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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10234

FusionGeneSummary for DNAJC17_RAB10

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC17_RAB10
Fusion gene ID: 10234
HgeneTgene
Gene symbol

DNAJC17

RAB10

Gene ID

55192

10890

Gene nameDnaJ heat shock protein family (Hsp40) member C17RAB10, member RAS oncogene family
Synonyms--
Cytomap

15q15.1

2p23.3

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 17DnaJ (Hsp40) homolog, subfamily C, member 17ras-related protein Rab-10GTP-binding protein RAB10ras-related GTP-binding protein
Modification date2018051920180523
UniProtAcc

Q9NVM6

P61026

Ensembl transtripts involved in fusion geneENST00000220496, ENST00000558727, 
ENST00000264710, ENST00000462003, 
Fusion gene scores* DoF score5 X 2 X 5=505 X 5 X 3=75
# samples 77
** MAII scorelog2(7/50*10)=0.485426827170242
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJC17 [Title/Abstract] AND RAB10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0906-01ADNAJC17chr15

41099567

-RAB10chr2

26350013

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000220496ENST00000264710DNAJC17chr15

41099567

-RAB10chr2

26350013

+
5CDS-3UTRENST00000220496ENST00000462003DNAJC17chr15

41099567

-RAB10chr2

26350013

+
intron-3CDSENST00000558727ENST00000264710DNAJC17chr15

41099567

-RAB10chr2

26350013

+
intron-3UTRENST00000558727ENST00000462003DNAJC17chr15

41099567

-RAB10chr2

26350013

+

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FusionProtFeatures for DNAJC17_RAB10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC17

Q9NVM6

RAB10

P61026

May negatively affect PAX8-induced thyroglobulin/TGtranscription. {ECO:0000250|UniProtKB:Q91WT4}. The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different set of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion (By similarity). That Rab is mainly involvedin the biosynthetic transport of proteins from the Golgi to theplasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucosetransporter-enriched vesicles delivery to the plasma membrane. Inparallel, it regulates the transport of TLR4, a toll-like receptorto the plasma membrane and therefore may be important for innateimmune response. Plays also a specific role in asymmetric proteintransport to the plasma membrane within the polarized neuron andepithelial cells. In neurons, it is involved in axonogenesisthrough regulation of vesicular membrane trafficking toward theaxonal plasma membrane while in epithelial cells, it regulatestransport from the Golgi to the basolateral membrane. Moreover,may play a role in the basolateral recycling pathway and inphagosome maturation. According to PubMed:23263280, may play arole in endoplasmic reticulum dynamics and morphology controllingtubulation along microtubules and tubules fusion. {ECO:0000250,ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164,ECO:0000269|PubMed:23263280}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAB10chr15:41099567chr2:26350013ENST00000264710+26122_125109201Nucleotide bindingGTP
TgeneRAB10chr15:41099567chr2:26350013ENST00000264710+26152_154109201Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC17chr15:41099567chr2:26350013ENST00000220496-111111_11726305Compositional biasNote=Poly-Glu
HgeneDNAJC17chr15:41099567chr2:26350013ENST00000220496-11111_7626305DomainJ
HgeneDNAJC17chr15:41099567chr2:26350013ENST00000220496-111178_24926305DomainNote=RRM
TgeneRAB10chr15:41099567chr2:26350013ENST00000264710+2638_46109201MotifEffector region
TgeneRAB10chr15:41099567chr2:26350013ENST00000264710+2618_24109201Nucleotide bindingGTP
TgeneRAB10chr15:41099567chr2:26350013ENST00000264710+2635_41109201Nucleotide bindingGTP
TgeneRAB10chr15:41099567chr2:26350013ENST00000264710+2664_68109201Nucleotide bindingGTP


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FusionGeneSequence for DNAJC17_RAB10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DNAJC17_ENST00000220496_chr15_41099567_-_RAB10_ENST00000264710_chr2_26350013_+_118aa
MAVTKELLQMDLYALLGIEEKAADKEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DNAJC17_ENST00000220496_chr15_41099567_-_RAB10_ENST00000264710_chr2_26350013_+_354nt
ATGGCAGTGACCAAGGAGCTCTTACAGATGGACCTGTACGCGCTGCTAGGCATTGAGGAGAAGGCAGCGGACAAAGAGCATGCCAATGAA
GATGTGGAAAGAATGTTACTAGGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACCTAAAGGAAAAGGAGAACAGATTGCAAGGGAG
CATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTTCCTCACGTTAGCTGAAGATATCCTTCGAAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_DNAJC17_ENST00000220496_chr15_41099567_-_RAB10_ENST00000264710_chr2_26350013_+_2818nt
AGTTGTAGTACGAATCCGTCAGGCCGGAACCATGGCAGTGACCAAGGAGCTCTTACAGATGGACCTGTACGCGCTGCTAGGCATTGAGGA
GAAGGCAGCGGACAAAGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTAGGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACC
TAAAGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTT
CCTCACGTTAGCTGAAGATATCCTTCGAAAGACCCCTGTAAAAGAGCCCAACAGTGAAAATGTAGATATCAGCAGTGGAGGAGGCGTGAC
AGGCTGGAAGAGCAAATGCTGCTGAGCATTCTCCTGTTCCATCAGTTGCCATCCACTACCCCGTTTTCTCTTCTTGCTGCAAAATAAACC
ACTCTGTCCATTTTTAACTCTAAACAGATATTTTTGTTTCTCATCTTAACTATCCAAGCCACCTATTTTATTTGTTCTTTCATCTGTGAC
TGCTTGCTGACTTTATCATAATTTTCTTCAAACAAAAAAATGTATAGAAAAATCATGTCTGTGAGTTCATTTTTAAATGTACTTGCTCAG
CTCAACTGCATTTCAGTTGTATTATAGTCCAGTTCTTATCAACATTAAAACCTATAGCAATCATTTCAAATCTATTCTGCAAATTGTATA
AGAATAAAGTTAGAATTAACAATTTTATTTTGTACAACAGTGGAATTTTCTGTCATGGATAATGTGCTTGAGTCCCTATAATCTATAGAC
ATGTGATAGCAAAAGAAACAAACAAAAGCCAGGAAAACACTCATTTTCGCCTTGAATATGTAAATGGGATTAATTTTGTCCTGTGCCTTA
TGTGGAAAGGAACTTCTTTGGTTTTCCTTTTTTGTTCTGGTGGAAGCATGTGCAGGAGACATATCATCCAAACATAAACCATTAAAATGT
TTGTGGTTTGCTTGGCTGTAATTTTCAAAGTAGTTAATTGAGGACAAAGGGTAATGCAGAAGTGATAGCTTTGGTTTGCTGAGTCTTGTT
TTAAGTGGCCTTGATATTTAAAACTATTCCTGCCACCATTTCTTCTCCTTGGCCACTTCTTCCTTGCGTCTCCCTGCATGCTGCTTTATT
TGCTTCTCCCTCCCCAACCACCTCATGGTATATTTAAGAGTGAAAGGGACAAACTAGTAGGTTTGTCAAGTTTAATATAAAGCACTGATG
TAACTTGCTAGGTAAACGGAAAGATAAGTTCTAACTGCCTACTATCCAATGTCAGTTAATTGGTGTCTTCCCCCCTCATTTGCTCTCTTC
CCTAAAATGTGTCCCAGATGCCTTCATTTGCTGTTTTACTTCTATGTTCTGCTTTTCCTCCTCTCTTTGTTCCCTTCCTGTCTATCCATT
GAGTTTATGAAATGGAAGAGTTAACTGCATGCACTAGTGTTTGGAGGGTGTTGTGGTTTGTCTTTCTAATTAGGTGTATAGCCTATTCAC
TTTCCTAGAATAAATCTCTTAACCTAAATTTGAGTAGTCTGCATTTTGGCAACTCCTCTAGCAGCTTGGTAGCCTAGTACAGGTTGTTTT
TTTAAAAAAGGAAAAGCAGGAAGGAGGAGTGAATTTTATTAACATGTTTGCCAAATGTATTGAGATTTGGCCTCTGAAGAACACTTTTTC
AGTGTTAAGTTTCTTTACCTTAAGATTCAGAAATACTTTAGAATATTATTAATTTTAAGTCCTGTCTTTACATCCTTTTGGAAAACTTGT
ATTACCATGGGTTTGGAAAAAGGACAACGAAAGGCTTTTCATGTAAAGATAAGATCTTTAGCTATCTCTAACCCTGTCCTTTTTTCACTG
CATTTTTTCTAGTTTTGCTTCATTGCTTATCATTAGGATAGGGTAAGTGAAGTTTGCTATGCTGCTAGCATCCTAAGATGATACCTTTGT
TGAAAGAATTGTGAATAGCATGATTCATTTCTAGCAGAGGCTGAGTTTAGGACAGCAGCTTCCATTGAGAAGTCTTTCTGTGTCGTGAAT
AGCATTTTAATGACCTCTTGGCTCACATAAGCAAACAACATAGGGACGTATCTGCTATGAAAATCCACAAATTTTTCAGATAGTGCCCTA
AAAACAATTTTATATGCCTCACTGGTTGTTATTCTTAGGTTATTCCCACACTTGACTTTATCATTGTTTACTACTAGTAAAAAGCAGCAT
TGCCAAATAATCCCTAATTTTCCACTAAAAATATAATGAAATGATGTTAAGCTTTTTGAAAAGTTTAGGTTAAACCTACTGTTGTTAGAT
TAATGTATTTGTTGCTTCCCTTTATCTGGAATGTGGCATTAGCTTTTTTATTTTAACCCTCTTTAATTCTTATTCAATTCCATGACTTAA
GGTTGGAGAGCTAAACACTGGGATTTTTGGATAACAGACTGACAGTTTTGCATAATTATAATCGGCATTGTACATAGAAAGGATATGGCT
ACCTTTTGTTAAATCTGCACTTTCTAAATATCAAAAAAGGGAAATGAAGTATAAATCAATTTTTGTATAATCTGTTTGAAACATGAGTTT
TATTTGCTTAATATTAGGGCTTTGCCCCTTTTCTGTAAGTCTCTTGGGATCCTGTGTAGAAGCTGTTCTCATTAAACACCAAACAGTTAA
GTCCATTCTCTGGTACTAGCTACAAATTCGGTTTCATATTCTACTTAACAATTTAAATAAACTGAAATATTTCTAGATGGTCTACTTCTG


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FusionGenePPI for DNAJC17_RAB10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNAJC17PTH1R, C1orf123, C12orf10, DHX29, ELAC2, HSPA5, KIN, TRMT6, HSPA14, HSPA9, HSPH1, HYOU1, HIST1H2BGRAB10RAB8A, AP1S1, DOK2, AURKA, SYTL3, MLPH, ENOPH1, MICAL1, PPBP, ELAVL1, EVI5L, APP, ZMPSTE24, VCP, FN1, MTNR1A, UBL4A, ITGA4, ATP4A, RPA3, RPA2, RPA1, ASB17, STAU1, OPTN, CUL7, RNF2, CFL1, GDI2, GPI, LGALS1, PPIA, FKBP2, FUBP3, HNRNPA3, MAP3K15, MDH2, PKM, TAGLN2, TKT, UBE2L3, RAB5C, RAB7A, TIAL1, UQCRC2, MED20, TCTN2, GDI1, MIRLET7A1, TSSC1, CDC73, CDH1, MTMR14, DUSP22, TTC30B, SDHA, FOXA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJC17_RAB10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJC17_RAB10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource