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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10205

FusionGeneSummary for DNAJA4_CLIC4

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJA4_CLIC4
Fusion gene ID: 10205
HgeneTgene
Gene symbol

DNAJA4

CLIC4

Gene ID

55466

25932

Gene nameDnaJ heat shock protein family (Hsp40) member A4chloride intracellular channel 4
SynonymsMST104|MSTP104|PRO1472CLIC4L|H1|MTCLIC|huH1|p64H1
Cytomap

15q25.1

1p36.11

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily A member 4DnaJ (Hsp40) homolog, subfamily A, member 4chloride intracellular channel protein 4chloride intracellular channel 4 likeintracellular chloride ion channel protein p64H1
Modification date2018052320180523
UniProtAcc

Q8WW22

Q9Y696

Ensembl transtripts involved in fusion geneENST00000394855, ENST00000489435, 
ENST00000343789, ENST00000394852, 
ENST00000446172, 
ENST00000374379, 
ENST00000497755, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 4 X 4=80
# samples 45
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJA4 [Title/Abstract] AND CLIC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJA4

GO:0042026

protein refolding

21231916

HgeneDNAJA4

GO:0090084

negative regulation of inclusion body assembly

21231916

TgeneCLIC4

GO:0030336

negative regulation of cell migration

12163372


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D9-A1X3-06ADNAJA4chr15

78556735

+CLIC4chr1

25124233

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000394855ENST00000374379DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
5CDS-3UTRENST00000394855ENST00000497755DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
Frame-shiftENST00000489435ENST00000374379DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
5CDS-3UTRENST00000489435ENST00000497755DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
intron-3CDSENST00000343789ENST00000374379DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
intron-3UTRENST00000343789ENST00000497755DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
intron-3CDSENST00000394852ENST00000374379DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
intron-3UTRENST00000394852ENST00000497755DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
intron-3CDSENST00000446172ENST00000374379DNAJA4chr15

78556735

+CLIC4chr1

25124233

+
intron-3UTRENST00000446172ENST00000497755DNAJA4chr15

78556735

+CLIC4chr1

25124233

+

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FusionProtFeatures for DNAJA4_CLIC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJA4

Q8WW22

CLIC4

Q9Y696

Can insert into membranes and form poorly selective ionchannels that may also transport chloride ions. Channel activitydepends on the pH. Membrane insertion seems to be redox-regulatedand may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions likea potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.Could also promote endothelial cell proliferation and regulateendothelial morphogenesis (tubulogenesis).{ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596,ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224,ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJA4_CLIC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJA4_CLIC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNAJA4UBC, SH3BP4, ERG, ENDOG, DNAJA2, DNAJA1, TUBA1A, TUBB6, MLLT11, TIMM50, CXorf57, TUBB4A, PRPS1, BANP, HSPA1A, HSPA6, EIF3I, CCT2, CCT3, AHSA1, CAD, CCT4, CCT6A, CCT6B, GRPEL1, HSPA4, HSPA4L, HSPA8, HSPA9, HSPH1, PSMC2, PSMC6, HSPA5, HYOU1, KPNA2, PSMC5, PSMD11, XPO1, SORT1, SYNCRIP, SGTB, BAG6, HPSE, KIAA1161, TCTN2, BRCA1CLIC4CDK2, SPRTN, HNRNPA1, HSP90AB1, REL, CLIC2, CLIC6, CLIC5, TPRN, ACADS, CDA, CSK, EZR, FDPS, HADH, HIBCH, PSMA1, PSMA2, PSMA5, PSMB1, PSMB7, SHC1, SUGT1, TAGLN2, TAGLN3, TPD52, COASY, CRKL, DAG1, DDB1, DNAJC9, HNRNPH2, LSM3, NDRG1, P4HB, PDCD6, PSMA3, PSMB4, RABIF, SEPHS1, ST13, UBA2, NTRK1, ICAM1, TRIM25, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJA4_CLIC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJA4_CLIC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLIC4C0029408Degenerative polyarthritis1CTD_human
TgeneCLIC4C0033578Prostatic Neoplasms1CTD_human
TgeneCLIC4C0043094Weight Gain1CTD_human