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Fusion gene ID: 10207 |
FusionGeneSummary for DNAJA4_FOXK2 |
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Fusion gene information | Fusion gene name: DNAJA4_FOXK2 | Fusion gene ID: 10207 | Hgene | Tgene | Gene symbol | DNAJA4 | FOXK2 | Gene ID | 55466 | 3607 |
Gene name | DnaJ heat shock protein family (Hsp40) member A4 | forkhead box K2 | |
Synonyms | MST104|MSTP104|PRO1472 | ILF|ILF-1|ILF1 | |
Cytomap | 15q25.1 | 17q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily A member 4DnaJ (Hsp40) homolog, subfamily A, member 4 | forkhead box protein K2FOXK1cellular transcription factor ILF-1interleukin enhancer-binding factor 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8WW22 | Q01167 | |
Ensembl transtripts involved in fusion gene | ENST00000394855, ENST00000489435, ENST00000343789, ENST00000394852, ENST00000446172, | ENST00000335255, ENST00000529652, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 6 X 4=120 |
# samples | 4 | 7 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAJA4 [Title/Abstract] AND FOXK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DNAJA4 | GO:0042026 | protein refolding | 21231916 |
Hgene | DNAJA4 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
Tgene | FOXK2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9065434 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | X60787 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + | ||
ChiTaRS3.1 | M94654 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000394855 | ENST00000335255 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
5CDS-intron | ENST00000394855 | ENST00000529652 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
intron-3CDS | ENST00000489435 | ENST00000335255 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
intron-intron | ENST00000489435 | ENST00000529652 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
Frame-shift | ENST00000343789 | ENST00000335255 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
5CDS-intron | ENST00000343789 | ENST00000529652 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
Frame-shift | ENST00000394852 | ENST00000335255 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
5CDS-intron | ENST00000394852 | ENST00000529652 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
Frame-shift | ENST00000446172 | ENST00000335255 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
5CDS-intron | ENST00000446172 | ENST00000529652 | DNAJA4 | chr15 | 78572693 | + | FOXK2 | chr17 | 80478124 | + |
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FusionProtFeatures for DNAJA4_FOXK2 |
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Hgene | Tgene |
DNAJA4 | FOXK2 |
Transcriptional regulator that recognizes the coresequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) inthe IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus(PubMed:25805136). Also binds to HIV-1 long terminal repeat. Maybe involved in both positive and negative regulation of importantviral and cellular promoter elements (PubMed:1909027).{ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027,ECO:0000269|PubMed:25805136}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJA4_FOXK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJA4_FOXK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJA4_FOXK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJA4_FOXK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |