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Fusion gene ID: 10308 |
FusionGeneSummary for DNM2_ARHGEF7 |
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Fusion gene information | Fusion gene name: DNM2_ARHGEF7 | Fusion gene ID: 10308 | Hgene | Tgene | Gene symbol | DNM2 | ARHGEF7 | Gene ID | 1785 | 8874 |
Gene name | dynamin 2 | Rho guanine nucleotide exchange factor 7 | |
Synonyms | CMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5 | BETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB | |
Cytomap | 19p13.2 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | dynamin-2dynamin II | rho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | P50570 | Q14155 | |
Ensembl transtripts involved in fusion gene | ENST00000585892, ENST00000314646, ENST00000359692, ENST00000389253, ENST00000355667, ENST00000408974, ENST00000591819, | ENST00000317133, ENST00000375741, ENST00000375739, ENST00000370623, ENST00000544132, ENST00000218789, ENST00000375736, ENST00000426073, ENST00000375737, ENST00000375723, ENST00000478679, ENST00000483189, | |
Fusion gene scores | * DoF score | 27 X 13 X 12=4212 | 6 X 7 X 4=168 |
# samples | 31 | 7 | |
** MAII score | log2(31/4212*10)=-3.76416531575148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNM2 [Title/Abstract] AND ARHGEF7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DNM2 | GO:1903526 | negative regulation of membrane tubulation | 18388313 |
Tgene | ARHGEF7 | GO:0043547 | positive regulation of GTPase activity | 21048939 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-SI-A71O-06A | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000585892 | ENST00000317133 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000375741 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000375739 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000370623 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000544132 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000218789 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000375736 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000426073 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000375737 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000375723 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000478679 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000585892 | ENST00000483189 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000317133 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000375741 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000375739 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000370623 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000544132 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000218789 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000375736 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000426073 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000375737 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000375723 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000478679 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000314646 | ENST00000483189 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000317133 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000375741 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000375739 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000370623 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000544132 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000218789 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000375736 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000426073 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000375737 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000375723 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000478679 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000359692 | ENST00000483189 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000317133 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000375741 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000375739 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000370623 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000544132 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000218789 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000375736 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000426073 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000375737 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000375723 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000478679 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000389253 | ENST00000483189 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000317133 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000375741 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000375739 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000370623 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000544132 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000218789 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000375736 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000426073 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000375737 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000375723 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000478679 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000355667 | ENST00000483189 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000317133 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000375741 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000375739 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000370623 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000544132 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000218789 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000375736 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000426073 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000375737 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000375723 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000478679 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
5CDS-intron | ENST00000408974 | ENST00000483189 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000317133 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000375741 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000375739 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000370623 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000544132 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000218789 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000375736 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000426073 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000375737 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000375723 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000478679 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
intron-intron | ENST00000591819 | ENST00000483189 | DNM2 | chr19 | 10930765 | + | ARHGEF7 | chr13 | 111953095 | + |
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FusionProtFeatures for DNM2_ARHGEF7 |
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Hgene | Tgene |
DNM2 | ARHGEF7 |
Microtubule-associated force-producing protein involvedin producing microtubule bundles and able to bind and hydrolyzeGTP. Plays a role in the regulation of neuron morphology, axongrowth and formation of neuronal growth cones (By similarity).Plays an important role in vesicular trafficking processes, inparticular endocytosis. Involved in cytokinesis (PubMed:12498685).Regulates maturation of apoptotic cell corpse-containingphagosomes by recruiting PIK3C3 to the phagosome membrane (Bysimilarity). {ECO:0000250|UniProtKB:P39052,ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNM2_ARHGEF7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNM2_ARHGEF7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DNM2 | SHANK1, SHANK2, SNX9, PDE6G, DDX39B, FER, EPS15, RUVBL2, MEPCE, RPAP2, GTF2E2, PACSIN1, PACSIN2, PACSIN3, TRIP10, PSTPIP1, FCHSD1, WIPI2, HMGB1, DNM1, RPS2, ATXN3, ZBTB16, MAN1B1, CCT7, RWDD2B, CCDC90B, DYNC1I1, TYK2, TIAM2, ITSN1, GDF9, SPRY2, ITSN2, SIRT7, SH3KBP1, CD2AP, AMPH, SH3GL2, SRC, GRB2, SHC1, APP, PICALM, RBMS1, SLC30A5, CTTN, FN1, VCAM1, PEX14, MANEA, KCNN3, ITGA4, AHI1, MPP6, FBXO6, FNBP1L, FNBP1, WBP4, EGFR, STAU1, DNM3, SCN2B, LYPD6, HTR6, BIN1, GBE1, GGA1, PTPN13, RPE, RTCB, NTRK1, OFD1, FGFR1OP, CNTRL, FBF1, NPHP1, DCTN1, RPGR, TCTN1, XRCC6, HNRNPD, PLK1, PML, BUB3, RHOU, SNW1, CDC5L, PTPN11, PIK3R1, PDGFRA, SNX18, GYPB, TMEM9B, TBC1D15, ZBBX, RBM3, DNALI1, TRIM25, TES | ARHGEF7 | SHANK2, SHANK1, CBL, SHANK3, TUBB3, GIT1, PPM1E, PPM1F, PAK1, PAK3, CDC42, CBLB, CALM1, ITCH, LRRK2, PAK2, ADAM15, ARHGEF6, GRB2, ERBB2IP, MEOX2, EGFR, RAC1, NCK2, HSPB1, KDM2A, NTRK1, MED4, SLC33A1, SCRIB, GIT2, FBXO28, LPXN, NCKIPSD, ICAM1, EXOC1, KLHL2, CAMK4, SYNC, C1orf106, POTEB3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNM2_ARHGEF7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNM2_ARHGEF7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DNM2 | C1834558 | Myopathy, Centronuclear, Autosomal Dominant | 9 | CTD_human;ORPHANET;UNIPROT |
Hgene | DNM2 | C1847902 | CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder) | 4 | CTD_human;ORPHANET;UNIPROT |
Hgene | DNM2 | C0752282 | Congenital Structural Myopathy | 1 | CTD_human |
Hgene | DNM2 | C3809272 | LETHAL CONGENITAL CONTRACTURE SYNDROME 5 | 1 | ORPHANET;UNIPROT |