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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10307

FusionGeneSummary for DNM2_ARHGAP25

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2_ARHGAP25
Fusion gene ID: 10307
HgeneTgene
Gene symbol

DNM2

ARHGAP25

Gene ID

1785

9938

Gene namedynamin 2Rho GTPase activating protein 25
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5HEL-S-308|KAIA0053
Cytomap

19p13.2

2p13.3

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIrho GTPase-activating protein 25epididymis secretory protein Li 308rho-type GTPase-activating protein 25
Modification date2018052720180519
UniProtAcc

P50570

P42331

Ensembl transtripts involved in fusion geneENST00000585892, ENST00000314646, 
ENST00000359692, ENST00000389253, 
ENST00000355667, ENST00000408974, 
ENST00000591819, 		ENST00000544262, 
ENST00000295381, ENST00000409202, 
ENST00000456116, ENST00000467265, 
ENST00000409030, ENST00000409220, 
ENST00000497079, ENST00000479844, 
Fusion gene scores* DoF score27 X 13 X 12=42123 X 2 X 3=18
# samples 313
** MAII scorelog2(31/4212*10)=-3.76416531575148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNM2 [Title/Abstract] AND ARHGAP25 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-ZF-AA51-01ADNM2chr19

10829079

+ARHGAP25chr2

69002353

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000585892ENST00000544262DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000585892ENST00000295381DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000585892ENST00000409202DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000585892ENST00000456116DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000585892ENST00000467265DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000585892ENST00000409030DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000585892ENST00000409220DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000585892ENST00000497079DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-intronENST00000585892ENST00000479844DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000314646ENST00000544262DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000314646ENST00000295381DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000314646ENST00000409202DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000314646ENST00000456116DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000314646ENST00000467265DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000314646ENST00000409030DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000314646ENST00000409220DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000314646ENST00000497079DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-intronENST00000314646ENST00000479844DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000359692ENST00000544262DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000359692ENST00000295381DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000359692ENST00000409202DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000359692ENST00000456116DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000359692ENST00000467265DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000359692ENST00000409030DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000359692ENST00000409220DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000359692ENST00000497079DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-intronENST00000359692ENST00000479844DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000389253ENST00000544262DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000389253ENST00000295381DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000389253ENST00000409202DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000389253ENST00000456116DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000389253ENST00000467265DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000389253ENST00000409030DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000389253ENST00000409220DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000389253ENST00000497079DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-intronENST00000389253ENST00000479844DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000355667ENST00000544262DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000355667ENST00000295381DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000355667ENST00000409202DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000355667ENST00000456116DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000355667ENST00000467265DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000355667ENST00000409030DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000355667ENST00000409220DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000355667ENST00000497079DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-intronENST00000355667ENST00000479844DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000408974ENST00000544262DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000408974ENST00000295381DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000408974ENST00000409202DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000408974ENST00000456116DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000408974ENST00000467265DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000408974ENST00000409030DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000408974ENST00000409220DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000408974ENST00000497079DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
5CDS-intronENST00000408974ENST00000479844DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-5UTRENST00000591819ENST00000544262DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-5UTRENST00000591819ENST00000295381DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-5UTRENST00000591819ENST00000409202DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-3UTRENST00000591819ENST00000456116DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-3UTRENST00000591819ENST00000467265DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-3UTRENST00000591819ENST00000409030DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-3UTRENST00000591819ENST00000409220DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-3UTRENST00000591819ENST00000497079DNM2chr19

10829079

+ARHGAP25chr2

69002353

+
intron-intronENST00000591819ENST00000479844DNM2chr19

10829079

+ARHGAP25chr2

69002353

+

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FusionProtFeatures for DNM2_ARHGAP25


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM2

P50570

ARHGAP25

P42331

Microtubule-associated force-producing protein involvedin producing microtubule bundles and able to bind and hydrolyzeGTP. Plays a role in the regulation of neuron morphology, axongrowth and formation of neuronal growth cones (By similarity).Plays an important role in vesicular trafficking processes, inparticular endocytosis. Involved in cytokinesis (PubMed:12498685).Regulates maturation of apoptotic cell corpse-containingphagosomes by recruiting PIK3C3 to the phagosome membrane (Bysimilarity). {ECO:0000250|UniProtKB:P39052,ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}. GTPase activator for the Rho-type GTPases by convertingthem to an inactive GDP-bound state. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNM2_ARHGAP25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNM2_ARHGAP25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNM2SHANK1, SHANK2, SNX9, PDE6G, DDX39B, FER, EPS15, RUVBL2, MEPCE, RPAP2, GTF2E2, PACSIN1, PACSIN2, PACSIN3, TRIP10, PSTPIP1, FCHSD1, WIPI2, HMGB1, DNM1, RPS2, ATXN3, ZBTB16, MAN1B1, CCT7, RWDD2B, CCDC90B, DYNC1I1, TYK2, TIAM2, ITSN1, GDF9, SPRY2, ITSN2, SIRT7, SH3KBP1, CD2AP, AMPH, SH3GL2, SRC, GRB2, SHC1, APP, PICALM, RBMS1, SLC30A5, CTTN, FN1, VCAM1, PEX14, MANEA, KCNN3, ITGA4, AHI1, MPP6, FBXO6, FNBP1L, FNBP1, WBP4, EGFR, STAU1, DNM3, SCN2B, LYPD6, HTR6, BIN1, GBE1, GGA1, PTPN13, RPE, RTCB, NTRK1, OFD1, FGFR1OP, CNTRL, FBF1, NPHP1, DCTN1, RPGR, TCTN1, XRCC6, HNRNPD, PLK1, PML, BUB3, RHOU, SNW1, CDC5L, PTPN11, PIK3R1, PDGFRA, SNX18, GYPB, TMEM9B, TBC1D15, ZBBX, RBM3, DNALI1, TRIM25, TESARHGAP25DMWD, DYNC2H1, DSTYK, GTF2H2, POLD1, SEC23IP, DPYSL4, ACACA, TBL3, CAMK2D, CAMK2G, UBA6, DDX11L8, MSTO1, ATG7, DPP9, PER1, HERC3, ANGEL1, VWA9, RECQL4, THUMPD3, C2orf44, KDM5C, NPRL3, TRIM27, AP5B1, TRIM65, WRAP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNM2_ARHGAP25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNM2_ARHGAP25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant9CTD_human;ORPHANET;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)4CTD_human;ORPHANET;UNIPROT
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 51ORPHANET;UNIPROT