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Fusion gene ID: 10291 |
FusionGeneSummary for DNASE2_SMR3B |
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Fusion gene information | Fusion gene name: DNASE2_SMR3B | Fusion gene ID: 10291 | Hgene | Tgene | Gene symbol | DNASE2 | SMR3B | Gene ID | 1777 | 10879 |
Gene name | deoxyribonuclease 2, lysosomal | submaxillary gland androgen regulated protein 3B | |
Synonyms | DNASE2A|DNL|DNL2 | P-B|PBII|PRL3|PROL3|SMR1B | |
Cytomap | 19p13.13 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | deoxyribonuclease-2-alphaDNase II alphaDNase II, lysosomalR31240_2acid DNasedeoxyribonuclease II alphadeoxyribonuclease II, lysosomallysosomal DNase II | submaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O00115 | P02814 | |
Ensembl transtripts involved in fusion gene | ENST00000222219, ENST00000538460, | ENST00000504825, ENST00000304915, | |
Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 9 X 8 X 2=144 |
# samples | 7 | 3 | |
** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/144*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNASE2 [Title/Abstract] AND SMR3B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0G0-01A | DNASE2 | chr19 | 12989318 | - | SMR3B | chr4 | 71255563 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000222219 | ENST00000504825 | DNASE2 | chr19 | 12989318 | - | SMR3B | chr4 | 71255563 | + |
intron-3CDS | ENST00000222219 | ENST00000304915 | DNASE2 | chr19 | 12989318 | - | SMR3B | chr4 | 71255563 | + |
intron-3CDS | ENST00000538460 | ENST00000504825 | DNASE2 | chr19 | 12989318 | - | SMR3B | chr4 | 71255563 | + |
intron-3CDS | ENST00000538460 | ENST00000304915 | DNASE2 | chr19 | 12989318 | - | SMR3B | chr4 | 71255563 | + |
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FusionProtFeatures for DNASE2_SMR3B |
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Hgene | Tgene |
DNASE2 | SMR3B |
Hydrolyzes DNA under acidic conditions with a preferencefor double-stranded DNA. Plays a major role in the degradation ofnuclear DNA in cellular apoptosis during development. Necessaryfor proper fetal development and for definitive erythropoiesis infetal liver, where it degrades nuclear DNA expelled from erythroidprecursor cells. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNASE2_SMR3B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNASE2_SMR3B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DNASE2 | RUVBL2, RUVBL1, OPA1, RRM1, DNAJB11, XRN1, FBXO6, CANX, TRIM25 | SMR3B | RAD21, UBQLN1, UBTD2, RASSF10, BCHE, TNFRSF19, SNRPF |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNASE2_SMR3B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNASE2_SMR3B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |