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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10241

FusionGeneSummary for DNAJC1_MYB

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC1_MYB
Fusion gene ID: 10241
HgeneTgene
Gene symbol

DNAJC1

MYB

Gene ID

64215

4602

Gene nameDnaJ heat shock protein family (Hsp40) member C1MYB proto-oncogene, transcription factor
SynonymsDNAJL1|ERdj1|HTJ1|MTJ1Cmyb|c-myb|c-myb_CDS|efg
Cytomap

10p12.31

6q23.3

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 1DnaJ (Hsp40) homolog, subfamily C, member 1DnaJ-like proteindnaJ protein homolog MTJ1transcriptional activator Myboncogene AMVproto-oncogene c-Mybv-myb avian myeloblastosis viral oncogene homolog
Modification date2018051920180527
UniProtAcc

Q96KC8

P10242

Ensembl transtripts involved in fusion geneENST00000376980, ENST00000376946, 
ENST00000483085, 		ENST00000341911, 
ENST00000316528, ENST00000442647, 
ENST00000367814, ENST00000525369, 
ENST00000534121, ENST00000533624, 
ENST00000534044, ENST00000528774, 
ENST00000531845, ENST00000527615, 
ENST00000420123, 
Fusion gene scores* DoF score8 X 7 X 4=2247 X 5 X 3=105
# samples 89
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/105*10)=-0.222392421336448
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJC1 [Title/Abstract] AND MYB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJC1

GO:0050708

regulation of protein secretion

14668352

TgeneMYB

GO:0045944

positive regulation of transcription by RNA polymerase II

10233885|20484083


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA807457DNAJC1chr10

22201941

+MYBchr6

135540310

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000376980ENST00000341911DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000316528DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000442647DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000367814DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000525369DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000534121DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000533624DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000534044DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000528774DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000531845DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000527615DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376980ENST00000420123DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000341911DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000316528DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000442647DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000367814DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000525369DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000534121DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000533624DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000534044DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000528774DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000531845DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000527615DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000376946ENST00000420123DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000341911DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000316528DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000442647DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000367814DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000525369DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000534121DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000533624DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000534044DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000528774DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000531845DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000527615DNAJC1chr10

22201941

+MYBchr6

135540310

-
intron-intronENST00000483085ENST00000420123DNAJC1chr10

22201941

+MYBchr6

135540310

-

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FusionProtFeatures for DNAJC1_MYB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC1

Q96KC8

MYB

P10242

May modulate protein synthesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJC1_MYB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJC1_MYB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJC1_MYB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJC1_MYB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNAJC1C0025202melanoma1CTD_human
TgeneMYBC0010606Adenoid Cystic Carcinoma2CTD_human
TgeneMYBC0017638Glioma2CTD_human
TgeneMYBC0004096Asthma1CTD_human
TgeneMYBC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human