![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 10282 |
FusionGeneSummary for DNAJC8_ZNF3 |
![]() |
Fusion gene information | Fusion gene name: DNAJC8_ZNF3 | Fusion gene ID: 10282 | Hgene | Tgene | Gene symbol | DNAJC8 | ZNF3 | Gene ID | 22826 | 7551 |
Gene name | DnaJ heat shock protein family (Hsp40) member C8 | zinc finger protein 3 | |
Synonyms | HSPC331|SPF31 | A8-51|HF.12|KOX25|PP838|Zfp113 | |
Cytomap | 1p35.3 | 7q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily C member 8DnaJ (Hsp40) homolog, subfamily C, member 8splicing protein spf31 | zinc finger protein 3C2-H2 type zinc finger proteinzinc finger protein HF.12zinc finger protein HZF3.1zinc finger protein KOX25 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O75937 | P17036 | |
Ensembl transtripts involved in fusion gene | ENST00000263697, ENST00000489277, | ENST00000413658, ENST00000424697, ENST00000303915, ENST00000299667, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 2 X 3=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DNAJC8 [Title/Abstract] AND ZNF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-VQ-AA6D-01A | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000263697 | ENST00000413658 | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
5CDS-5UTR | ENST00000263697 | ENST00000424697 | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
5CDS-5UTR | ENST00000263697 | ENST00000303915 | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
5CDS-5UTR | ENST00000263697 | ENST00000299667 | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
5UTR-5UTR | ENST00000489277 | ENST00000413658 | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
5UTR-5UTR | ENST00000489277 | ENST00000424697 | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
5UTR-5UTR | ENST00000489277 | ENST00000303915 | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
5UTR-5UTR | ENST00000489277 | ENST00000299667 | DNAJC8 | chr1 | 28559432 | - | ZNF3 | chr7 | 99675056 | - |
Top |
FusionProtFeatures for DNAJC8_ZNF3 |
![]() |
Hgene | Tgene |
DNAJC8 | ZNF3 |
Suppresses polyglutamine (polyQ) aggregation of ATXN3 inneuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}. | Involved in cell differentiation and/or proliferation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for DNAJC8_ZNF3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for DNAJC8_ZNF3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DNAJC8 | SF3A2, IKBKG, SRRM1, SRRM2, APP, RAP1A, PIN4, TPX2, HMGA1, FBXO25, SRPK2, SRPK1, HECW2, ANXA2, LOC100128588, HUWE1, HSPA5, HSPA9, METTL13, PDLIM5, HSPA4L, HYOU1, NEDD8, EWSR1, EGR1, XRCC3, REEP5, EMC2, MMGT1, PIGS, CNTROB, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, UBE2N, G3BP1 | ZNF3 | ZNF212, FHL2, ID3, ZNF3, BAG3, TRAF4, MTUS2, SSX2IP, SHCBP1, KBTBD7, PTPRK, LMNA |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DNAJC8_ZNF3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DNAJC8_ZNF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |