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Fusion gene ID: 10233 |
FusionGeneSummary for DNAJC17_PPP1R14D |
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Fusion gene information | Fusion gene name: DNAJC17_PPP1R14D | Fusion gene ID: 10233 | Hgene | Tgene | Gene symbol | DNAJC17 | PPP1R14D | Gene ID | 55192 | 54866 |
Gene name | DnaJ heat shock protein family (Hsp40) member C17 | protein phosphatase 1 regulatory inhibitor subunit 14D | |
Synonyms | - | CPI17-like|GBPI-1|GBPI1 | |
Cytomap | 15q15.1 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily C member 17DnaJ (Hsp40) homolog, subfamily C, member 17 | protein phosphatase 1 regulatory subunit 14DPKC-dependent PP1 inhibitory proteingastrointestinal and brain-specific PP1-inhibitory protein 1gut and brain phosphatase inhibitor 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NVM6 | Q9NXH3 | |
Ensembl transtripts involved in fusion gene | ENST00000220496, ENST00000558727, | ENST00000299174, ENST00000427255, | |
Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 1 X 2 X 2=4 |
# samples | 7 | 2 | |
** MAII score | log2(7/50*10)=0.485426827170242 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: DNAJC17 [Title/Abstract] AND PPP1R14D [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-55-6986-01A | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41109545 | - |
TCGA | RV | UCEC | TCGA-KP-A3W0-01A | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41108451 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000220496 | ENST00000299174 | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41109545 | - |
5CDS-intron | ENST00000220496 | ENST00000427255 | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41109545 | - |
intron-intron | ENST00000558727 | ENST00000299174 | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41109545 | - |
intron-intron | ENST00000558727 | ENST00000427255 | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41109545 | - |
In-frame | ENST00000220496 | ENST00000299174 | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41108451 | - |
Frame-shift | ENST00000220496 | ENST00000427255 | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41108451 | - |
intron-3CDS | ENST00000558727 | ENST00000299174 | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41108451 | - |
intron-3CDS | ENST00000558727 | ENST00000427255 | DNAJC17 | chr15 | 41099567 | - | PPP1R14D | chr15 | 41108451 | - |
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FusionProtFeatures for DNAJC17_PPP1R14D |
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Hgene | Tgene |
DNAJC17 | PPP1R14D |
May negatively affect PAX8-induced thyroglobulin/TGtranscription. {ECO:0000250|UniProtKB:Q91WT4}. | Inhibitor of PPP1CA. Has inhibitory activity only whenphosphorylated, creating a molecular switch for regulating thephosphorylation status of PPP1CA substrates and smooth musclecontraction. {ECO:0000269|PubMed:12974676}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >DNAJC17 | chr15:41099567 | chr15:41108451 | ENST00000220496 | - | 1 | 11 | 111_117 | 26 | 305 | Compositional bias | Note=Poly-Glu |
Hgene | >DNAJC17 | chr15:41099567 | chr15:41108451 | ENST00000220496 | - | 1 | 11 | 11_76 | 26 | 305 | Domain | J |
Hgene | >DNAJC17 | chr15:41099567 | chr15:41108451 | ENST00000220496 | - | 1 | 11 | 178_249 | 26 | 305 | Domain | Note=RRM |
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FusionGeneSequence for DNAJC17_PPP1R14D |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJC17_PPP1R14D |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DNAJC17 | PTH1R, C1orf123, C12orf10, DHX29, ELAC2, HSPA5, KIN, TRMT6, HSPA14, HSPA9, HSPH1, HYOU1, HIST1H2BG | PPP1R14D |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | PPP1R14D | chr15:41099567 | chr15:41108451 | ENST00000299174 | - | 0 | 4 | 21_25 | 85 | 146 | protein phosphatase 1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJC17_PPP1R14D |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJC17_PPP1R14D |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |