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Fusion gene ID: 1032 |
FusionGeneSummary for AFG3L2_TIAM1 |
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Fusion gene information | Fusion gene name: AFG3L2_TIAM1 | Fusion gene ID: 1032 | Hgene | Tgene | Gene symbol | AFG3L2 | TIAM1 | Gene ID | 10939 | 7074 |
Gene name | AFG3 like matrix AAA peptidase subunit 2 | T cell lymphoma invasion and metastasis 1 | |
Synonyms | SCA28|SPAX5 | TIAM-1 | |
Cytomap | 18p11.21 | 21q22.11 | |
Type of gene | protein-coding | protein-coding | |
Description | AFG3-like protein 2AFG3 ATPase family gene 3-like 2AFG3 ATPase family member 3-like 2AFG3 like AAA ATPase 2ATPase family gene 3, yeastparaplegin-like protein | T-lymphoma invasion and metastasis-inducing protein 1human T-lymphoma invasion and metastasis inducing TIAM1 protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9Y4W6 | Q13009 | |
Ensembl transtripts involved in fusion gene | ENST00000269143, | ENST00000286827, ENST00000541036, ENST00000469412, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: AFG3L2 [Title/Abstract] AND TIAM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TIAM1 | GO:0008284 | positive regulation of cell proliferation | 25032858 |
Tgene | TIAM1 | GO:0010717 | regulation of epithelial to mesenchymal transition | 20826792 |
Tgene | TIAM1 | GO:0030335 | positive regulation of cell migration | 25032858 |
Tgene | TIAM1 | GO:0032092 | positive regulation of protein binding | 23109420 |
Tgene | TIAM1 | GO:0090630 | activation of GTPase activity | 23109420 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-O1-A52J-01A | AFG3L2 | chr18 | 12337340 | - | TIAM1 | chr21 | 32503266 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000269143 | ENST00000286827 | AFG3L2 | chr18 | 12337340 | - | TIAM1 | chr21 | 32503266 | - |
Frame-shift | ENST00000269143 | ENST00000541036 | AFG3L2 | chr18 | 12337340 | - | TIAM1 | chr21 | 32503266 | - |
5CDS-intron | ENST00000269143 | ENST00000469412 | AFG3L2 | chr18 | 12337340 | - | TIAM1 | chr21 | 32503266 | - |
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FusionProtFeatures for AFG3L2_TIAM1 |
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Hgene | Tgene |
AFG3L2 | TIAM1 |
ATP-dependent protease which is essential for axonal andneuron development. In neurons, mediates degradation of SMDT1/EMREbefore its assembly with the uniporter complex, limiting theavailability of SMDT1/EMRE for MCU assembly and promotingefficient assembly of gatekeeper subunits with MCU(PubMed:27642048). Required for the maturation of paraplegin(SPG7) after its cleavage by mitochondrial-processing peptidase(MPP), converting it into a proteolytically active mature form (Bysimilarity). {ECO:0000250|UniProtKB:Q8JZQ2,ECO:0000269|PubMed:27642048}. | Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them.Activates RAC1, CDC42, and to a lesser extent RHOA. Required fornormal cell adhesion and cell migration.{ECO:0000269|PubMed:20361982}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AFG3L2_TIAM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AFG3L2_TIAM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AFG3L2 | PHC2, USP50, BECN1, CLN3, ICT1, MAPK8IP2, RAC2, APP, BTK, HIPK4, FBXO6, CCDC8, SUZ12, RNF2, EGFR, AK2, ATP5F1, CYC1, HSD17B12, NDUFA9, NDUFS1, NDUFS8, SLC25A3, UQCRC2, ATP1A1, ATP5A1, PHB, PHB2, RPN1, TMCO1, UQCRQ, NTRK1, BTRC, MED20, NDUFA11, NDUFA13, TIMMDC1, ELL2, GBA2, TUBA1C, TGS1, NEDD1, RBM45, USF1, NF2, C2orf47, NDUFA4, COQ9, C15orf48, CISD3, OCIAD1, PTPMT1, CCDC58, COQ2, CHCHD2, PDP2, INTU, CYLD, TRIM25 | TIAM1 | PPP1R9B, MAPK8IP2, MAPK8IP1, RAC1, HRAS, MYC, CD44, PRKCA, PRKCB, PRKCG, PRKCE, PRKCD, PRKCZ, ANK1, ANK3, NME1, YWHAG, WHSC1, UBC, ALB, YWHAE, CFTR, BTRC, CSNK1A1, CSNK1E, FBXW11, DARS, KBTBD6, KBTBD7, CTDSPL, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, CGN, RTKN, MAST3, LIMA1, MAGI1, PPM1H, TESK2, DCLK1, ZNF638, DENND4C, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, HDAC4, MAPKAP1, NF1, FAM110B, USP21, CBY1, ANKRD34A, FAM53C, NADK, CDC25C, FAM110A, CAMSAP2, KIAA1804, RASAL2, GIGYF2, PHLDB2, PLEKHA7, KIF1C, INPP5E |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AFG3L2_TIAM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AFG3L2_TIAM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AFG3L2 | C1853249 | SPINOCEREBELLAR ATAXIA 28 | 5 | CTD_human;ORPHANET;UNIPROT |
Hgene | AFG3L2 | C0087012 | Ataxia, Spinocerebellar | 1 | CTD_human |
Hgene | AFG3L2 | C0751778 | Myoclonic Epilepsies, Progressive | 1 | CTD_human;HPO |
Hgene | AFG3L2 | C3280977 | SPASTIC ATAXIA 5, AUTOSOMAL RECESSIVE | 1 | ORPHANET;UNIPROT |
Tgene | TIAM1 | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |