FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10308

FusionGeneSummary for DNM2_ARHGEF7

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2_ARHGEF7
Fusion gene ID: 10308
HgeneTgene
Gene symbol

DNM2

ARHGEF7

Gene ID

1785

8874

Gene namedynamin 2Rho guanine nucleotide exchange factor 7
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5BETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB
Cytomap

19p13.2

13q34

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIrho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein
Modification date2018052720180522
UniProtAcc

P50570

Q14155

Ensembl transtripts involved in fusion geneENST00000585892, ENST00000314646, 
ENST00000359692, ENST00000389253, 
ENST00000355667, ENST00000408974, 
ENST00000591819, 
ENST00000317133, 
ENST00000375741, ENST00000375739, 
ENST00000370623, ENST00000544132, 
ENST00000218789, ENST00000375736, 
ENST00000426073, ENST00000375737, 
ENST00000375723, ENST00000478679, 
ENST00000483189, 
Fusion gene scores* DoF score27 X 13 X 12=42126 X 7 X 4=168
# samples 317
** MAII scorelog2(31/4212*10)=-3.76416531575148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM2 [Title/Abstract] AND ARHGEF7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneARHGEF7

GO:0043547

positive regulation of GTPase activity

21048939


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-SI-A71O-06ADNM2chr19

10930765

+ARHGEF7chr13

111953095

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000585892ENST00000317133DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000375741DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000375739DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000370623DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000544132DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000218789DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000375736DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000426073DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000375737DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000375723DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000478679DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000585892ENST00000483189DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000317133DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000375741DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000375739DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000370623DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000544132DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000218789DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000375736DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000426073DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000375737DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000375723DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000478679DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000314646ENST00000483189DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000317133DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000375741DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000375739DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000370623DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000544132DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000218789DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000375736DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000426073DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000375737DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000375723DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000478679DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000359692ENST00000483189DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000317133DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000375741DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000375739DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000370623DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000544132DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000218789DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000375736DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000426073DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000375737DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000375723DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000478679DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000389253ENST00000483189DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000317133DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000375741DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000375739DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000370623DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000544132DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000218789DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000375736DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000426073DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000375737DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000375723DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000478679DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000355667ENST00000483189DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000317133DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000375741DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000375739DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000370623DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000544132DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000218789DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000375736DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000426073DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000375737DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000375723DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000478679DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
5CDS-intronENST00000408974ENST00000483189DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000317133DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000375741DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000375739DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000370623DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000544132DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000218789DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000375736DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000426073DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000375737DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000375723DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000478679DNM2chr19

10930765

+ARHGEF7chr13

111953095

+
intron-intronENST00000591819ENST00000483189DNM2chr19

10930765

+ARHGEF7chr13

111953095

+

Top

FusionProtFeatures for DNM2_ARHGEF7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM2

P50570

ARHGEF7

Q14155

Microtubule-associated force-producing protein involvedin producing microtubule bundles and able to bind and hydrolyzeGTP. Plays a role in the regulation of neuron morphology, axongrowth and formation of neuronal growth cones (By similarity).Plays an important role in vesicular trafficking processes, inparticular endocytosis. Involved in cytokinesis (PubMed:12498685).Regulates maturation of apoptotic cell corpse-containingphagosomes by recruiting PIK3C3 to the phagosome membrane (Bysimilarity). {ECO:0000250|UniProtKB:P39052,ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DNM2_ARHGEF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DNM2_ARHGEF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNM2SHANK1, SHANK2, SNX9, PDE6G, DDX39B, FER, EPS15, RUVBL2, MEPCE, RPAP2, GTF2E2, PACSIN1, PACSIN2, PACSIN3, TRIP10, PSTPIP1, FCHSD1, WIPI2, HMGB1, DNM1, RPS2, ATXN3, ZBTB16, MAN1B1, CCT7, RWDD2B, CCDC90B, DYNC1I1, TYK2, TIAM2, ITSN1, GDF9, SPRY2, ITSN2, SIRT7, SH3KBP1, CD2AP, AMPH, SH3GL2, SRC, GRB2, SHC1, APP, PICALM, RBMS1, SLC30A5, CTTN, FN1, VCAM1, PEX14, MANEA, KCNN3, ITGA4, AHI1, MPP6, FBXO6, FNBP1L, FNBP1, WBP4, EGFR, STAU1, DNM3, SCN2B, LYPD6, HTR6, BIN1, GBE1, GGA1, PTPN13, RPE, RTCB, NTRK1, OFD1, FGFR1OP, CNTRL, FBF1, NPHP1, DCTN1, RPGR, TCTN1, XRCC6, HNRNPD, PLK1, PML, BUB3, RHOU, SNW1, CDC5L, PTPN11, PIK3R1, PDGFRA, SNX18, GYPB, TMEM9B, TBC1D15, ZBBX, RBM3, DNALI1, TRIM25, TESARHGEF7SHANK2, SHANK1, CBL, SHANK3, TUBB3, GIT1, PPM1E, PPM1F, PAK1, PAK3, CDC42, CBLB, CALM1, ITCH, LRRK2, PAK2, ADAM15, ARHGEF6, GRB2, ERBB2IP, MEOX2, EGFR, RAC1, NCK2, HSPB1, KDM2A, NTRK1, MED4, SLC33A1, SCRIB, GIT2, FBXO28, LPXN, NCKIPSD, ICAM1, EXOC1, KLHL2, CAMK4, SYNC, C1orf106, POTEB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DNM2_ARHGEF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DNM2_ARHGEF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant9CTD_human;ORPHANET;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)4CTD_human;ORPHANET;UNIPROT
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 51ORPHANET;UNIPROT