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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 10318

FusionGeneSummary for DNM2_MRPL4

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2_MRPL4
Fusion gene ID: 10318
HgeneTgene
Gene symbol

DNM2

MRPL4

Gene ID

1785

51073

Gene namedynamin 2mitochondrial ribosomal protein L4
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5CGI-28|L4mt
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin II39S ribosomal protein L4, mitochondrialMRP-L4mitochondrial large ribosomal subunit protein uL4m
Modification date2018052720180523
UniProtAcc

P50570

Q9BYD3

Ensembl transtripts involved in fusion geneENST00000585892, ENST00000314646, 
ENST00000359692, ENST00000389253, 
ENST00000355667, ENST00000408974, 
ENST00000591819, 		ENST00000307422, 
ENST00000253099, ENST00000590669, 
ENST00000393733, ENST00000588502, 
Fusion gene scores* DoF score27 X 13 X 12=42123 X 3 X 3=27
# samples 313
** MAII scorelog2(31/4212*10)=-3.76416531575148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNM2 [Title/Abstract] AND MRPL4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N9-A4PZ-01ADNM2chr19

10829079

+MRPL4chr19

10363073

+
TCGALDUCSTCGA-N9-A4PZ-01ADNM2chr19

10829079

+MRPL4chr19

10362822

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000585892ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000585892ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000585892ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000585892ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10363073

+
In-frameENST00000585892ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000314646ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000314646ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000314646ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000314646ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10363073

+
In-frameENST00000314646ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000359692ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000359692ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000359692ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000359692ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10363073

+
In-frameENST00000359692ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000389253ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000389253ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000389253ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000389253ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10363073

+
In-frameENST00000389253ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000355667ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000355667ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000355667ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000355667ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10363073

+
In-frameENST00000355667ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000408974ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000408974ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000408974ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10363073

+
Frame-shiftENST00000408974ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10363073

+
In-frameENST00000408974ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10363073

+
intron-3CDSENST00000591819ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10363073

+
intron-3CDSENST00000591819ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10363073

+
intron-3CDSENST00000591819ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10363073

+
intron-3CDSENST00000591819ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10363073

+
intron-3CDSENST00000591819ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10363073

+
5CDS-5UTRENST00000585892ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000585892ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000585892ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000585892ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000585892ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000314646ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000314646ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000314646ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000314646ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000314646ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000359692ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000359692ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000359692ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000359692ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000359692ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000389253ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000389253ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000389253ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000389253ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000389253ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000355667ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000355667ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000355667ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000355667ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000355667ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000408974ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000408974ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-5UTRENST00000408974ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000408974ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10362822

+
5CDS-intronENST00000408974ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10362822

+
intron-5UTRENST00000591819ENST00000307422DNM2chr19

10829079

+MRPL4chr19

10362822

+
intron-5UTRENST00000591819ENST00000253099DNM2chr19

10829079

+MRPL4chr19

10362822

+
intron-5UTRENST00000591819ENST00000590669DNM2chr19

10829079

+MRPL4chr19

10362822

+
intron-intronENST00000591819ENST00000393733DNM2chr19

10829079

+MRPL4chr19

10362822

+
intron-intronENST00000591819ENST00000588502DNM2chr19

10829079

+MRPL4chr19

10362822

+

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FusionProtFeatures for DNM2_MRPL4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM2

P50570

MRPL4

Q9BYD3

Microtubule-associated force-producing protein involvedin producing microtubule bundles and able to bind and hydrolyzeGTP. Plays a role in the regulation of neuron morphology, axongrowth and formation of neuronal growth cones (By similarity).Plays an important role in vesicular trafficking processes, inparticular endocytosis. Involved in cytokinesis (PubMed:12498685).Regulates maturation of apoptotic cell corpse-containingphagosomes by recruiting PIK3C3 to the phagosome membrane (Bysimilarity). {ECO:0000250|UniProtKB:P39052,ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DNM2_MRPL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DNM2_ENST00000585892_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_297aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRGAGLASAYRQPGEARGWRRGRRMKFGGVQGSSLTFA
QPLQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKN
FKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLEL

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_297aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRGAGLASAYRQPGEARGWRRGRRMKFGGVQGSSLTFA
QPLQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKN
FKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLEL

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_297aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRGAGLASAYRQPGEARGWRRGRRMKFGGVQGSSLTFA
QPLQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKN
FKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLEL

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_297aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRGAGLASAYRQPGEARGWRRGRRMKFGGVQGSSLTFA
QPLQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKN
FKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLEL

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_297aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRGAGLASAYRQPGEARGWRRGRRMKFGGVQGSSLTFA
QPLQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKN
FKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLEL

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_297aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRGAGLASAYRQPGEARGWRRGRRMKFGGVQGSSLTFA
QPLQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKN
FKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLEL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DNM2_ENST00000585892_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_891nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGGCGCGGGCCTGGCTTCG
GCCTACCGGCAGCCAGGTGAGGCCAGGGGCTGGAGGCGTGGTCGAAGGATGAAATTTGGGGGTGTCCAGGGGTCGTCTCTCACTTTCGCC
CAACCCTTGCAGGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAG
CCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAG
CGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAAC
TTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGG
GCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTG
CCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTG

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_891nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGGCGCGGGCCTGGCTTCG
GCCTACCGGCAGCCAGGTGAGGCCAGGGGCTGGAGGCGTGGTCGAAGGATGAAATTTGGGGGTGTCCAGGGGTCGTCTCTCACTTTCGCC
CAACCCTTGCAGGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAG
CCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAG
CGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAAC
TTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGG
GCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTG
CCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTG

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_891nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGGCGCGGGCCTGGCTTCG
GCCTACCGGCAGCCAGGTGAGGCCAGGGGCTGGAGGCGTGGTCGAAGGATGAAATTTGGGGGTGTCCAGGGGTCGTCTCTCACTTTCGCC
CAACCCTTGCAGGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAG
CCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAG
CGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAAC
TTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGG
GCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTG
CCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTG

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_891nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGGCGCGGGCCTGGCTTCG
GCCTACCGGCAGCCAGGTGAGGCCAGGGGCTGGAGGCGTGGTCGAAGGATGAAATTTGGGGGTGTCCAGGGGTCGTCTCTCACTTTCGCC
CAACCCTTGCAGGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAG
CCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAG
CGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAAC
TTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGG
GCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTG
CCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTG

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_891nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGGCGCGGGCCTGGCTTCG
GCCTACCGGCAGCCAGGTGAGGCCAGGGGCTGGAGGCGTGGTCGAAGGATGAAATTTGGGGGTGTCCAGGGGTCGTCTCTCACTTTCGCC
CAACCCTTGCAGGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAG
CCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAG
CGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAAC
TTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGG
GCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTG
CCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTG

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_891nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGGCGCGGGCCTGGCTTCG
GCCTACCGGCAGCCAGGTGAGGCCAGGGGCTGGAGGCGTGGTCGAAGGATGAAATTTGGGGGTGTCCAGGGGTCGTCTCTCACTTTCGCC
CAACCCTTGCAGGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAG
CCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAG
CGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAAC
TTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGG
GCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTG
CCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_DNM2_ENST00000585892_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_1030nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCG
ACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAGCCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCA
GTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAGCGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCC
AGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAACTTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGG
GGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGGGCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTT
GCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTGCCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAG
CTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTGCCCACCGGAGACCCACAGTACCTGACAGAGCTGGCGCACTACCGCCGC
TGGGGGGACTCCGTACTCCTCGTGGACTTGTGAGGGCACAGGGCAGAGCAGGGGCAGGGGGCCCTGAGCTCCGTACTCTGAGGGTTCAAC

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_1030nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCG
ACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAGCCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCA
GTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAGCGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCC
AGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAACTTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGG
GGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGGGCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTT
GCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTGCCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAG
CTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTGCCCACCGGAGACCCACAGTACCTGACAGAGCTGGCGCACTACCGCCGC
TGGGGGGACTCCGTACTCCTCGTGGACTTGTGAGGGCACAGGGCAGAGCAGGGGCAGGGGGCCCTGAGCTCCGTACTCTGAGGGTTCAAC

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_1016nt
GCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGT
CGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATC
CCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGA
GCAGGTGGCGAGCGAGGGTCTCCCGGAGCCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGT
CGAGTCCTTGCGGGGCTTCGAGCAGGAGCGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACT
GCACCAGGTTGCTATGTGGCAGAAGAACTTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAA
GCCTTGGCCGCAGAAAGGCACTGGGCGGGCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCG
GGGCCCCACAAGTTACTACTACATGCTGCCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGA
CCTGCACATCATGGACTCCCTAGAGCTGCCCACCGGAGACCCACAGTACCTGACAGAGCTGGCGCACTACCGCCGCTGGGGGGACTCCGT
ACTCCTCGTGGACTTGTGAGGGCACAGGGCAGAGCAGGGGCAGGGGGCCCTGAGCTCCGTACTCTGAGGGTTCAACCCCCACTCCCTGGC

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_978nt
CCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCT
CGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCAT
CGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGG
CCGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAGCCCGTGCTGC
GCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAGCGCGTGGGCC
TGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAACTTCAAGAGAA
TTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGGGCCCGGCATG
GCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTGCCCATGAAGG
TGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTGCCCACCGGAG
ACCCACAGTACCTGACAGAGCTGGCGCACTACCGCCGCTGGGGGGACTCCGTACTCCTCGTGGACTTGTGAGGGCACAGGGCAGAGCAGG

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_946nt
CAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACC
GCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGA
TCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGCCTGAGTTCCCTGGCGGAAGAGGCAGCG
CGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAGCCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGA
CGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAGCGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACC
GCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAACTTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAG
GTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGGGCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGA
GGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTGCCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACC
GTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTGCCCACCGGAGACCCACAGTACCTGACAGAGCTGGCGCACTAC
CGCCGCTGGGGGGACTCCGTACTCCTCGTGGACTTGTGAGGGCACAGGGCAGAGCAGGGGCAGGGGGCCCTGAGCTCCGTACTCTGAGGG

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_MRPL4_ENST00000588502_chr19_10363073_+_901nt
AGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACG
CCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGG
AGAACTTCGTGGGCCGGCCTGAGTTCCCTGGCGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCG
GAGCCCGTGCTGCGCAAAGTCGAGCTCCCGGTACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAG
GAGCGCGTGGGCCTGGCCGACCTGCACCCCGATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAG
AACTTCAAGAGAATTAGCTATGCCAAGACCAAGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGG
CGGGCCCGGCATGGCAGCATCCGCTCTCCGCTCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATG
CTGCCCATGAAGGTGCGGGCGCTGGGTCTCAAAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAG
CTGCCCACCGGAGACCCACAGTACCTGACAGAGCTGGCGCACTACCGCCGCTGGGGGGACTCCGTACTCCTCGTGGACTTGTGAGGGCAC
AGGGCAGAGCAGGGGCAGGGGGCCCTGAGCTCCGTACTCTGAGGGTTCAACCCCCACTCCCTGGCCTCTCTTACAGAACACACGAGGAGA


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FusionGenePPI for DNM2_MRPL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNM2SHANK1, SHANK2, SNX9, PDE6G, DDX39B, FER, EPS15, RUVBL2, MEPCE, RPAP2, GTF2E2, PACSIN1, PACSIN2, PACSIN3, TRIP10, PSTPIP1, FCHSD1, WIPI2, HMGB1, DNM1, RPS2, ATXN3, ZBTB16, MAN1B1, CCT7, RWDD2B, CCDC90B, DYNC1I1, TYK2, TIAM2, ITSN1, GDF9, SPRY2, ITSN2, SIRT7, SH3KBP1, CD2AP, AMPH, SH3GL2, SRC, GRB2, SHC1, APP, PICALM, RBMS1, SLC30A5, CTTN, FN1, VCAM1, PEX14, MANEA, KCNN3, ITGA4, AHI1, MPP6, FBXO6, FNBP1L, FNBP1, WBP4, EGFR, STAU1, DNM3, SCN2B, LYPD6, HTR6, BIN1, GBE1, GGA1, PTPN13, RPE, RTCB, NTRK1, OFD1, FGFR1OP, CNTRL, FBF1, NPHP1, DCTN1, RPGR, TCTN1, XRCC6, HNRNPD, PLK1, PML, BUB3, RHOU, SNW1, CDC5L, PTPN11, PIK3R1, PDGFRA, SNX18, GYPB, TMEM9B, TBC1D15, ZBBX, RBM3, DNALI1, TRIM25, TESMRPL4KRTAP4-12, EIF2B1, ICT1, CUL3, CAND1, MRPL3, MRPL15, MRPL24, MRPL2, MRPL46, MRPL14, MRPL23, MRPL1, TUFM, ILF3, HNRNPR, CYC1, CD55, RPS18, CSNK2A1, C1QBP, SOX2, EXOSC6, XRN2, GRSF1, TRIM23, CLK2, BTRC, FBXW11, MRPL43, MRPL28, HSPD1, YARS2, AMER1, UBR5, MTERF3, NGRN, WDR26, PTCD1, ZSWIM8, MRPL45, FAM83H, TRUB2, MRPL9, ARMC8, MRPL32, MRPL11, DDX28, MRPL48, MRPL40, MAEA, MKLN1, MRPL39, RMND5A, RMND5B, MRPL41, GLS, FASTKD2, RANBP9, RANBP10, CINP, MRPL22, SPATA5L1, MRPL37, PDPR, MRPL10, MRPL49, MRPL44, MRPL50, MRPL38, MRPL20, HTRA2, RPUSD4, GID4, MRPL27, MRPL55, NEFL, MALSU1, MRPL47, MRPL16, MRPS30, GTPBP6, GID8, MRPS18A, MRPL19, TCF25, HNRNPA1, ZMYND19, MSI2, TATDN2, MRPL21, MRPL13, MRPL17, YPEL5, MCAT, MRPL33, GADD45GIP1, MRPL35, POLG, MRPL30, MRPL42, CSNK1E, MRPL51, RNMTL1, MRPL18, AARS2, MRPL53, RPUSD3, MRPL57, MRPL34, MARS2, MRPL52, SAV1, RPL17, RPL8, RPS2, PCNA, L1TD1, ACKR3, DUSP11, GNPNAT1, LONP1, MRPL12, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNM2_MRPL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNM2_MRPL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant9CTD_human;ORPHANET;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)4CTD_human;ORPHANET;UNIPROT
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 51ORPHANET;UNIPROT