FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10291

FusionGeneSummary for DNASE2_SMR3B

check button Fusion gene summary
Fusion gene informationFusion gene name: DNASE2_SMR3B
Fusion gene ID: 10291
HgeneTgene
Gene symbol

DNASE2

SMR3B

Gene ID

1777

10879

Gene namedeoxyribonuclease 2, lysosomalsubmaxillary gland androgen regulated protein 3B
SynonymsDNASE2A|DNL|DNL2P-B|PBII|PRL3|PROL3|SMR1B
Cytomap

19p13.13

4q13.3

Type of geneprotein-codingprotein-coding
Descriptiondeoxyribonuclease-2-alphaDNase II alphaDNase II, lysosomalR31240_2acid DNasedeoxyribonuclease II alphadeoxyribonuclease II, lysosomallysosomal DNase IIsubmaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog B
Modification date2018052320180523
UniProtAcc

O00115

P02814

Ensembl transtripts involved in fusion geneENST00000222219, ENST00000538460, 
ENST00000504825, ENST00000304915, 
Fusion gene scores* DoF score6 X 5 X 3=909 X 8 X 2=144
# samples 73
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/144*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNASE2 [Title/Abstract] AND SMR3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0G0-01ADNASE2chr19

12989318

-SMR3Bchr4

71255563

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000222219ENST00000504825DNASE2chr19

12989318

-SMR3Bchr4

71255563

+
intron-3CDSENST00000222219ENST00000304915DNASE2chr19

12989318

-SMR3Bchr4

71255563

+
intron-3CDSENST00000538460ENST00000504825DNASE2chr19

12989318

-SMR3Bchr4

71255563

+
intron-3CDSENST00000538460ENST00000304915DNASE2chr19

12989318

-SMR3Bchr4

71255563

+

Top

FusionProtFeatures for DNASE2_SMR3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNASE2

O00115

SMR3B

P02814

Hydrolyzes DNA under acidic conditions with a preferencefor double-stranded DNA. Plays a major role in the degradation ofnuclear DNA in cellular apoptosis during development. Necessaryfor proper fetal development and for definitive erythropoiesis infetal liver, where it degrades nuclear DNA expelled from erythroidprecursor cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DNASE2_SMR3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DNASE2_SMR3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNASE2RUVBL2, RUVBL1, OPA1, RRM1, DNAJB11, XRN1, FBXO6, CANX, TRIM25SMR3BRAD21, UBQLN1, UBTD2, RASSF10, BCHE, TNFRSF19, SNRPF


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DNASE2_SMR3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DNASE2_SMR3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource