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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10207

FusionGeneSummary for DNAJA4_FOXK2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJA4_FOXK2
Fusion gene ID: 10207
HgeneTgene
Gene symbol

DNAJA4

FOXK2

Gene ID

55466

3607

Gene nameDnaJ heat shock protein family (Hsp40) member A4forkhead box K2
SynonymsMST104|MSTP104|PRO1472ILF|ILF-1|ILF1
Cytomap

15q25.1

17q25.3

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily A member 4DnaJ (Hsp40) homolog, subfamily A, member 4forkhead box protein K2FOXK1cellular transcription factor ILF-1interleukin enhancer-binding factor 1
Modification date2018052320180523
UniProtAcc

Q8WW22

Q01167

Ensembl transtripts involved in fusion geneENST00000394855, ENST00000489435, 
ENST00000343789, ENST00000394852, 
ENST00000446172, 
ENST00000335255, 
ENST00000529652, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 6 X 4=120
# samples 47
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJA4 [Title/Abstract] AND FOXK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJA4

GO:0042026

protein refolding

21231916

HgeneDNAJA4

GO:0090084

negative regulation of inclusion body assembly

21231916

TgeneFOXK2

GO:0045944

positive regulation of transcription by RNA polymerase II

9065434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1X60787DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
ChiTaRS3.1M94654DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000394855ENST00000335255DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
5CDS-intronENST00000394855ENST00000529652DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
intron-3CDSENST00000489435ENST00000335255DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
intron-intronENST00000489435ENST00000529652DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
Frame-shiftENST00000343789ENST00000335255DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
5CDS-intronENST00000343789ENST00000529652DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
Frame-shiftENST00000394852ENST00000335255DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
5CDS-intronENST00000394852ENST00000529652DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
Frame-shiftENST00000446172ENST00000335255DNAJA4chr15

78572693

+FOXK2chr17

80478124

+
5CDS-intronENST00000446172ENST00000529652DNAJA4chr15

78572693

+FOXK2chr17

80478124

+

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FusionProtFeatures for DNAJA4_FOXK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJA4

Q8WW22

FOXK2

Q01167

Transcriptional regulator that recognizes the coresequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) inthe IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus(PubMed:25805136). Also binds to HIV-1 long terminal repeat. Maybe involved in both positive and negative regulation of importantviral and cellular promoter elements (PubMed:1909027).{ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027,ECO:0000269|PubMed:25805136}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJA4_FOXK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJA4_FOXK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJA4_FOXK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJA4_FOXK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource