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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10206

FusionGeneSummary for DNAJA4_DNAJA4

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJA4_DNAJA4
Fusion gene ID: 10206
HgeneTgene
Gene symbol

DNAJA4

DNAJA4

Gene ID

55466

55466

Gene nameDnaJ heat shock protein family (Hsp40) member A4DnaJ heat shock protein family (Hsp40) member A4
SynonymsMST104|MSTP104|PRO1472MST104|MSTP104|PRO1472
Cytomap

15q25.1

15q25.1

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily A member 4DnaJ (Hsp40) homolog, subfamily A, member 4dnaJ homolog subfamily A member 4DnaJ (Hsp40) homolog, subfamily A, member 4
Modification date2018052320180523
UniProtAcc

Q8WW22

Q8WW22

Ensembl transtripts involved in fusion geneENST00000394855, ENST00000489435, 
ENST00000343789, ENST00000394852, 
ENST00000446172, 		ENST00000394855, 
ENST00000489435, ENST00000343789, 
ENST00000394852, ENST00000446172, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 41
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: DNAJA4 [Title/Abstract] AND DNAJA4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJA4

GO:0042026

protein refolding

21231916

HgeneDNAJA4

GO:0090084

negative regulation of inclusion body assembly

21231916

TgeneDNAJA4

GO:0042026

protein refolding

21231916

TgeneDNAJA4

GO:0090084

negative regulation of inclusion body assembly

21231916


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB851178DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000394855ENST00000394855DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394855ENST00000489435DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394855ENST00000343789DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394855ENST00000394852DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394855ENST00000446172DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000489435ENST00000394855DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000489435ENST00000489435DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000489435ENST00000343789DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000489435ENST00000394852DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000489435ENST00000446172DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000343789ENST00000394855DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000343789ENST00000489435DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000343789ENST00000343789DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000343789ENST00000394852DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000343789ENST00000446172DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394852ENST00000394855DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394852ENST00000489435DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394852ENST00000343789DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394852ENST00000394852DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000394852ENST00000446172DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000446172ENST00000394855DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000446172ENST00000489435DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000446172ENST00000343789DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000446172ENST00000394852DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+
intron-intronENST00000446172ENST00000446172DNAJA4chr15

78571525

-DNAJA4chr15

78571549

+

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FusionProtFeatures for DNAJA4_DNAJA4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJA4

Q8WW22

DNAJA4

Q8WW22


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJA4_DNAJA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJA4_DNAJA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJA4_DNAJA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJA4_DNAJA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource