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Fusion gene ID: 10285 |
FusionGeneSummary for DNALI1_CXCL1 |
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Fusion gene information | Fusion gene name: DNALI1_CXCL1 | Fusion gene ID: 10285 | Hgene | Tgene | Gene symbol | DNALI1 | CXCL1 | Gene ID | 7802 | 2919 |
Gene name | dynein axonemal light intermediate chain 1 | C-X-C motif chemokine ligand 1 | |
Synonyms | P28|dJ423B22.5|hp28 | FSP|GRO1|GROa|MGSA|MGSA-a|NAP-3|SCYB1 | |
Cytomap | 1p34.3 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | axonemal dynein light intermediate polypeptide 1dJ423B22.5 (axonemal dynein light chain (hp28))dynein, axonemal, light intermediate polypeptide 1inner dynein arm light chain, axonemalinner dynein arm, homolog of clamydomonas | growth-regulated alpha proteinC-X-C motif chemokine 1GRO-alpha(1-73)GRO1 oncogene (melanoma growth stimulating activity, alpha)GRO1 oncogene (melanoma growth-stimulating activity)MGSA alphachemokine (C-X-C motif) ligand 1 (melanoma growth stimulatin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O14645 | P09341 | |
Ensembl transtripts involved in fusion gene | ENST00000296218, ENST00000541606, ENST00000497858, | ENST00000509101, ENST00000395761, | |
Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DNALI1 [Title/Abstract] AND CXCL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CD364755 | DNALI1 | chr1 | 38034608 | + | CXCL1 | chr4 | 74735222 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000296218 | ENST00000509101 | DNALI1 | chr1 | 38034608 | + | CXCL1 | chr4 | 74735222 | - |
intron-3UTR | ENST00000296218 | ENST00000395761 | DNALI1 | chr1 | 38034608 | + | CXCL1 | chr4 | 74735222 | - |
intron-3UTR | ENST00000541606 | ENST00000509101 | DNALI1 | chr1 | 38034608 | + | CXCL1 | chr4 | 74735222 | - |
intron-3UTR | ENST00000541606 | ENST00000395761 | DNALI1 | chr1 | 38034608 | + | CXCL1 | chr4 | 74735222 | - |
intron-3UTR | ENST00000497858 | ENST00000509101 | DNALI1 | chr1 | 38034608 | + | CXCL1 | chr4 | 74735222 | - |
intron-3UTR | ENST00000497858 | ENST00000395761 | DNALI1 | chr1 | 38034608 | + | CXCL1 | chr4 | 74735222 | - |
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FusionProtFeatures for DNALI1_CXCL1 |
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Hgene | Tgene |
DNALI1 | CXCL1 |
May play a dynamic role in flagellar motility. | Has chemotactic activity for neutrophils. May play arole in inflammation and exerts its effects on endothelial cellsin an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-foldhigher chemotactic activity. {ECO:0000269|PubMed:10095777}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNALI1_CXCL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNALI1_CXCL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNALI1_CXCL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNALI1_CXCL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CXCL1 | C0020517 | Hypersensitivity | 1 | CTD_human |
Tgene | CXCL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CXCL1 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
Tgene | CXCL1 | C0032285 | Pneumonia | 1 | CTD_human |
Tgene | CXCL1 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Tgene | CXCL1 | C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
Tgene | CXCL1 | C0036982 | Shock, Hemorrhagic | 1 | CTD_human |
Tgene | CXCL1 | C0085129 | Bronchial Hyperreactivity | 1 | CTD_human |
Tgene | CXCL1 | C0241910 | Hepatitis, Autoimmune | 1 | CTD_human |
Tgene | CXCL1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | CXCL1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |