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Fusion gene ID: 10196 |
FusionGeneSummary for DNAJA1_GALNTL6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJA1_GALNTL6 | Fusion gene ID: 10196 | Hgene | Tgene | Gene symbol | DNAJA1 | GALNTL6 | Gene ID | 3301 | 442117 |
| Gene name | DnaJ heat shock protein family (Hsp40) member A1 | polypeptide N-acetylgalactosaminyltransferase like 6 | |
| Synonyms | DJ-2|DjA1|HDJ2|HSDJ|HSJ-2|HSJ2|HSPF4|NEDD7|hDJ-2 | GALNACT20|GALNT17|GalNAc-T6L | |
| Cytomap | 9p21.1 | 4q34.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily A member 1DnaJ (Hsp40) homolog, subfamily A, member 1dnaJ protein homolog 2heat shock 40 kDa protein 4heat shock protein J2heat shock protein, DNAJ-like 2human DnaJ protein 2neural precursor cell expressed, developmentally do | polypeptide N-acetylgalactosaminyltransferase-like 6GaNTase 17GalNAc transferase 17UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20UDP-N-acetyl-alpha-D-gala | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P31689 | Q49A17 | |
| Ensembl transtripts involved in fusion gene | ENST00000330899, ENST00000544625, ENST00000495015, | ENST00000506823, ENST00000508122, ENST00000457021, ENST00000511251, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 5 X 7=245 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DNAJA1 [Title/Abstract] AND GALNTL6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJA1 | GO:0031397 | negative regulation of protein ubiquitination | 12150907 |
| Hgene | DNAJA1 | GO:0051223 | regulation of protein transport | 14752510 |
| Hgene | DNAJA1 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion | 14752510 |
| Hgene | DNAJA1 | GO:1905259 | negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway | 14752510 |
| Tgene | GALNTL6 | GO:0018243 | protein O-linked glycosylation via threonine | 22186971 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-7477-01B | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000330899 | ENST00000506823 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| Frame-shift | ENST00000330899 | ENST00000508122 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| 5CDS-intron | ENST00000330899 | ENST00000457021 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| 5CDS-intron | ENST00000330899 | ENST00000511251 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| Frame-shift | ENST00000544625 | ENST00000506823 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| Frame-shift | ENST00000544625 | ENST00000508122 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| 5CDS-intron | ENST00000544625 | ENST00000457021 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| 5CDS-intron | ENST00000544625 | ENST00000511251 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| intron-3CDS | ENST00000495015 | ENST00000506823 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| intron-3CDS | ENST00000495015 | ENST00000508122 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| intron-intron | ENST00000495015 | ENST00000457021 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
| intron-intron | ENST00000495015 | ENST00000511251 | DNAJA1 | chr9 | 33030665 | + | GALNTL6 | chr4 | 173930329 | + |
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FusionProtFeatures for DNAJA1_GALNTL6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJA1 | GALNTL6 |
| Co-chaperone for HSPA8/Hsc70 (PubMed:10816573).Stimulates ATP hydrolysis, but not the folding of unfoldedproteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays arole in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negativelyregulates the translocation of BAX from the cytosol tomitochondria in response to cellular stress, thereby protectingcells against apoptosis (PubMed:14752510). Promotes apoptosis inresponse to cellular stress mediated by exposure to anisomycin orUV (PubMed:24512202). {ECO:0000269|PubMed:10816573,ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877,ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}. | Catalyzes the initial reaction in O-linkedoligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on theprotein receptor. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJA1_GALNTL6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJA1_GALNTL6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DNAJA1 | OSGEP, UQCRC1, ARL4D, CD58, TM4SF1, NELFCD, HSPA8, CFTR, PTTG1, PARK2, GPR37, SRRM2, SRRM1, UBC, AGO3, AGO4, HDAC5, PSMA3, CAV2, NUDT3, BCS1L, HMGCL, PCK1, VHL, HDGF, SIRT7, FBXO25, ERG, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, LRRK1, LRRK2, HTT, UBASH3B, SHC1, PACRG, HSPA9, TPP1, PSAP, SPTAN1, TRA2B, KCNH2, BRCA1, PAXIP1, YWHAE, KCNQ4, IQCB1, HSP90AA1, NOS2, METTL21B, METTL23, PAN2, NPM1, SOX2, HDAC2, HDAC6, HDAC10, HDAC11, EGFR, HIVEP1, CDC16, LSM2, FBXO6, AIMP1, EEF1B2, RARS, EEF1E1, EIF2S3, IQGAP1, QARS, RPLP0, ASB5, DNAJA4, NUDC, TP53, HUWE1, PCSK9, HSPA1A, HSPA6, OBSL1, SUZ12, AATK, ARAF, ILK, IRAK1, LIMK2, RAF1, HERC2, ENDOG, OSBPL11, OSBPL9, PLD2, UQCRQ, CCNJL, FRMD5, LLGL2, NF2, RPS6KB2, NTRK1, ACADM, AHSA1, CANX, CCT2, CCT3, CLGN, CAD, CCT6A, CCT6B, HSPA4, HSPA4L, HSPH1, PPP4R2, PSMC2, FAF1, HSPA5, HYOU1, KPNA4, LDHB, PRKCSH, PSMC5, PSMC6, PSMD11, USO1, PTEN, OFD1, MKS1, CEP44, RPGR, STIL, XRCC3, TUBA1C, RNF207, CRY1, GLIS3, MCM2, SNW1, CDC5L, EID1, OTUB1, ERBB3, ESRRB, NFATC2, PGR, CDC73, WWP2, MTMR11, CYLD, DLD, DNM1L, PDHA1, FOXA1, TRIM25, G3BP1, CCND2, UBE2A, TES | GALNTL6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJA1_GALNTL6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJA1_GALNTL6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DNAJA1 | C0026636 | Mouth Diseases | 1 | CTD_human |
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