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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10197

FusionGeneSummary for DNAJA2_ANKRD11

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJA2_ANKRD11
Fusion gene ID: 10197
HgeneTgene
Gene symbol

DNAJA2

ANKRD11

Gene ID

10294

29123

Gene nameDnaJ heat shock protein family (Hsp40) member A2ankyrin repeat domain 11
SynonymsCPR3|DJ3|DJA2|DNAJ|DNJ3|HIRIP4|PRO3015|RDJ2ANCO-1|ANCO1|LZ16|T13
Cytomap

16q11.2

16q24.3

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily A member 2DnaJ (Hsp40) homolog, subfamily A, member 2HIRA interacting protein 4cell cycle progression 3 proteincell cycle progression restoration gene 3 proteinrenal carcinoma antigen NY-REN-14ankyrin repeat domain-containing protein 11ankyrin repeat-containing cofactor 1nasopharyngeal carcinoma susceptibility proteintruncated ankyrin repeat domain 11 aberrant transcript 1truncated ankyrin repeat domain 11 aberrant transcript 2
Modification date2018052320180523
UniProtAcc

O60884

Q6UB99

Ensembl transtripts involved in fusion geneENST00000317089, ENST00000378330, 
ENST00000301030, ENST00000563291, 
ENST00000567736, 
Fusion gene scores* DoF score5 X 5 X 2=5012 X 14 X 4=672
# samples 616
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(16/672*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJA2 [Title/Abstract] AND ANKRD11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJA2

GO:0042026

protein refolding

21231916


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF326211DNAJA2chr16

46990865

+ANKRD11chr16

89350945

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000317089ENST00000378330DNAJA2chr16

46990865

+ANKRD11chr16

89350945

-
intron-3CDSENST00000317089ENST00000301030DNAJA2chr16

46990865

+ANKRD11chr16

89350945

-
intron-intronENST00000317089ENST00000563291DNAJA2chr16

46990865

+ANKRD11chr16

89350945

-
intron-intronENST00000317089ENST00000567736DNAJA2chr16

46990865

+ANKRD11chr16

89350945

-

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FusionProtFeatures for DNAJA2_ANKRD11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJA2

O60884

ANKRD11

Q6UB99

Co-chaperone of Hsc70. Stimulates ATP hydrolysis and thefolding of unfolded proteins mediated by HSPA1A/B (in vitro)(PubMed:24318877). {ECO:0000269|PubMed:24318877}. Chromatin regulator which modulates histone acetylationand gene expression in neural precursor cells (By similarity). Mayrecruit histone deacetylases (HDACs) to the p160coactivators/nuclear receptor complex to inhibit ligand-dependenttransactivation (PubMed:15184363). Has a role in proliferation anddevelopment of cortical neural precursors (PubMed:25556659). Mayalso regulate bone homeostasis (By similarity).{ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363,ECO:0000269|PubMed:25556659}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJA2_ANKRD11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJA2_ANKRD11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJA2_ANKRD11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJA2_ANKRD11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneANKRD11C0005944Metabolic Bone Disorder1CTD_human
TgeneANKRD11C1510586Autism Spectrum Disorders1CTD_human