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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10285

FusionGeneSummary for DNALI1_CXCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: DNALI1_CXCL1
Fusion gene ID: 10285
HgeneTgene
Gene symbol

DNALI1

CXCL1

Gene ID

7802

2919

Gene namedynein axonemal light intermediate chain 1C-X-C motif chemokine ligand 1
SynonymsP28|dJ423B22.5|hp28FSP|GRO1|GROa|MGSA|MGSA-a|NAP-3|SCYB1
Cytomap

1p34.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionaxonemal dynein light intermediate polypeptide 1dJ423B22.5 (axonemal dynein light chain (hp28))dynein, axonemal, light intermediate polypeptide 1inner dynein arm light chain, axonemalinner dynein arm, homolog of clamydomonasgrowth-regulated alpha proteinC-X-C motif chemokine 1GRO-alpha(1-73)GRO1 oncogene (melanoma growth stimulating activity, alpha)GRO1 oncogene (melanoma growth-stimulating activity)MGSA alphachemokine (C-X-C motif) ligand 1 (melanoma growth stimulatin
Modification date2018052320180523
UniProtAcc

O14645

P09341

Ensembl transtripts involved in fusion geneENST00000296218, ENST00000541606, 
ENST00000497858, 
ENST00000509101, 
ENST00000395761, 
Fusion gene scores* DoF score3 X 4 X 2=241 X 1 X 1=1
# samples 31
** MAII scorelog2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: DNALI1 [Title/Abstract] AND CXCL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD364755DNALI1chr1

38034608

+CXCL1chr4

74735222

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000296218ENST00000509101DNALI1chr1

38034608

+CXCL1chr4

74735222

-
intron-3UTRENST00000296218ENST00000395761DNALI1chr1

38034608

+CXCL1chr4

74735222

-
intron-3UTRENST00000541606ENST00000509101DNALI1chr1

38034608

+CXCL1chr4

74735222

-
intron-3UTRENST00000541606ENST00000395761DNALI1chr1

38034608

+CXCL1chr4

74735222

-
intron-3UTRENST00000497858ENST00000509101DNALI1chr1

38034608

+CXCL1chr4

74735222

-
intron-3UTRENST00000497858ENST00000395761DNALI1chr1

38034608

+CXCL1chr4

74735222

-

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FusionProtFeatures for DNALI1_CXCL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNALI1

O14645

CXCL1

P09341

May play a dynamic role in flagellar motility. Has chemotactic activity for neutrophils. May play arole in inflammation and exerts its effects on endothelial cellsin an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-foldhigher chemotactic activity. {ECO:0000269|PubMed:10095777}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNALI1_CXCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNALI1_CXCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNALI1_CXCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNALI1_CXCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCXCL1C0020517Hypersensitivity1CTD_human
TgeneCXCL1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCXCL1C0024117Chronic Obstructive Airway Disease1CTD_human
TgeneCXCL1C0032285Pneumonia1CTD_human
TgeneCXCL1C0035126Reperfusion Injury1CTD_human
TgeneCXCL1C0035228Respiratory Hypersensitivity1CTD_human
TgeneCXCL1C0036982Shock, Hemorrhagic1CTD_human
TgeneCXCL1C0085129Bronchial Hyperreactivity1CTD_human
TgeneCXCL1C0241910Hepatitis, Autoimmune1CTD_human
TgeneCXCL1C3495559Juvenile arthritis1CTD_human
TgeneCXCL1C4277682Chemical and Drug Induced Liver Injury1CTD_human