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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10190

FusionGeneSummary for DNAH6_CHD6

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH6_CHD6
Fusion gene ID: 10190
HgeneTgene
Gene symbol

DNAH6

CHD6

Gene ID

1768

84181

Gene namedynein axonemal heavy chain 6chromodomain helicase DNA binding protein 6
SynonymsDNHL1|Dnahc6|HL-2|HL2CHD-6|CHD5|RIGB
Cytomap

2p11.2

20q12

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 6, axonemalaxonemal beta dynein heavy chain 6ciliary dynein heavy chain 6dynein heavy chain-like 1dynein, axonemal, heavy polypeptide 6chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein
Modification date2018052320180519
UniProtAcc

Q9C0G6

Q8TD26

Ensembl transtripts involved in fusion geneENST00000389394, ENST00000237449, 
ENST00000398278, ENST00000468661, 
ENST00000602588, 
ENST00000373233, 
ENST00000309279, ENST00000373222, 
ENST00000480022, 
Fusion gene scores* DoF score2 X 2 X 1=48 X 9 X 4=288
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAH6 [Title/Abstract] AND CHD6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF367299DNAH6chr2

84916104

+CHD6chr20

40242559

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000389394ENST00000373233DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000389394ENST00000309279DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000389394ENST00000373222DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000389394ENST00000480022DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000237449ENST00000373233DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000237449ENST00000309279DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000237449ENST00000373222DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000237449ENST00000480022DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000398278ENST00000373233DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000398278ENST00000309279DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000398278ENST00000373222DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000398278ENST00000480022DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000468661ENST00000373233DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000468661ENST00000309279DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000468661ENST00000373222DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000468661ENST00000480022DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000602588ENST00000373233DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000602588ENST00000309279DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000602588ENST00000373222DNAH6chr2

84916104

+CHD6chr20

40242559

-
intron-intronENST00000602588ENST00000480022DNAH6chr2

84916104

+CHD6chr20

40242559

-

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FusionProtFeatures for DNAH6_CHD6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH6

Q9C0G6

CHD6

Q8TD26


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAH6_CHD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAH6_CHD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAH6_CHD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAH6_CHD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHD6C0005695Bladder Neoplasm1CTD_human
TgeneCHD6C0007138Carcinoma, Transitional Cell1CTD_human
TgeneCHD6C0027819Neuroblastoma1CTD_human