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Fusion gene ID: 10293 |
FusionGeneSummary for DNER_TRIP12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNER_TRIP12 | Fusion gene ID: 10293 | Hgene | Tgene | Gene symbol | DNER | TRIP12 | Gene ID | 92737 | 9320 |
| Gene name | delta/notch like EGF repeat containing | thyroid hormone receptor interactor 12 | |
| Synonyms | UNQ26|bet | MRD49|TRIP-12|ULF | |
| Cytomap | 2q36.3 | 2q36.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | delta and Notch-like epidermal growth factor-related receptorH_NH0150O02.1WUGSC:H_NH0150O02.1delta-notch-like EGF repeat-containing transmembrane | E3 ubiquitin-protein ligase TRIP12E3 ubiquitin-protein ligase for ArfHECT-type E3 ubiquitin transferase TRIP12TR-interacting protein 12probable E3 ubiquitin-protein ligase TRIP12thyroid receptor interacting protein 12 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8NFT8 | Q14669 | |
| Ensembl transtripts involved in fusion gene | ENST00000341772, ENST00000482831, | ENST00000283943, ENST00000389045, ENST00000389044, ENST00000543084, ENST00000409677, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 4=120 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DNER [Title/Abstract] AND TRIP12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRIP12 | GO:0006511 | ubiquitin-dependent protein catabolic process | 18627766|20208519 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AN-A0FJ-01A | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000341772 | ENST00000283943 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| In-frame | ENST00000341772 | ENST00000389045 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| In-frame | ENST00000341772 | ENST00000389044 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| 5CDS-intron | ENST00000341772 | ENST00000543084 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| 5CDS-intron | ENST00000341772 | ENST00000409677 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| intron-3CDS | ENST00000482831 | ENST00000283943 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| intron-3CDS | ENST00000482831 | ENST00000389045 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| intron-3CDS | ENST00000482831 | ENST00000389044 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| intron-intron | ENST00000482831 | ENST00000543084 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
| intron-intron | ENST00000482831 | ENST00000409677 | DNER | chr2 | 230411663 | - | TRIP12 | chr2 | 230650571 | - |
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FusionProtFeatures for DNER_TRIP12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNER | TRIP12 |
| E3 ubiquitin-protein ligase involved in ubiquitin fusiondegradation (UFD) pathway and regulation of DNA repair. Part ofthe ubiquitin fusion degradation (UFD) pathway, a process thatmediates ubiquitination of protein at their N-terminus,regardeless of the presence of lysine residues in target proteins.In normal cells, mediates ubiquitination and degradation ofisoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressorrequired for p53/TP53 activation under oncogenic stress. In cancercells, however, isoform p19ARF/ARF and TRIP12 are located indifferent cell compartments, preventing isoform p19ARF/ARFubiquitination and degradation. Does not mediate ubiquitination ofisoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1and SMARCE1, leading to their degradation. Ubiquitination anddegradation of target proteins is regulated by interaction withproteins such as MYC, TRADD or SMARCC1, which disrupt theinteraction between TRIP12 and target proteins. Acts as a keyregulator of DNA damage response by acting as a suppressor ofRNF168, an E3 ubiquitin-protein ligase that promotes accumulationof 'Lys-63'-linked histone H2A and H2AX at DNA damage sites,thereby acting as a guard against excessive spreading ofubiquitinated chromatin at damaged chromosomes.{ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681,ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358,ECO:0000269|PubMed:22884692}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 44_92 | 331 | 738 | Domain | EGF-like 1 |
| Hgene | DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 94_133 | 331 | 738 | Domain | EGF-like 2 |
| Tgene | >TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000283943 | - | 31 | 41 | 1885_1992 | 1590 | 1993 | Domain | HECT |
| Tgene | >TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000389044 | - | 32 | 42 | 1885_1992 | 1638 | 2041 | Domain | HECT |
| Tgene | >TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000389045 | - | 29 | 39 | 1885_1992 | 1320 | 1723 | Domain | HECT |
| Tgene | >TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000389045 | - | 29 | 39 | 1496_1570 | 1320 | 1723 | Region | Note=K-box |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 309_348 | 331 | 738 | Domain | EGF-like 3 |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 349_390 | 331 | 738 | Domain | EGF-like 4 |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 392_428 | 331 | 738 | Domain | EGF-like 5 |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 430_466 | 331 | 738 | Domain | EGF-like 6 |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 468_503 | 331 | 738 | Domain | EGF-like 7 |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 505_541 | 331 | 738 | Domain | EGF-like 8%3B calcium-binding |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 543_579 | 331 | 738 | Domain | EGF-like 9 |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 546_568 | 331 | 738 | Domain | Note=Follistatin-like |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 581_617 | 331 | 738 | Domain | EGF-like 10%3B calcium-binding |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 35_640 | 331 | 738 | Topological domain | Extracellular |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 662_737 | 331 | 738 | Topological domain | Cytoplasmic |
| Hgene | >DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 641_661 | 331 | 738 | Transmembrane | Helical |
| Tgene | TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000283943 | - | 31 | 41 | 749_836 | 1590 | 1993 | Domain | WWE |
| Tgene | TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000389044 | - | 32 | 42 | 749_836 | 1638 | 2041 | Domain | WWE |
| Tgene | TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000389045 | - | 29 | 39 | 749_836 | 1320 | 1723 | Domain | WWE |
| Tgene | TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000283943 | - | 31 | 41 | 1496_1570 | 1590 | 1993 | Region | Note=K-box |
| Tgene | TRIP12 | chr2:230411663 | chr2:230650571 | ENST00000389044 | - | 32 | 42 | 1496_1570 | 1638 | 2041 | Region | Note=K-box |
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FusionGeneSequence for DNER_TRIP12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000283943_chr2_230650571_-_734aa MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGAN CQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQP KTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLL EEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSERTVNREELLKQAESVMQDLGSSRAMLEIQ YENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIM DFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGF PNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGY THDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLL >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000389045_chr2_230650571_-_734aa MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGAN CQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQP KTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLL EEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSERTVNREELLKQAESVMQDLGSSRAMLEIQ YENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIM DFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGF PNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGY THDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLL >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000389044_chr2_230650571_-_734aa MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGAN CQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQP KTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLL EEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSERTVNREELLKQAESVMQDLGSSRAMLEIQ YENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIM DFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGF PNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGY THDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000283943_chr2_230650571_-_2202nt ATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCCGCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGC AGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCCGGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACC TCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAGCCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAAC TGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCATGGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTC TGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCC CGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCG AAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCT GCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGG AAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGACGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTG GAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTG GTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCA GAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCTGTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAG TATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTTTATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTT TGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAAGAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTT CCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAGATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATG GATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAATGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTT GACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGACATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACC AAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGCTGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTT CCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACTATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCA CTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGATTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCG GAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGGGATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTAT ACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGTAGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACT GGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCACCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCA GATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAGTTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTG >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000389045_chr2_230650571_-_2202nt ATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCCGCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGC AGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCCGGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACC TCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAGCCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAAC TGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCATGGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTC TGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCC CGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCG AAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCT GCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGG AAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGACGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTG GAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTG GTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCA GAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCTGTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAG TATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTTTATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTT TGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAAGAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTT CCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAGATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATG GATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAATGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTT GACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGACATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACC AAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGCTGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTT CCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACTATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCA CTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGATTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCG GAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGGGATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTAT ACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGTAGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACT GGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCACCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCA GATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAGTTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTG >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000389044_chr2_230650571_-_2202nt ATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCCGCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGC AGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCCGGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACC TCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAGCCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAAC TGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCATGGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTC TGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCC CGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCG AAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCT GCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGG AAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGACGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTG GAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTG GTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCA GAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCTGTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAG TATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTTTATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTT TGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAAGAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTT CCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAGATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATG GATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAATGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTT GACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGACATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACC AAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGCTGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTT CCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACTATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCA CTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGATTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCG GAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGGGATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTAT ACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGTAGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACT GGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCACCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCA GATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAGTTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000283943_chr2_230650571_-_6053nt CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGC CGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCC GCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCC GGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAG CCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCA CTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATC CTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAG GTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCA GTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTG AATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAAT GACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCT GTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTT TATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAG ATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAA TGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGAC ATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGC TGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGA TTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGG GATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGT AGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCA CCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCA TAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCTAATGTTATCACCTGAGTCAAGGAAACATGT TACGCCTTCTTGTTGTAGGAAAAACGGCTTGCAGATTATAAAGAGACATTTGGTTGATATTCATTAATGGCCCCATGGACTTAAAGTGAT CAGGCCCTAAAACGTTGTTGTGATGAGGTTTCTTTAGCAAGTTCTTGTTTAAATTATCATTTATTTGATGAGTGAAGTTTTTAACATGCT TTGCTGTGTGAAATTTAAAAAAGGGATGTTTTTCCAGGCTGGAACAATAAATGTGGCTGTGCAGTTTAATTCTGGGCTGTGTGTATCCAT CTAGCTAAGTCTGCAGTTTTCTTTCCTCCAAAGACAACTCTTGTACATAAGTACAGAAATTTAAGCTCACATGTATTTGACAAATATAGT TTAGTAGACTAGCTCTATGTGCTTTTCACTTTCCTCTGATTTTCTCTCCCTGATTCATTATTATCTGTGCAGCTCACAGTTTTTTTTTTG TATACAACTCACAGTTCTCAAATTTTCGTTACCCATGGGCTTCTGTTGTCCCATGTTCTCTCCAGTTAAGATCTAATTTAAAATTCATTG GATTGAAATTTATTGAATATAATTCAGCTTTTGTAACTAGGTAGACTTTTCTTATAGTTTAGTTTTAATATAGTTTAGGGTATTACTGGC TTTTTCCCAGGTGACACACTAAGGACTGTTTACATGGCAATTCCAGCAGCAACAGCCTCTGGAATGAGACAAGGAAAGCTCATTTGTTTC TTTTATGAAGGTTAAGAAGTCTACAGCTTGGGCTGGCCGGTATTTATTATTCTGTGGCCAGAGGATTTTAAATTAATGTAAATTTTTTAA ACAAAATAAGCAGTTTTCCTTCCCTGTTGGAGTAAAAAAATTTTTTTCCCTTTGTTGTTTTACGTTTTTGTTCATAGTCTTCTTTATTCC ACGCTCCTCTTCCCCTTCTCCCAGTGCTGACTTGGGACAAAACAGTTCAGCCTTTGTCTCGACGCAGATAAAAGCACCTGTAAGCAATGC TGTCCAGTCATTTTATGTGCTGATTTCTCAAATCTGCAATAATCCATCAGGTTAATGTTTTTACCTGAAAATAAAGAAAGTTTGCTTCAC CTTTTTGTTTATAGTTTTGTGCTGTATGCATAACTTTCAATTGTATAGATGTATTTCAATGCAAGGAAATCCACATATCTCCATGATTCG GGTCATGGCTGATTTTGCTATTCAAACAATTTATAATAGCAACTTGAAGAAACTAAAATGTGAAGAGAAAATGGGAGGAGATTCCTTCCT AAGGTCCAAAACTAGGCCTGTGGCATAAATTTGAAGGAATTTTCCATAATTCATCTCCTTGAAAATAAGAGATGAGCTAGTTTTTTTTTT TAATTGAACTTTGAGAAATCAATTTTTTTGACTGTTCTGTAAGTTTTAATTAATTGACACAAAAGCCCTTTTCCCTATCCCACCACCCAA AAGAAACTCAGTGGCTTGTTTGACATAGATTGCTGTGTCAATTTACACTTAAATGGCCTTATATGGAAATGTCCCCTCCTGAGAGTTCAC TTGGGCAGTGACCCCATTAAGTGGAAGGGAACTGTCAGAGGAGTTGGGGGCAGAGAATTCTCTCCCTGTCTCTGCAGAGACTGACAAGTG AATGGCTTTTCCCTGAAATCCAAGAAGGGAATTGTGTTTCTGCAGTTTTCACCACTAACAGCACAGTTGCTGAGCAGCTTCATCAAGTGA AGTTAAAGACTGAAACAATTTGTTTTCAACTGTTCTGATATCTTCCTGCAAATTAAGCACAAGGATTTTTGTGTGAACATAGCATTTTGT TCCTGATTTTTAAAGGGTTCTGTTAAAATTTAGACATGTATAAACAAAATAATGTTTCATCTGTACTTGACATTTTATCCATGTTGCAGC CCTGGCAAATTTGGCCTCATTGATTCCAGCATCTAATAAGTATATATGATGATTTTGACTCAAACTCTAAAGTCTTGAGTGTTTCAAAGT CAGTCGTTACCTGTTTAAAAGCCTCAGCCTTTAGCTTATTCCTCCTTCAATACACGGGACCTTTGGTTAATTTGGGGCAGGAAAACTCTT AAAGTAATCTCTCTTGGCAGAGGCCTTATTGCACCAGAGGGAAAAAGTATATACTTCATTTGCTGTTACTCCAGTTATGCCTTAAATTCA TTTGCTTGGTAATCCTATCAACGAGCACTAACTTCTTAGTATACTTTAAACACTTAGTTGGGTAACAACTGAGATTTTGTTGTCCTTTAT TTTTTGCTGAGATGGAGTCAGTCAGATGTTAGTCATAGCTAACACCGAATTTGTGTTGTCATTTAGACAGTTACTGATTCGATCTGCTTT ATATATGAGAACGTATTTTTAACTATTCCAAGAAGGAAGAGGTAGCTAAATGTAATCCCCTCTTCCTATCCCCCCAGAAAACTGAACTGT AAGTTCTAGGTAGACTAATTGGGAGCAGACACGGAGTTTTAGATGCCTTAGCCAAACCCAGCAGAAACCTTTCACACAGCCACTCATCGT AAGAAACGCAGATTTTTCTCTTCTCATGCTTGTCTCTGGTTCCCTGCATTTGTAGTGACAGAACTTTCACTAGCAGGATATAAAGAAAGT AATTATGCTTGGAGTCCCTCTTTACTGGGTTTGAGTTAGGTGCATAACATGGAAAGGAGTGGTGCCTTCAAATGAATGTGACCACTCCGT ATTGTGGAGTGACTTCCCTAGGGCATCCTATACATCCTACCACAGAAGGCCAAGGGACAGAGCACCAACTTCAGTATCCAAGAAATTAGA TCCACAACTCTTGATTTTCCACACTGAGGACTGTCGCGAGTAAGTTGTAAGTTTGCCGTCTTCCTTCTGGCTTAGCAGGTGCTGCAGCTG TACTCTCGACTCCTGTCTGTGAGCGTGAGCTCAGGAAATGAGAGTGGAGTCTATTCCAAAAAAAAAATGTGATGAAGTTTTTCATAAAAG TGCATTCATATGCCAAATCCTTTTTGGAGGATTCTGGATGCTATTGTTCATTTCTCTACTAGTAAAATGATCAAGCCTTCATTTATTTTA GGCTTTGTTTTTTGATCCATTTTGTTTTCCCTGCTGTAATGAGAATAATTGTTTGGAAATGTCATATTCTGTATTTATGATTCTCTGAGA AATGCTTTTGTATAAGTCTTAGGTTTGACATTGCAGTAGTTGACATACACGGTAAAGGATAACCTAGTGACAAATCACTGAAGATGCTTC CTTTGTTACCTCAAAAAAAAAAATCCAGACAAAATAGCATTTATAAATATAGAAAACAGGATTGGCTGTTTTCCAAGAACTTCAAGTTAA CAATTCTTATGCAAGGAAAAGTTCTTAATGCTAAAGACTTGTTCTGCATGAAGGAGACATTCTTTAATAATGGAAGAGGTGGTTTTATTT TTACTACAAGCCGACTCATATTTCCAAACCTATAACCAATTGCTGATCTCCTGTGTAAAGCATTTTTTTCCTTTTATCTGAAACAGTGAT TTATATGAACTGTTGGAATAATGGAACCTCAAACTACAGATGTGTATGTAAAATTGCATAAATGCACTGACTTCCTTCTCCCTGACTATA >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000389045_chr2_230650571_-_2450nt CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGC CGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCC GCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCC GGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAG CCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCA CTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATC CTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAG GTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCA GTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTG AATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAAT GACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCT GTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTT TATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAG ATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAA TGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGAC ATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGC TGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGA TTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGG GATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGT AGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCA CCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCA TAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCTAATGTTATCACCTGAGTCAAGGAAACATGT >In-frame_DNER_ENST00000341772_chr2_230411663_-_TRIP12_ENST00000389044_chr2_230650571_-_2450nt CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGC CGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCC GCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCC GGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAG CCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCA CTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATC CTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAG GTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCA GTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTG AATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAAT GACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCT GTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTT TATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAG ATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAA TGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGAC ATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGC TGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGA TTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGG GATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGT AGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCA CCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCA TAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCTAATGTTATCACCTGAGTCAAGGAAACATGT |
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FusionGenePPI for DNER_TRIP12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DNER | TRIM25 | TRIP12 | NAE1, USP11, USP7, MEPCE, CDK9, SMARCE1, CDKN2A, MYC, CLSTN1, CARNS1, SIRT7, TRADD, NMI, UBE2D1, UBE2L3, ALYREF, ESR1, VCP, RNF168, SMAD9, CFTR, SOX6, RPA3, RPA2, RPA1, GNL3, UBC, UBE4B, PTF1A, OBSL1, CCDC8, EED, BCAT1, EIF3I, RP2, IFI16, HIST1H2BG, SRPK2, CEP19, EXOSC9, VHL, PHF8, FAM46A, TEAD2, SNW1, CAPN1, KBTBD7, MECP2, OPCML, MTNR1A, MTNR1B, ERG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 44_133 | 331 | 738 | NOTCH1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | DNER | chr2:230411663 | chr2:230650571 | ENST00000341772 | - | 5 | 13 | 677_680 | 331 | 738 | AP1G1 and somatodendritic targeting |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNER_TRIP12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNER_TRIP12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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