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Fusion gene ID: 10246 |
FusionGeneSummary for DNAJC21_SGCZ |
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Fusion gene information | Fusion gene name: DNAJC21_SGCZ | Fusion gene ID: 10246 | Hgene | Tgene | Gene symbol | DNAJC21 | SGCZ | Gene ID | 134218 | 137868 |
Gene name | DnaJ heat shock protein family (Hsp40) member C21 | sarcoglycan zeta | |
Synonyms | BMFS3|DNAJA5|GS3|JJJ1 | ZSG1 | |
Cytomap | 5p13.2 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily C member 21DnaJ (Hsp40) homolog, subfamily C, member 21DnaJ homology subfamily A member 5JJJ1 DnaJ domain protein homologdnaJ homolog subfamily A member 5 | zeta-sarcoglycanzeta-SG | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q5F1R6 | Q96LD1 | |
Ensembl transtripts involved in fusion gene | ENST00000342382, ENST00000303525, ENST00000382021, ENST00000512136, | ENST00000382080, ENST00000421524, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 5 X 4 X 5=100 |
# samples | 4 | 5 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAJC21 [Title/Abstract] AND SGCZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ACC | TCGA-OR-A5KX-01A | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000342382 | ENST00000382080 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
5CDS-intron | ENST00000342382 | ENST00000421524 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
Frame-shift | ENST00000303525 | ENST00000382080 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
5CDS-intron | ENST00000303525 | ENST00000421524 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
Frame-shift | ENST00000382021 | ENST00000382080 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
5CDS-intron | ENST00000382021 | ENST00000421524 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
intron-3CDS | ENST00000512136 | ENST00000382080 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
intron-intron | ENST00000512136 | ENST00000421524 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
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FusionProtFeatures for DNAJC21_SGCZ |
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Hgene | Tgene |
DNAJC21 | SGCZ |
May act as a co-chaperone for HSP70. May play a role inribosomal RNA (rRNA) biogenesis, possibly in the maturation of the60S subunit. Binds the precursor 45S rRNA.{ECO:0000269|PubMed:27346687}. | Component of the sarcoglycan complex, a subcomplex ofthe dystrophin-glycoprotein complex which forms a link between theF-actin cytoskeleton and the extracellular matrix. May play a rolein the maintenance of striated muscle membrane stability (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJC21_SGCZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJC21_SGCZ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DNAJC21 | VAV2, CAND1, MTERF1, ZNF622, RNF2, HSPB1, GRPEL1, EZH2, RPL10, NIPSNAP1, FBXW7 | SGCZ | SGCB, HARS, REEP5, GK, ACACA, GNPTAB, RANGRF, ATP5F1, C4orf32, SP3, RTN4, DAGLB, ATP5B |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJC21_SGCZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJC21_SGCZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SGCZ | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |