTTCACCTGGCCCAGCGCCACGGGGTGGACCTGGAAGGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGTATGTGAGTGA
AGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCTGGAAGGAGCG
GAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGACCATTCCACA
TTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCC
CTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACTCATATTGGAG
CTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACACCTGTAATCCT
AGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCGTCTCTATAAA
AACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTGAGCCCAGGGG
ATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAA
ACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGGATCCAAGGCA
GAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCC
GCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTC
ATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGG
CTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCG
GTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAGGGCCGCCGTC
TGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGAGTGGACCCTG
GGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTT
CTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAGGCCCTGGAGC

>In-frame_DNMT1_ENST00000540357_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_2698nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA
GCTCGCGCCCGGCTGGAGAGGAGGACGCGGGCGGCCCGGAGCGGCCCGGGGACGTGGTGAACGTGGTGTTCGTAGACCGCTCAGGCCAGC
GGATCCCAGTGAGTGGCAGAGTCGGGGACAATGTTCTTCACCTGGCCCAGCGCCACGGGGTGGACCTGGAAGGGGCCTGTGAAGCCTCCC
TGGCCTGCTCCACCTGCCATGTGTATGTGAGTGAAGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTG
CCAGATTGTGCTGACACCGGAGCTGGAAGGAGCGGAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAA
GCCCCACTGACATGAACACCTGGACCATTCCACATTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAG
AGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCCCTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAA
TCAGGGTTTGAGTAGGAGTGGACTCATATTGGAGCTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGAT
CTGGGGTCTACAGGTGGCTCACACCTGTAATCCTAGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCAT
CCTGGGCAACATGGCGAGACCTCGTCTCTATAAAAACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGG
AGACTGAGGTGGGAGGATCACTTGAGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGA
GTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAAACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCT
CTGGGATCTAAGATGCCGCTGGGGATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCC
GGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGG
TGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTCATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAA
GCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAG
TGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGAC
ACACAGACCAGGATCAGCCAAAAGGGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTG
AACCCCTGCCGGGGCACCGAGAGAGTGGACCCTGGGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATC
ATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTTCTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACC

>In-frame_DNMT1_ENST00000359526_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10426435_-_2746nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCGTTCA
AGAGACCCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTAGAGCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAA
ACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAG
GAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGA
GCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGCTCGCGCCCGGCTGGAGAGGAGGACGCGGGCGGCCCGGAGC
GGCCCGGGGACGTGGTGAACGTGGTGTTCGTAGACCGCTCAGGCCAGCGGATCCCAGTGAGTGGCAGAGTCGGGGACAATGTTCTTCACC
TGGCCCAGCGCCACGGGGTGGACCTGGAAGGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGTATGTGAGTGAAGACCACC
TGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCTGGAAGGAGCGGAATTCAC
CCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGACCATTCCACATTGCCATG
GCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCCCTGTGAAG
GACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACTCATATTGGAGCTGCAATA
AATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACACCTGTAATCCTAGCACTTT
GGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCGTCTCTATAAAAACAGTAA
AAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTGAGCCCAGGGGATTTAGGC
TGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAAACAAAAAC
AAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGGATCCAAGGCAGAGGCCTG
GGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCCGCCCTTGC
CACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTCATCGCATC
CTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGGCTGGGAGG
ATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCGGTCACCGC
CCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAGGGCCGCCGTCTGCAGCCC
CCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGAGTGGACCCTGGGTTCGAG
GGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTTCTCAGGAA
TCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAGGCCCTGGAGCCCCGGCGC

>In-frame_DNMT1_ENST00000340748_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_2592nt
TCCGCGTGGGGGGGGTGTGTGCCCGCCTTGCGCATGCGTGTTCCCTGGGCATGGCCGGCTCCGTTCCATCCTTCTGCACAGGGTATCGCC
TCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGCCGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCC
GCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAGATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCA
CACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGACAGCTTAACAGAAAAGGAATGTG
TGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAGTTATGTGACTTGGAAACCAAATTACGTAAAGAAG
AATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGTGCTCATGCTTACAACCGGG
AAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTGGGAATGGCAGATGCCAACAGCCCCCCCAAACCCC
TTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCA
CCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGT
CCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAAC
CTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTG
CCATGTGTATGTGAGTGAAGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACA
CCGGAGCTGGAAGGAGCGGAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAA
CACCTGGACCATTCCACATTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCG
GGAGAGACGTGGAAGCCCCTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGG
AGTGGACTCATATTGGAGCTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTG
GCTCACACCTGTAATCCTAGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCG
AGACCTCGTCTCTATAAAAACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGG
ATCACTTGAGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCA
AAAAAAAAAAAAACAAAAACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGC
CGCTGGGGATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGA
TTTGGTGGGGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGT
CGCTCTCAGCTGGGGCTCATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCC
TGTCTGAACCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGG
CCTGCATGCCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCA
GCCAAAAGGGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCA
CCGAGAGAGTGGACCCTGGGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCC
TGCCCTGCAGTAGCCGTTCTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAG

>In-frame_DNMT1_ENST00000540357_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_2536nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA
GGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGTATGTGAGTGAAGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGA
GAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCTGGAAGGAGCGGAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGT
GGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGACCATTCCACATTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCA
GGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCCCTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCA
TGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACTCATATTGGAGCTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAG
TGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACACCTGTAATCCTAGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGG
CCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCGTCTCTATAAAAACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTG
TAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTGAGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCAC
TCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAAACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCC
CCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGGATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAG
CGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAA
AGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTCATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGT
CCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCC
AGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAG
GCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAGGGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGA
AGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGAGTGGACCCTGGGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCG
GACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTTCTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCA
GCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAGGCCCTGGAGCCCCGGCGCTGTGCTTCCTGTCGGACCCAGAGGACCCCG

>In-frame_DNMT1_ENST00000359526_chr19_10283766_-_FDX1L_ENST00000541276_chr19_10421616_-_2584nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCGTTCA
AGAGACCCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTAGAGCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAA
ACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAG
GAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGA
GCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGT
ATGTGAGTGAAGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCT
GGAAGGAGCGGAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGA
CCATTCCACATTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGAC
GTGGAAGCCCCTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACT
CATATTGGAGCTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACAC
CTGTAATCCTAGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCG
TCTCTATAAAAACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTG
AGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAA
AAAAACAAAAACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGG
ATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGG
GGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCA
GCTGGGGCTCATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAA
CCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATG
CCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAG
GGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGA
GTGGACCCTGGGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGC
AGTAGCCGTTCTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAG


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FusionGenePPI for DNMT1_FDX1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNMT1RGS6, DNMT3B, CBX5, SUV39H1, CBX1, PCNA, HDAC2, DMAP1, RB1, E2F1, HDAC1, TRIM27, DNMT3A, UHRF1, MBD2, MECP2, CXXC1, USP7, SETD7, SP1, SP3, EHMT2, EZH2, EED, BAZ2A, STAT3, SMARCA5, TP53, CHEK1, HELLS, WT1, SUZ12, TCF3, HSPA4, SNRPG, HSPA5, RAD9A, AKT1, KAT5, GSK3B, CSNK2B, RPS6KA6, DAXX, GADD45A, UHRF2, TRIM28, ZFP57, SIRT1, DNMT1, RUNX1T1, RUNX1, SIRT7, SH3KBP1, KDM1A, NR2C1, NR2C2, MTA1, MTA2, CHD4, RBBP4, MBD3, POLD3, HDAC3, CBX6, RELB, KIAA0101, NRIP1, CTBP1, YWHAQ, PARP1, BRCA1, CDKL4, DNAJC2, GCN1L1, ZFR, NTRK1, HIST3H3, HIST2H2AC, B9D2, HIST1H3E, CDK2, MYH14, BRAP, MKL1, CCNB1, SNAI1, CDC14B, LASP1, FOXA1, BRD1, PRKAA2, RBBP7FDX1LAPP, FDX1, LHX4, GFPT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401_1202401617DMAP1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411_1202561633DMAP1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401_1202401617DMAP1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411_1202561633DMAP1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401_1482401617DNMT3A
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411_1482561633DNMT3A
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401_1482401617DNMT3A
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411_1482561633DNMT3A
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840149_2172401617DNMT3B
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941149_2172561633DNMT3B
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840149_2172401617DNMT3B
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941149_2172561633DNMT3B
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840163_1742401617PCNA
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941163_1742561633PCNA
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840163_1742401617PCNA
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941163_1742561633PCNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401121_16162401617the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840308_6062401617the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411121_16162561633the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941308_6062561633the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401121_16162401617the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840308_6062401617the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411121_16162561633the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941308_6062561633the PRC2/EED-EZH2 complex


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNMT1_FDX1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDNMT1P26358DB01035ProcainamideDNA (cytosine-5)-methyltransferase 1small moleculeapproved
HgeneDNMT1P26358DB00928AzacitidineDNA (cytosine-5)-methyltransferase 1small moleculeapproved|investigational
HgeneDNMT1P26358DB01099FlucytosineDNA (cytosine-5)-methyltransferase 1small moleculeapproved|investigational
HgeneDNMT1P26358DB01262DecitabineDNA (cytosine-5)-methyltransferase 1small moleculeapproved|investigational

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RelatedDiseases for DNMT1_FDX1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNMT1C0036341Schizophrenia4PSYGENET
HgeneDNMT1C0005586Bipolar Disorder2PSYGENET
HgeneDNMT1C0038356Stomach Neoplasms2CTD_human
HgeneDNMT1C0001418Adenocarcinoma1CTD_human
HgeneDNMT1C0003469Anxiety Disorders1CTD_human
HgeneDNMT1C0004096Asthma1CTD_human
HgeneDNMT1C0009375Colonic Neoplasms1CTD_human
HgeneDNMT1C0025149Medulloblastoma1CTD_human
HgeneDNMT1C0027889Hereditary Sensory and Autonomic Neuropathies1CTD_human
HgeneDNMT1C0033578Prostatic Neoplasms1CTD_human
HgeneDNMT1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneDNMT1C0497327Dementia1CTD_human;HPO
HgeneDNMT1C0525045Mood Disorders1PSYGENET
HgeneDNMT1C0993582Arthritis, Experimental1CTD_human
HgeneDNMT1C1384666hearing impairment1CTD_human
HgeneDNMT1C1458155Mammary Neoplasms1CTD_human
HgeneDNMT1C3279885Hereditary Sensory and Autonomic Neuropathy Type Ie1ORPHANET;UNIPROT
HgeneDNMT1C3807295CEREBELLAR ATAXIA, DEAFNESS, AND NARCOLEPSY, AUTOSOMAL DOMINANT1ORPHANET;UNIPROT