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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 10306

FusionGeneSummary for DNM2_ANGPTL4

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2_ANGPTL4
Fusion gene ID: 10306
HgeneTgene
Gene symbol

DNM2

ANGPTL4

Gene ID

1785

51129

Gene namedynamin 2angiopoietin like 4
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5ARP4|FIAF|HARP|HFARP|NL2|PGAR|TGQTL|UNQ171|pp1158
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIangiopoietin-related protein 4PPARG angiopoietin related proteinfasting-induced adipose factorhepatic angiopoietin-related proteinhepatic fibrinogen/angiopoietin-related proteinperoxisome proliferator-activated receptor (PPAR) gamma induced angiopoie
Modification date2018052720180519
UniProtAcc

P50570

Q9BY76

Ensembl transtripts involved in fusion geneENST00000585892, ENST00000314646, 
ENST00000359692, ENST00000389253, 
ENST00000355667, ENST00000408974, 
ENST00000591819, 		ENST00000301455, 
ENST00000541807, ENST00000393962, 
Fusion gene scores* DoF score27 X 13 X 12=42124 X 3 X 3=36
# samples 314
** MAII scorelog2(31/4212*10)=-3.76416531575148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNM2 [Title/Abstract] AND ANGPTL4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneANGPTL4

GO:0043066

negative regulation of apoptotic process

10698685

TgeneANGPTL4

GO:0051005

negative regulation of lipoprotein lipase activity

19542565


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-KR-A7K8-01ADNM2chr19

10829079

+ANGPTL4chr19

8438589

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000585892ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000585892ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000585892ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000314646ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000314646ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000314646ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000359692ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000359692ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000359692ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000389253ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000389253ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000389253ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000355667ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000355667ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000355667ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000408974ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000408974ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000408974ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
intron-3CDSENST00000591819ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
intron-3CDSENST00000591819ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
intron-3CDSENST00000591819ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+

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FusionProtFeatures for DNM2_ANGPTL4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM2

P50570

ANGPTL4

Q9BY76

Microtubule-associated force-producing protein involvedin producing microtubule bundles and able to bind and hydrolyzeGTP. Plays a role in the regulation of neuron morphology, axongrowth and formation of neuronal growth cones (By similarity).Plays an important role in vesicular trafficking processes, inparticular endocytosis. Involved in cytokinesis (PubMed:12498685).Regulates maturation of apoptotic cell corpse-containingphagosomes by recruiting PIK3C3 to the phagosome membrane (Bysimilarity). {ECO:0000250|UniProtKB:P39052,ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12138_4653871Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12038_4653867Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12138_4653871Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12038_4653867Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12138_4653870Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12138_4553871RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12038_4553867RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12138_4553871RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12038_4553867RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12138_4553870RegionG1 motif

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121747_86653871Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120747_86653867Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121747_86653871Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120747_86653867Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121747_86653870Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12128_29453871DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121519_62553871DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121653_74453871DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12028_29453867DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120519_62553867DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120653_74453867DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12128_29453871DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121519_62553871DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121653_74453871DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12028_29453867DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120519_62553867DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120653_74453867DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12128_29453870DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121519_62553870DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121653_74453870DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121205_21153871Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121236_23953871Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120205_21153867Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120236_23953867Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121205_21153871Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121236_23953871Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120205_21153867Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120236_23953867Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121205_21153870Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121236_23953870Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121136_13953871RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121205_20853871RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121235_23853871RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12164_6653871RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120136_13953867RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120205_20853867RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120235_23853867RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12064_6653867RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121136_13953871RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121205_20853871RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121235_23853871RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12164_6653871RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120136_13953867RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120205_20853867RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120235_23853867RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12064_6653867RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121136_13953870RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121205_20853870RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121235_23853870RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12164_6653870RegionG2 motif
TgeneANGPTL4chr19:10829079chr19:8438589ENST00000301455+57100_143346407Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:10829079chr19:8438589ENST00000393962+46100_143308369Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:10829079chr19:8438589ENST00000301455+57179_401346407DomainFibrinogen C-terminal
TgeneANGPTL4chr19:10829079chr19:8438589ENST00000393962+46179_401308369DomainFibrinogen C-terminal


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FusionGeneSequence for DNM2_ANGPTL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DNM2_ENST00000585892_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000585892_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_114aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRRLVVWHLQPFQPQRPVLPLHPTAAAEAXEGNLLEDL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DNM2_ENST00000585892_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000585892_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_343nt
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGAC
CTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCAC
CTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_DNM2_ENST00000585892_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_994nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAAC
CTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTAC
CCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA
AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACA
GAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCT
CAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGC
CAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTG
TTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGGAGCTCACAGAGTTCTTGGAATAAAAGCAACCTCAGAAC

>In-frame_DNM2_ENST00000585892_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_952nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAAC
CTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTAC
CCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA
AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACA
GAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCT
CAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGC
CAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTG

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_994nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAAC
CTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTAC
CCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA
AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACA
GAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCT
CAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGC
CAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTG
TTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGGAGCTCACAGAGTTCTTGGAATAAAAGCAACCTCAGAAC

>In-frame_DNM2_ENST00000314646_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_952nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAAC
CTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTAC
CCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA
AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACA
GAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCT
CAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGC
CAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTG

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_980nt
GCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGT
CGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATC
CCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTA
CTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCAC
CACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTT
GGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCAC
GACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGC
GTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAA
TGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCC

>In-frame_DNM2_ENST00000359692_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_938nt
GCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGT
CGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATC
CCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTA
CTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCAC
CACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTT
GGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCAC
GACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGC
GTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAA
TGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCC

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_942nt
CCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCT
CGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCAT
CGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGG
CCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGA
AGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCT
CCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCA
GGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGC
ATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCC
AGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGC
TTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGG

>In-frame_DNM2_ENST00000389253_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_900nt
CCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCT
CGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCAT
CGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGG
CCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGA
AGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCT
CCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCA
GGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGC
ATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCC
AGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGC
TTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGG

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_910nt
CAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACC
GCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGA
TCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCAT
TCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGC
TACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCC
CACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTG
TGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGA
TATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGG
GCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTG
GTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGGAGCTCACAGAGTTCTTGGAATAAAAGCAACCT

>In-frame_DNM2_ENST00000355667_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_868nt
CAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACC
GCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGA
TCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCAT
TCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGC
TACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCC
CACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTG
TGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGA
TATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGG
GCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTG

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_ANGPTL4_ENST00000301455_chr19_8438589_+_865nt
AGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACG
CCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGG
AGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGG
CAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCA
GCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTT
CCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGT
GCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCA
CTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGA
CGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAAT

>In-frame_DNM2_ENST00000408974_chr19_10829079_+_ANGPTL4_ENST00000393962_chr19_8438589_+_823nt
AGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACG
CCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGG
AGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGG
CAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCA
GCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTT
CCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGT
GCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCA
CTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGA
CGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAAT


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FusionGenePPI for DNM2_ANGPTL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNM2SHANK1, SHANK2, SNX9, PDE6G, DDX39B, FER, EPS15, RUVBL2, MEPCE, RPAP2, GTF2E2, PACSIN1, PACSIN2, PACSIN3, TRIP10, PSTPIP1, FCHSD1, WIPI2, HMGB1, DNM1, RPS2, ATXN3, ZBTB16, MAN1B1, CCT7, RWDD2B, CCDC90B, DYNC1I1, TYK2, TIAM2, ITSN1, GDF9, SPRY2, ITSN2, SIRT7, SH3KBP1, CD2AP, AMPH, SH3GL2, SRC, GRB2, SHC1, APP, PICALM, RBMS1, SLC30A5, CTTN, FN1, VCAM1, PEX14, MANEA, KCNN3, ITGA4, AHI1, MPP6, FBXO6, FNBP1L, FNBP1, WBP4, EGFR, STAU1, DNM3, SCN2B, LYPD6, HTR6, BIN1, GBE1, GGA1, PTPN13, RPE, RTCB, NTRK1, OFD1, FGFR1OP, CNTRL, FBF1, NPHP1, DCTN1, RPGR, TCTN1, XRCC6, HNRNPD, PLK1, PML, BUB3, RHOU, SNW1, CDC5L, PTPN11, PIK3R1, PDGFRA, SNX18, GYPB, TMEM9B, TBC1D15, ZBBX, RBM3, DNALI1, TRIM25, TESANGPTL4SMARCA4, ACTB, KAT5, MYC, AURKA, BRMS1, CASP8, CDKN2A, CDKN2C, ESR1, FBXW7, FGFR4, TGFB1, WDR47, NMT2, PM20D2, AASDHPPT, NMT1, ITIH2, ARMC8, DNAJB4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNM2_ANGPTL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNM2_ANGPTL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant9CTD_human;ORPHANET;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)4CTD_human;ORPHANET;UNIPROT
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 51ORPHANET;UNIPROT
TgeneANGPTL4C0024232Lymphatic Metastasis1CTD_human
TgeneANGPTL4C0027626Neoplasm Invasiveness1CTD_human
TgeneANGPTL4C0027627Neoplasm Metastasis1CTD_human
TgeneANGPTL4C0242339Dyslipidemias1CTD_human
TgeneANGPTL4C1458155Mammary Neoplasms1CTD_human
TgeneANGPTL4C1956346Coronary Artery Disease1CTD_human