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Fusion gene ID: 10205 |
FusionGeneSummary for DNAJA4_CLIC4 |
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Fusion gene information | Fusion gene name: DNAJA4_CLIC4 | Fusion gene ID: 10205 | Hgene | Tgene | Gene symbol | DNAJA4 | CLIC4 | Gene ID | 55466 | 25932 |
Gene name | DnaJ heat shock protein family (Hsp40) member A4 | chloride intracellular channel 4 | |
Synonyms | MST104|MSTP104|PRO1472 | CLIC4L|H1|MTCLIC|huH1|p64H1 | |
Cytomap | 15q25.1 | 1p36.11 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily A member 4DnaJ (Hsp40) homolog, subfamily A, member 4 | chloride intracellular channel protein 4chloride intracellular channel 4 likeintracellular chloride ion channel protein p64H1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8WW22 | Q9Y696 | |
Ensembl transtripts involved in fusion gene | ENST00000394855, ENST00000489435, ENST00000343789, ENST00000394852, ENST00000446172, | ENST00000374379, ENST00000497755, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 4 X 4=80 |
# samples | 4 | 5 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAJA4 [Title/Abstract] AND CLIC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DNAJA4 | GO:0042026 | protein refolding | 21231916 |
Hgene | DNAJA4 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
Tgene | CLIC4 | GO:0030336 | negative regulation of cell migration | 12163372 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-D9-A1X3-06A | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000394855 | ENST00000374379 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
5CDS-3UTR | ENST00000394855 | ENST00000497755 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
Frame-shift | ENST00000489435 | ENST00000374379 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
5CDS-3UTR | ENST00000489435 | ENST00000497755 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
intron-3CDS | ENST00000343789 | ENST00000374379 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
intron-3UTR | ENST00000343789 | ENST00000497755 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
intron-3CDS | ENST00000394852 | ENST00000374379 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
intron-3UTR | ENST00000394852 | ENST00000497755 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
intron-3CDS | ENST00000446172 | ENST00000374379 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
intron-3UTR | ENST00000446172 | ENST00000497755 | DNAJA4 | chr15 | 78556735 | + | CLIC4 | chr1 | 25124233 | + |
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FusionProtFeatures for DNAJA4_CLIC4 |
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Hgene | Tgene |
DNAJA4 | CLIC4 |
Can insert into membranes and form poorly selective ionchannels that may also transport chloride ions. Channel activitydepends on the pH. Membrane insertion seems to be redox-regulatedand may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions likea potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.Could also promote endothelial cell proliferation and regulateendothelial morphogenesis (tubulogenesis).{ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596,ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224,ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJA4_CLIC4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJA4_CLIC4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DNAJA4 | UBC, SH3BP4, ERG, ENDOG, DNAJA2, DNAJA1, TUBA1A, TUBB6, MLLT11, TIMM50, CXorf57, TUBB4A, PRPS1, BANP, HSPA1A, HSPA6, EIF3I, CCT2, CCT3, AHSA1, CAD, CCT4, CCT6A, CCT6B, GRPEL1, HSPA4, HSPA4L, HSPA8, HSPA9, HSPH1, PSMC2, PSMC6, HSPA5, HYOU1, KPNA2, PSMC5, PSMD11, XPO1, SORT1, SYNCRIP, SGTB, BAG6, HPSE, KIAA1161, TCTN2, BRCA1 | CLIC4 | CDK2, SPRTN, HNRNPA1, HSP90AB1, REL, CLIC2, CLIC6, CLIC5, TPRN, ACADS, CDA, CSK, EZR, FDPS, HADH, HIBCH, PSMA1, PSMA2, PSMA5, PSMB1, PSMB7, SHC1, SUGT1, TAGLN2, TAGLN3, TPD52, COASY, CRKL, DAG1, DDB1, DNAJC9, HNRNPH2, LSM3, NDRG1, P4HB, PDCD6, PSMA3, PSMB4, RABIF, SEPHS1, ST13, UBA2, NTRK1, ICAM1, TRIM25, G3BP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJA4_CLIC4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJA4_CLIC4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CLIC4 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | CLIC4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CLIC4 | C0043094 | Weight Gain | 1 | CTD_human |