FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10282

FusionGeneSummary for DNAJC8_ZNF3

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC8_ZNF3
Fusion gene ID: 10282
HgeneTgene
Gene symbol

DNAJC8

ZNF3

Gene ID

22826

7551

Gene nameDnaJ heat shock protein family (Hsp40) member C8zinc finger protein 3
SynonymsHSPC331|SPF31A8-51|HF.12|KOX25|PP838|Zfp113
Cytomap

1p35.3

7q22.1

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 8DnaJ (Hsp40) homolog, subfamily C, member 8splicing protein spf31zinc finger protein 3C2-H2 type zinc finger proteinzinc finger protein HF.12zinc finger protein HZF3.1zinc finger protein KOX25
Modification date2018052320180523
UniProtAcc

O75937

P17036

Ensembl transtripts involved in fusion geneENST00000263697, ENST00000489277, 
ENST00000413658, ENST00000424697, 
ENST00000303915, ENST00000299667, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 2 X 3=18
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNAJC8 [Title/Abstract] AND ZNF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-AA6D-01ADNAJC8chr1

28559432

-ZNF3chr7

99675056

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263697ENST00000413658DNAJC8chr1

28559432

-ZNF3chr7

99675056

-
5CDS-5UTRENST00000263697ENST00000424697DNAJC8chr1

28559432

-ZNF3chr7

99675056

-
5CDS-5UTRENST00000263697ENST00000303915DNAJC8chr1

28559432

-ZNF3chr7

99675056

-
5CDS-5UTRENST00000263697ENST00000299667DNAJC8chr1

28559432

-ZNF3chr7

99675056

-
5UTR-5UTRENST00000489277ENST00000413658DNAJC8chr1

28559432

-ZNF3chr7

99675056

-
5UTR-5UTRENST00000489277ENST00000424697DNAJC8chr1

28559432

-ZNF3chr7

99675056

-
5UTR-5UTRENST00000489277ENST00000303915DNAJC8chr1

28559432

-ZNF3chr7

99675056

-
5UTR-5UTRENST00000489277ENST00000299667DNAJC8chr1

28559432

-ZNF3chr7

99675056

-

Top

FusionProtFeatures for DNAJC8_ZNF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC8

O75937

ZNF3

P17036

Suppresses polyglutamine (polyQ) aggregation of ATXN3 inneuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}. Involved in cell differentiation and/or proliferation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DNAJC8_ZNF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DNAJC8_ZNF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNAJC8SF3A2, IKBKG, SRRM1, SRRM2, APP, RAP1A, PIN4, TPX2, HMGA1, FBXO25, SRPK2, SRPK1, HECW2, ANXA2, LOC100128588, HUWE1, HSPA5, HSPA9, METTL13, PDLIM5, HSPA4L, HYOU1, NEDD8, EWSR1, EGR1, XRCC3, REEP5, EMC2, MMGT1, PIGS, CNTROB, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, UBE2N, G3BP1ZNF3ZNF212, FHL2, ID3, ZNF3, BAG3, TRAF4, MTUS2, SSX2IP, SHCBP1, KBTBD7, PTPRK, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DNAJC8_ZNF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DNAJC8_ZNF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource