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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10224

FusionGeneSummary for DNAJC11_LDB2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC11_LDB2
Fusion gene ID: 10224
HgeneTgene
Gene symbol

DNAJC11

LDB2

Gene ID

55735

9079

Gene nameDnaJ heat shock protein family (Hsp40) member C11LIM domain binding 2
SynonymsdJ126A5.1CLIM1|LDB-2|LDB1
Cytomap

1p36.31

4p15.32

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 11DnaJ (Hsp40) homolog, subfamily C, member 11novel DnaJ domain-containing proteinLIM domain-binding protein 2LIM binding domain 2LIM domain-binding factor CLIM1LIM domain-binding factor-2carboxyl-terminal LIM domain-binding protein 1
Modification date2018052320180523
UniProtAcc

Q9NVH1

O43679

Ensembl transtripts involved in fusion geneENST00000465508, ENST00000349363, 
ENST00000377577, ENST00000294401, 
ENST00000542246, ENST00000377573, 
ENST00000515064, ENST00000441778, 
ENST00000304523, ENST00000502640, 
ENST00000503178, ENST00000503829, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 4=100
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJC11 [Title/Abstract] AND LDB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW935247DNAJC11chr1

6713367

-LDB2chr4

16785305

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000465508ENST00000515064DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000465508ENST00000441778DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000465508ENST00000304523DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000465508ENST00000502640DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000465508ENST00000503178DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000465508ENST00000503829DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000349363ENST00000515064DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000349363ENST00000441778DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000349363ENST00000304523DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000349363ENST00000502640DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000349363ENST00000503178DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000349363ENST00000503829DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377577ENST00000515064DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377577ENST00000441778DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377577ENST00000304523DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377577ENST00000502640DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377577ENST00000503178DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377577ENST00000503829DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000294401ENST00000515064DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000294401ENST00000441778DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000294401ENST00000304523DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000294401ENST00000502640DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000294401ENST00000503178DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000294401ENST00000503829DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000542246ENST00000515064DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000542246ENST00000441778DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000542246ENST00000304523DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000542246ENST00000502640DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000542246ENST00000503178DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000542246ENST00000503829DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377573ENST00000515064DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377573ENST00000441778DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377573ENST00000304523DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377573ENST00000502640DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377573ENST00000503178DNAJC11chr1

6713367

-LDB2chr4

16785305

-
intron-intronENST00000377573ENST00000503829DNAJC11chr1

6713367

-LDB2chr4

16785305

-

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FusionProtFeatures for DNAJC11_LDB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC11

Q9NVH1

LDB2

O43679

Isoform 1: Required for mitochondrial inner membraneorganization. Seems to function through its association with theMICOS complex and the mitochondrial outer membrane sortingassembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180,ECO:0000305}. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJC11_LDB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJC11_LDB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJC11_LDB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJC11_LDB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource