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Fusion gene ID: 10198 |
FusionGeneSummary for DNAJA2_ARID1A |
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Fusion gene information | Fusion gene name: DNAJA2_ARID1A | Fusion gene ID: 10198 | Hgene | Tgene | Gene symbol | DNAJA2 | ARID1A | Gene ID | 10294 | 8289 |
Gene name | DnaJ heat shock protein family (Hsp40) member A2 | AT-rich interaction domain 1A | |
Synonyms | CPR3|DJ3|DJA2|DNAJ|DNJ3|HIRIP4|PRO3015|RDJ2 | B120|BAF250|BAF250a|BM029|C1orf4|CSS2|ELD|MRD14|OSA1|P270|SMARCF1|hELD|hOSA1 | |
Cytomap | 16q11.2 | 1p36.11 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily A member 2DnaJ (Hsp40) homolog, subfamily A, member 2HIRA interacting protein 4cell cycle progression 3 proteincell cycle progression restoration gene 3 proteinrenal carcinoma antigen NY-REN-14 | AT-rich interactive domain-containing protein 1AARID domain-containing protein 1AAT rich interactive domain 1A (SWI-like)BRG1-associated factor 250aOSA1 nuclear proteinSWI-like proteinSWI/SNF complex protein p270SWI/SNF-related, matrix-associated, | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O60884 | O14497 | |
Ensembl transtripts involved in fusion gene | ENST00000317089, | ENST00000324856, ENST00000457599, ENST00000374152, ENST00000540690, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 7 X 11 X 3=231 |
# samples | 6 | 11 | |
** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/231*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAJA2 [Title/Abstract] AND ARID1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DNAJA2 | GO:0042026 | protein refolding | 21231916 |
Tgene | ARID1A | GO:0006337 | nucleosome disassembly | 8895581 |
Tgene | ARID1A | GO:0006338 | chromatin remodeling | 11726552 |
Tgene | ARID1A | GO:0030520 | intracellular estrogen receptor signaling pathway | 12200431 |
Tgene | ARID1A | GO:0030521 | androgen receptor signaling pathway | 12200431 |
Tgene | ARID1A | GO:0042921 | glucocorticoid receptor signaling pathway | 12200431 |
Tgene | ARID1A | GO:0045893 | positive regulation of transcription, DNA-templated | 12200431 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP213958 | DNAJA2 | chr16 | 46998637 | - | ARID1A | chr1 | 27106115 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000317089 | ENST00000324856 | DNAJA2 | chr16 | 46998637 | - | ARID1A | chr1 | 27106115 | + |
intron-3CDS | ENST00000317089 | ENST00000457599 | DNAJA2 | chr16 | 46998637 | - | ARID1A | chr1 | 27106115 | + |
intron-3CDS | ENST00000317089 | ENST00000374152 | DNAJA2 | chr16 | 46998637 | - | ARID1A | chr1 | 27106115 | + |
intron-3CDS | ENST00000317089 | ENST00000540690 | DNAJA2 | chr16 | 46998637 | - | ARID1A | chr1 | 27106115 | + |
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FusionProtFeatures for DNAJA2_ARID1A |
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Hgene | Tgene |
DNAJA2 | ARID1A |
Co-chaperone of Hsc70. Stimulates ATP hydrolysis and thefolding of unfolded proteins mediated by HSPA1A/B (in vitro)(PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJA2_ARID1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJA2_ARID1A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJA2_ARID1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJA2_ARID1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ARID1A | C0038356 | Stomach Neoplasms | 3 | CTD_human |
Tgene | ARID1A | C2239176 | Liver carcinoma | 3 | CTD_human |
Tgene | ARID1A | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | ARID1A | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | ARID1A | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
Tgene | ARID1A | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Tgene | ARID1A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | ARID1A | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Tgene | ARID1A | C0027819 | Neuroblastoma | 1 | CTD_human |
Tgene | ARID1A | C0036920 | Sezary Syndrome | 1 | CTD_human |
Tgene | ARID1A | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
Tgene | ARID1A | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
Tgene | ARID1A | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Tgene | ARID1A | C0265338 | Coffin-Siris syndrome | 1 | CTD_human;ORPHANET |
Tgene | ARID1A | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
Tgene | ARID1A | C0920269 | Microsatellite Instability | 1 | CTD_human |
Tgene | ARID1A | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |