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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10198

FusionGeneSummary for DNAJA2_ARID1A

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJA2_ARID1A
Fusion gene ID: 10198
HgeneTgene
Gene symbol

DNAJA2

ARID1A

Gene ID

10294

8289

Gene nameDnaJ heat shock protein family (Hsp40) member A2AT-rich interaction domain 1A
SynonymsCPR3|DJ3|DJA2|DNAJ|DNJ3|HIRIP4|PRO3015|RDJ2B120|BAF250|BAF250a|BM029|C1orf4|CSS2|ELD|MRD14|OSA1|P270|SMARCF1|hELD|hOSA1
Cytomap

16q11.2

1p36.11

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily A member 2DnaJ (Hsp40) homolog, subfamily A, member 2HIRA interacting protein 4cell cycle progression 3 proteincell cycle progression restoration gene 3 proteinrenal carcinoma antigen NY-REN-14AT-rich interactive domain-containing protein 1AARID domain-containing protein 1AAT rich interactive domain 1A (SWI-like)BRG1-associated factor 250aOSA1 nuclear proteinSWI-like proteinSWI/SNF complex protein p270SWI/SNF-related, matrix-associated,
Modification date2018052320180519
UniProtAcc

O60884

O14497

Ensembl transtripts involved in fusion geneENST00000317089, ENST00000324856, 
ENST00000457599, ENST00000374152, 
ENST00000540690, 
Fusion gene scores* DoF score5 X 5 X 2=507 X 11 X 3=231
# samples 611
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/231*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJA2 [Title/Abstract] AND ARID1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJA2

GO:0042026

protein refolding

21231916

TgeneARID1A

GO:0006337

nucleosome disassembly

8895581

TgeneARID1A

GO:0006338

chromatin remodeling

11726552

TgeneARID1A

GO:0030520

intracellular estrogen receptor signaling pathway

12200431

TgeneARID1A

GO:0030521

androgen receptor signaling pathway

12200431

TgeneARID1A

GO:0042921

glucocorticoid receptor signaling pathway

12200431

TgeneARID1A

GO:0045893

positive regulation of transcription, DNA-templated

12200431


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP213958DNAJA2chr16

46998637

-ARID1Achr1

27106115

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000317089ENST00000324856DNAJA2chr16

46998637

-ARID1Achr1

27106115

+
intron-3CDSENST00000317089ENST00000457599DNAJA2chr16

46998637

-ARID1Achr1

27106115

+
intron-3CDSENST00000317089ENST00000374152DNAJA2chr16

46998637

-ARID1Achr1

27106115

+
intron-3CDSENST00000317089ENST00000540690DNAJA2chr16

46998637

-ARID1Achr1

27106115

+

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FusionProtFeatures for DNAJA2_ARID1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJA2

O60884

ARID1A

O14497

Co-chaperone of Hsc70. Stimulates ATP hydrolysis and thefolding of unfolded proteins mediated by HSPA1A/B (in vitro)(PubMed:24318877). {ECO:0000269|PubMed:24318877}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJA2_ARID1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJA2_ARID1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJA2_ARID1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJA2_ARID1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARID1AC0038356Stomach Neoplasms3CTD_human
TgeneARID1AC2239176Liver carcinoma3CTD_human
TgeneARID1AC0001418Adenocarcinoma1CTD_human
TgeneARID1AC0005695Bladder Neoplasm1CTD_human
TgeneARID1AC0006413Burkitt Lymphoma1CTD_human
TgeneARID1AC0007138Carcinoma, Transitional Cell1CTD_human
TgeneARID1AC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneARID1AC0014170Endometrial Neoplasms1CTD_human
TgeneARID1AC0027819Neuroblastoma1CTD_human
TgeneARID1AC0036920Sezary Syndrome1CTD_human
TgeneARID1AC0079772T-Cell Lymphoma1CTD_human
TgeneARID1AC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneARID1AC0206698Cholangiocarcinoma1CTD_human
TgeneARID1AC0265338Coffin-Siris syndrome1CTD_human;ORPHANET
TgeneARID1AC0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneARID1AC0920269Microsatellite Instability1CTD_human
TgeneARID1AC2931822Nasopharyngeal carcinoma1CTD_human