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Fusion gene ID: 10197 |
FusionGeneSummary for DNAJA2_ANKRD11 |
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Fusion gene information | Fusion gene name: DNAJA2_ANKRD11 | Fusion gene ID: 10197 | Hgene | Tgene | Gene symbol | DNAJA2 | ANKRD11 | Gene ID | 10294 | 29123 |
Gene name | DnaJ heat shock protein family (Hsp40) member A2 | ankyrin repeat domain 11 | |
Synonyms | CPR3|DJ3|DJA2|DNAJ|DNJ3|HIRIP4|PRO3015|RDJ2 | ANCO-1|ANCO1|LZ16|T13 | |
Cytomap | 16q11.2 | 16q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily A member 2DnaJ (Hsp40) homolog, subfamily A, member 2HIRA interacting protein 4cell cycle progression 3 proteincell cycle progression restoration gene 3 proteinrenal carcinoma antigen NY-REN-14 | ankyrin repeat domain-containing protein 11ankyrin repeat-containing cofactor 1nasopharyngeal carcinoma susceptibility proteintruncated ankyrin repeat domain 11 aberrant transcript 1truncated ankyrin repeat domain 11 aberrant transcript 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60884 | Q6UB99 | |
Ensembl transtripts involved in fusion gene | ENST00000317089, | ENST00000378330, ENST00000301030, ENST00000563291, ENST00000567736, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 12 X 14 X 4=672 |
# samples | 6 | 16 | |
** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(16/672*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAJA2 [Title/Abstract] AND ANKRD11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DNAJA2 | GO:0042026 | protein refolding | 21231916 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF326211 | DNAJA2 | chr16 | 46990865 | + | ANKRD11 | chr16 | 89350945 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000317089 | ENST00000378330 | DNAJA2 | chr16 | 46990865 | + | ANKRD11 | chr16 | 89350945 | - |
intron-3CDS | ENST00000317089 | ENST00000301030 | DNAJA2 | chr16 | 46990865 | + | ANKRD11 | chr16 | 89350945 | - |
intron-intron | ENST00000317089 | ENST00000563291 | DNAJA2 | chr16 | 46990865 | + | ANKRD11 | chr16 | 89350945 | - |
intron-intron | ENST00000317089 | ENST00000567736 | DNAJA2 | chr16 | 46990865 | + | ANKRD11 | chr16 | 89350945 | - |
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FusionProtFeatures for DNAJA2_ANKRD11 |
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Hgene | Tgene |
DNAJA2 | ANKRD11 |
Co-chaperone of Hsc70. Stimulates ATP hydrolysis and thefolding of unfolded proteins mediated by HSPA1A/B (in vitro)(PubMed:24318877). {ECO:0000269|PubMed:24318877}. | Chromatin regulator which modulates histone acetylationand gene expression in neural precursor cells (By similarity). Mayrecruit histone deacetylases (HDACs) to the p160coactivators/nuclear receptor complex to inhibit ligand-dependenttransactivation (PubMed:15184363). Has a role in proliferation anddevelopment of cortical neural precursors (PubMed:25556659). Mayalso regulate bone homeostasis (By similarity).{ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363,ECO:0000269|PubMed:25556659}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJA2_ANKRD11 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJA2_ANKRD11 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJA2_ANKRD11 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJA2_ANKRD11 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ANKRD11 | C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
Tgene | ANKRD11 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |