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Fusion gene ID: 10218 |
FusionGeneSummary for DNAJB6_AGT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJB6_AGT | Fusion gene ID: 10218 | Hgene | Tgene | Gene symbol | DNAJB6 | AGT | Gene ID | 10049 | 189 |
| Gene name | DnaJ heat shock protein family (Hsp40) member B6 | alanine--glyoxylate and serine--pyruvate aminotransferase | |
| Synonyms | DJ4|DnaJ|HHDJ1|HSJ-2|HSJ2|LGMD1D|LGMD1E|MRJ|MSJ-1 | AGT|AGT1|AGXT1|PH1|SPAT|SPT|TLH6 | |
| Cytomap | 7q36.3 | 2q37.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily B member 6DnaJ (Hsp40) homolog, subfamily B, member 6DnaJ-like 2 proteinheat shock protein J2 | serine--pyruvate aminotransferaseL-alanine: glyoxylate aminotransferase 1alanine-glyoxylate aminotransferasehepatic peroxisomal alanine:glyoxylate aminotransferase | |
| Modification date | 20180529 | 20180523 | |
| UniProtAcc | O75190 | P01019 | |
| Ensembl transtripts involved in fusion gene | ENST00000429029, ENST00000262177, ENST00000452797, ENST00000443280, ENST00000494267, | ENST00000366667, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DNAJB6 [Title/Abstract] AND AGT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJB6 | GO:0006457 | protein folding | 11896048 |
| Hgene | DNAJB6 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 11896048 |
| Hgene | DNAJB6 | GO:0045109 | intermediate filament organization | 10954706 |
| Hgene | DNAJB6 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
| Tgene | AGT | GO:0009436 | glyoxylate catabolic process | 22198249 |
| Tgene | AGT | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate | 22198249 |
| Tgene | AGT | GO:0019448 | L-cysteine catabolic process | 18492492 |
| Tgene | AGT | GO:0042853 | L-alanine catabolic process | 17696873|18492492|22198249 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-98-A53H-01A | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000429029 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| In-frame | ENST00000262177 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| In-frame | ENST00000452797 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| intron-3CDS | ENST00000443280 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| intron-3CDS | ENST00000494267 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
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FusionProtFeatures for DNAJB6_AGT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJB6 | AGT |
| Essential component of the renin-angiotensin system(RAS), a potent regulator of blood pressure, body fluid andelectrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscleas a potent vasoconstrictor, affects cardiac contractility andheart rate through its action on the sympathetic nervous system,and alters renal sodium and water absorption through its abilityto stimulate the zona glomerulosa cells of the adrenal cortex tosynthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupledreceptor MAS1. Has vasodilator and antidiuretic effects. Has anantithrombotic effect that involves MAS1-mediated release ofnitric oxide from platelets. {ECO:0000250,ECO:0000269|PubMed:10619573, ECO:0000269|PubMed:1132082,ECO:0000269|PubMed:17138938}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJB6_AGT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DNAJB6_ENST00000262177_chr7_157178305_+_AGT_ENST00000366667_chr1_230841946_-_431aa MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG FTFRNPDDVFREFFGGRDPFSFDFFEDPFEDFFGNRRGPRGSRSRGTGSFFSAFSGFPSFGSGFSSFDTGFTSFGSLGHGGLTSFSSTSF GGSGMGNFKSISTSTKMVNGRKITTKRIVENGQERVEVEEDGQLKSLTINGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDI QDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLS >In-frame_DNAJB6_ENST00000452797_chr7_157178305_+_AGT_ENST00000366667_chr1_230841946_-_382aa MPHPRILKRPKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFEDFFGNRRGPRGSRSRGTGS FFSAFSGFPSFGSGFSSFDTGFTSFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKMVNGRKITTKRIVENGQERVEVEEDGQLKSLTI NGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSP RTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DNAJB6_ENST00000262177_chr7_157178305_+_AGT_ENST00000366667_chr1_230841946_-_1293nt ATGGTGGATTACTATGAAGTTCTAGGCGTGCAGAGACATGCCTCACCCGAGGATATTAAAAAGGCATATCGGAAACTGGCACTGAAGTGG CATCCAGATAAAAATCCTGAGAATAAAGAAGAAGCAGAGAGAAAATTCAAGCAAGTAGCGGAGGCATATGAAGTGCTGTCGGATGCTAAG AAACGGGACATCTATGACAAATATGGCAAAGAAGGATTAAATGGTGGAGGAGGAGGTGGAAGTCATTTTGACAGTCCATTTGAATTTGGC TTCACATTCCGTAACCCAGATGATGTCTTCAGGGAATTTTTTGGTGGAAGGGACCCATTTTCATTTGACTTCTTTGAAGACCCTTTTGAG GACTTCTTTGGGAATCGAAGGGGTCCCCGAGGAAGCAGAAGCCGAGGGACGGGGTCGTTTTTCTCTGCGTTCAGTGGATTTCCGTCTTTT GGAAGTGGATTTTCTTCTTTTGATACAGGATTTACTTCATTTGGGTCACTAGGTCACGGGGGCCTCACTTCATTCTCTTCCACGTCATTT GGTGGTAGTGGCATGGGCAACTTCAAATCGATATCAACTTCAACTAAAATGGTTAATGGCAGAAAAATCACTACAAAGAGAATTGTCGAG AACGGTCAAGAAAGAGTAGAAGTTGAAGAAGATGGCCAGTTAAAGTCCTTAACAATAAATGGGAAGATGAAGGGCTTCTCCCTGCTGGCC GAGCCCCAGGAGTTCTGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCTGGCATGGGCACCTTCCAGCACTGGAGTGACATC CAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCCTGCCTGCTGCTGATCCAGCCTCACTATGCCTCTGACCTGGACAAG GTGGAGGGTCTCACTTTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTATCTCCCCGGACCATCCACCTGACCATGCCCCAACTGGTG CTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAGCTGCCCGCCATTCTGCACACCGAGCTGAACCTGCAAAAATTGAGC AATGACCGCATCAGGGTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCGGATGAGAGAGAGCCCACAGAGTCTACCCAACAG CTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTCCTGTTTGCTGTGTATGATCAAAGCGCCACTGCCCTGCACTTCCTG >In-frame_DNAJB6_ENST00000452797_chr7_157178305_+_AGT_ENST00000366667_chr1_230841946_-_1146nt ATGCCTCACCCGAGGATATTAAAAAGGCCTAAGAAACGGGACATCTATGACAAATATGGCAAAGAAGGATTAAATGGTGGAGGAGGAGGT GGAAGTCATTTTGACAGTCCATTTGAATTTGGCTTCACATTCCGTAACCCAGATGATGTCTTCAGGGAATTTTTTGGTGGAAGGGACCCA TTTTCATTTGACTTCTTTGAAGACCCTTTTGAGGACTTCTTTGGGAATCGAAGGGGTCCCCGAGGAAGCAGAAGCCGAGGGACGGGGTCG TTTTTCTCTGCGTTCAGTGGATTTCCGTCTTTTGGAAGTGGATTTTCTTCTTTTGATACAGGATTTACTTCATTTGGGTCACTAGGTCAC GGGGGCCTCACTTCATTCTCTTCCACGTCATTTGGTGGTAGTGGCATGGGCAACTTCAAATCGATATCAACTTCAACTAAAATGGTTAAT GGCAGAAAAATCACTACAAAGAGAATTGTCGAGAACGGTCAAGAAAGAGTAGAAGTTGAAGAAGATGGCCAGTTAAAGTCCTTAACAATA AATGGGAAGATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTCTGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCT GGCATGGGCACCTTCCAGCACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCCTGCCTGCTGCTG ATCCAGCCTCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACTTTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTATCTCCC CGGACCATCCACCTGACCATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAGCTGCCCGCCATT CTGCACACCGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGGGTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCG GATGAGAGAGAGCCCACAGAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTCCTGTTTGCTGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DNAJB6_ENST00000262177_chr7_157178305_+_AGT_ENST00000366667_chr1_230841946_-_2116nt AGTTGACGCCGCCGTGCCGCCGCCGCGTGACGCATTTCCTGTTTGTTGTTGGAGAAAGGAGAGAAAGGAAAGCGCGAGGAGCCGCCGCCA CCACCAGCGCAGCAGTCCTGGAGCTGTGAGGAGATTCGGGCCGTCACCCTGCCTCCCCTGCGTCCCGCCACCGGCCGCTTCTGTCCTCGG ACCCATTCCAACAATCTCGTAAAACATGGTGGATTACTATGAAGTTCTAGGCGTGCAGAGACATGCCTCACCCGAGGATATTAAAAAGGC ATATCGGAAACTGGCACTGAAGTGGCATCCAGATAAAAATCCTGAGAATAAAGAAGAAGCAGAGAGAAAATTCAAGCAAGTAGCGGAGGC ATATGAAGTGCTGTCGGATGCTAAGAAACGGGACATCTATGACAAATATGGCAAAGAAGGATTAAATGGTGGAGGAGGAGGTGGAAGTCA TTTTGACAGTCCATTTGAATTTGGCTTCACATTCCGTAACCCAGATGATGTCTTCAGGGAATTTTTTGGTGGAAGGGACCCATTTTCATT TGACTTCTTTGAAGACCCTTTTGAGGACTTCTTTGGGAATCGAAGGGGTCCCCGAGGAAGCAGAAGCCGAGGGACGGGGTCGTTTTTCTC TGCGTTCAGTGGATTTCCGTCTTTTGGAAGTGGATTTTCTTCTTTTGATACAGGATTTACTTCATTTGGGTCACTAGGTCACGGGGGCCT CACTTCATTCTCTTCCACGTCATTTGGTGGTAGTGGCATGGGCAACTTCAAATCGATATCAACTTCAACTAAAATGGTTAATGGCAGAAA AATCACTACAAAGAGAATTGTCGAGAACGGTCAAGAAAGAGTAGAAGTTGAAGAAGATGGCCAGTTAAAGTCCTTAACAATAAATGGGAA GATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTCTGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCTGGCATGGG CACCTTCCAGCACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCCTGCCTGCTGCTGATCCAGCC TCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACTTTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTATCTCCCCGGACCAT CCACCTGACCATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAGCTGCCCGCCATTCTGCACAC CGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGGGTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCGGATGAGAG AGAGCCCACAGAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTCCTGTTTGCTGTGTATGATCA AAGCGCCACTGCCCTGCACTTCCTGGGCCGCGTGGCCAACCCGCTGAGCACAGCATGAGGCCAGGGCCCCAGAACACAGTGCCTGGCAAG GCCTCTGCCCCTGGCCTTTGAGGCAAAGGCCAGCAGCAGATAACAACCCCGGACAAATCAGCGATGTGTCACCCCCAGTCTCCCACCTTT TCTTCTAATGAGTCGACTTTGAGCTGGAAAGCAGCCGTTTCTCCTTGGTCTAAGTGTGCTGCATGGAGTGAGCAGTAGAAGCCTGCAGCG GCACAAATGCACCTCCCAGTTTGCTGGGTTTATTTTAGAGAATGGGGGTGGGGAGGCAAGAACCAGTGTTTAGCGCGGGACTACTGTTCC AAAAAGAATTCCAACCGACCAGCTTGTTTGTGAAACAAAAAAGTGTTCCCTTTTCAAGTTGAGAACAAAAATTGGGTTTTAAAATTAAAG TATACATTTTTGCATTGCCTTCGGTTTGTATTTAGTGTCTTGAATGTAAGAACATGACCTCCGTGTAGTGTCTGTAATACCTTAGTTTTT TCCACAGATGCTTGTGATTTTTGAACAATACGTGAAAGATGCAAGCACCTGAATTTCTGTTTGAATGCGGAACCATAGCTGGTTATTTCT >In-frame_DNAJB6_ENST00000452797_chr7_157178305_+_AGT_ENST00000366667_chr1_230841946_-_1956nt GGAGAAAGGAGAGAAAGGAAAGCGCGAGGAGCCGCCGCCACCACCAGCGCAGCAGTCCTGGAGCTGTGAGGAGATTCGGGCCGTCACCCT GCCTCCCCTGCGTCCCGCCACCGGCCGCTTCTGTCCTCGGACCCATTCCAACAATCTCGTAAAACATGGTGGATTACTATGAAGTTCTAG GCGTGCAGAGACATGCCTCACCCGAGGATATTAAAAAGGCCTAAGAAACGGGACATCTATGACAAATATGGCAAAGAAGGATTAAATGGT GGAGGAGGAGGTGGAAGTCATTTTGACAGTCCATTTGAATTTGGCTTCACATTCCGTAACCCAGATGATGTCTTCAGGGAATTTTTTGGT GGAAGGGACCCATTTTCATTTGACTTCTTTGAAGACCCTTTTGAGGACTTCTTTGGGAATCGAAGGGGTCCCCGAGGAAGCAGAAGCCGA GGGACGGGGTCGTTTTTCTCTGCGTTCAGTGGATTTCCGTCTTTTGGAAGTGGATTTTCTTCTTTTGATACAGGATTTACTTCATTTGGG TCACTAGGTCACGGGGGCCTCACTTCATTCTCTTCCACGTCATTTGGTGGTAGTGGCATGGGCAACTTCAAATCGATATCAACTTCAACT AAAATGGTTAATGGCAGAAAAATCACTACAAAGAGAATTGTCGAGAACGGTCAAGAAAGAGTAGAAGTTGAAGAAGATGGCCAGTTAAAG TCCTTAACAATAAATGGGAAGATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTCTGGGTGGACAACAGCACCTCAGTGTCTGTT CCCATGCTCTCTGGCATGGGCACCTTCCAGCACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCC TGCCTGCTGCTGATCCAGCCTCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACTTTCCAGCAAAACTCCCTCAACTGGATGAAG AAACTATCTCCCCGGACCATCCACCTGACCATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAG CTGCCCGCCATTCTGCACACCGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGGGTGGGGGAGGTGCTGAACAGCATTTTTTTT GAGCTTGAAGCGGATGAGAGAGAGCCCACAGAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTC CTGTTTGCTGTGTATGATCAAAGCGCCACTGCCCTGCACTTCCTGGGCCGCGTGGCCAACCCGCTGAGCACAGCATGAGGCCAGGGCCCC AGAACACAGTGCCTGGCAAGGCCTCTGCCCCTGGCCTTTGAGGCAAAGGCCAGCAGCAGATAACAACCCCGGACAAATCAGCGATGTGTC ACCCCCAGTCTCCCACCTTTTCTTCTAATGAGTCGACTTTGAGCTGGAAAGCAGCCGTTTCTCCTTGGTCTAAGTGTGCTGCATGGAGTG AGCAGTAGAAGCCTGCAGCGGCACAAATGCACCTCCCAGTTTGCTGGGTTTATTTTAGAGAATGGGGGTGGGGAGGCAAGAACCAGTGTT TAGCGCGGGACTACTGTTCCAAAAAGAATTCCAACCGACCAGCTTGTTTGTGAAACAAAAAAGTGTTCCCTTTTCAAGTTGAGAACAAAA ATTGGGTTTTAAAATTAAAGTATACATTTTTGCATTGCCTTCGGTTTGTATTTAGTGTCTTGAATGTAAGAACATGACCTCCGTGTAGTG TCTGTAATACCTTAGTTTTTTCCACAGATGCTTGTGATTTTTGAACAATACGTGAAAGATGCAAGCACCTGAATTTCTGTTTGAATGCGG |
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FusionGenePPI for DNAJB6_AGT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DNAJB6 | KRT18, HDAC4, HDAC6, SIRT2, TP53, TP63, TP73, ALKBH1, UBC, MYC, PIK3CA, CUL3, CUL2, BRMS1, APP, SOX2, HDAC11, POLR1D, TARDBP, BAG1, BAG2, BAG3, BAG4, FKBP5, HSPA8, MLF2, STIP1, STUB1, FAM96A, FAM96B, HSPA1A, HSPA6, MAP3K1, MLF1, DNAJB2, C12orf45, HSPB8, NTRK1, CEP164, DYNLT1, XPO1, S100A4, MATR3, ESRRB, ZNF746, CYLD, TRIM25, ESR1 | AGT | EWSR1, GRB2, TP53, ITSN2, ACE, ACE2, ECE1, MME, GSDMB, REN, ATP6AP2, RIPK4, NDUFA3, CANX, HSPA5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJB6_AGT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | AGT | P01019 | DB01593 | Zinc | Angiotensinogen | small molecule | approved|investigational |
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RelatedDiseases for DNAJB6_AGT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DNAJB6 | C3148763 | MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1E | 2 | ORPHANET;UNIPROT |
| Hgene | DNAJB6 | C0686353 | Muscular Dystrophies, Limb-Girdle | 1 | CTD_human |
| Tgene | AGT | C0020538 | Hypertensive disease | 69 | CTD_human |
| Tgene | AGT | C0018800 | Cardiomegaly | 18 | CTD_human |
| Tgene | AGT | C0020564 | Hypertrophy | 6 | CTD_human |
| Tgene | AGT | C0149721 | Left Ventricular Hypertrophy | 6 | CTD_human |
| Tgene | AGT | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | AGT | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | AGT | C0033687 | Proteinuria | 5 | CTD_human |
| Tgene | AGT | C0016059 | Fibrosis | 4 | CTD_human |
| Tgene | AGT | C0022658 | Kidney Diseases | 4 | CTD_human |
| Tgene | AGT | C0162871 | Aortic Aneurysm, Abdominal | 4 | CTD_human |
| Tgene | AGT | C0553980 | Endomyocardial Fibrosis | 4 | CTD_human |
| Tgene | AGT | C0001925 | Albuminuria | 3 | CTD_human |
| Tgene | AGT | C0011853 | Diabetes Mellitus, Experimental | 3 | CTD_human |
| Tgene | AGT | C0018801 | Heart failure | 3 | CTD_human |
| Tgene | AGT | C0020649 | Hypotension | 3 | CTD_human;HPO |
| Tgene | AGT | C0021368 | Inflammation | 3 | CTD_human |
| Tgene | AGT | C0003811 | Cardiac Arrhythmia | 2 | CTD_human |
| Tgene | AGT | C0004153 | Atherosclerosis | 2 | CTD_human |
| Tgene | AGT | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | AGT | C0011881 | Diabetic Nephropathy | 2 | CTD_human |
| Tgene | AGT | C0027051 | Myocardial Infarction | 2 | CTD_human |
| Tgene | AGT | C0027055 | Myocardial Reperfusion Injury | 2 | CTD_human |
| Tgene | AGT | C0027540 | Necrosis | 2 | CTD_human |
| Tgene | AGT | C0266313 | Allanson Pantzar McLeod syndrome | 2 | CTD_human;HPO;ORPHANET;UNIPROT |
| Tgene | AGT | C0002063 | Alkalosis | 1 | CTD_human |
| Tgene | AGT | C0002871 | Anemia | 1 | CTD_human |
| Tgene | AGT | C0002949 | Aneurysm, Dissecting | 1 | CTD_human |
| Tgene | AGT | C0003460 | Anuria | 1 | CTD_human;HPO |
| Tgene | AGT | C0003486 | Aortic Aneurysm | 1 | CTD_human |
| Tgene | AGT | C0007192 | Cardiomyopathy, Alcoholic | 1 | CTD_human |
| Tgene | AGT | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| Tgene | AGT | C0007273 | Carotid Artery Diseases | 1 | CTD_human |
| Tgene | AGT | C0007370 | Catalepsy | 1 | CTD_human |
| Tgene | AGT | C0009241 | Cognition Disorders | 1 | CTD_human |
| Tgene | AGT | C0011071 | Sudden death | 1 | CTD_human |
| Tgene | AGT | C0011884 | Diabetic Retinopathy | 1 | CTD_human |
| Tgene | AGT | C0015934 | Fetal Growth Retardation | 1 | CTD_human |
| Tgene | AGT | C0017658 | Glomerulonephritis | 1 | CTD_human |
| Tgene | AGT | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| Tgene | AGT | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
| Tgene | AGT | C0018799 | Heart Diseases | 1 | CTD_human |
| Tgene | AGT | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| Tgene | AGT | C0020429 | Hyperalgesia | 1 | CTD_human |
| Tgene | AGT | C0020452 | Hyperemia | 1 | CTD_human |
| Tgene | AGT | C0020540 | Malignant Hypertension | 1 | CTD_human |
| Tgene | AGT | C0020544 | Renal hypertension | 1 | CTD_human |
| Tgene | AGT | C0020621 | Hypokalemia | 1 | CTD_human |
| Tgene | AGT | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Tgene | AGT | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | AGT | C0027720 | Nephrosis | 1 | CTD_human |
| Tgene | AGT | C0029944 | Drug Overdose | 1 | CTD_human |
| Tgene | AGT | C0030922 | Peptic Ulcer Hemorrhage | 1 | CTD_human |
| Tgene | AGT | C0032914 | Pre-Eclampsia | 1 | CTD_human |
| Tgene | AGT | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Tgene | AGT | C0035344 | Retinopathy of Prematurity | 1 | CTD_human |
| Tgene | AGT | C0036572 | Seizures | 1 | CTD_human |
| Tgene | AGT | C0040053 | Thrombosis | 1 | CTD_human |
| Tgene | AGT | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | AGT | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
| Tgene | AGT | C0243050 | Cardiovascular Abnormalities | 1 | CTD_human |
| Tgene | AGT | C0428977 | Bradycardia | 1 | CTD_human |
| Tgene | AGT | C0878544 | Cardiomyopathies | 1 | CTD_human |
| Tgene | AGT | C1565489 | Renal Insufficiency | 1 | CTD_human |
| Tgene | AGT | C2936380 | Neointima | 1 | CTD_human |
| Tgene | AGT | C3850148 | Vascular Remodeling | 1 | CTD_human |
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