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Fusion gene ID: 10190 |
FusionGeneSummary for DNAH6_CHD6 |
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Fusion gene information | Fusion gene name: DNAH6_CHD6 | Fusion gene ID: 10190 | Hgene | Tgene | Gene symbol | DNAH6 | CHD6 | Gene ID | 1768 | 84181 |
Gene name | dynein axonemal heavy chain 6 | chromodomain helicase DNA binding protein 6 | |
Synonyms | DNHL1|Dnahc6|HL-2|HL2 | CHD-6|CHD5|RIGB | |
Cytomap | 2p11.2 | 20q12 | |
Type of gene | protein-coding | protein-coding | |
Description | dynein heavy chain 6, axonemalaxonemal beta dynein heavy chain 6ciliary dynein heavy chain 6dynein heavy chain-like 1dynein, axonemal, heavy polypeptide 6 | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9C0G6 | Q8TD26 | |
Ensembl transtripts involved in fusion gene | ENST00000389394, ENST00000237449, ENST00000398278, ENST00000468661, ENST00000602588, | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 8 X 9 X 4=288 |
# samples | 2 | 10 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAH6 [Title/Abstract] AND CHD6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF367299 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000389394 | ENST00000373233 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000389394 | ENST00000309279 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000389394 | ENST00000373222 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000389394 | ENST00000480022 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000237449 | ENST00000373233 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000237449 | ENST00000309279 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000237449 | ENST00000373222 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000237449 | ENST00000480022 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000398278 | ENST00000373233 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000398278 | ENST00000309279 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000398278 | ENST00000373222 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000398278 | ENST00000480022 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000468661 | ENST00000373233 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000468661 | ENST00000309279 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000468661 | ENST00000373222 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000468661 | ENST00000480022 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000602588 | ENST00000373233 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000602588 | ENST00000309279 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000602588 | ENST00000373222 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
intron-intron | ENST00000602588 | ENST00000480022 | DNAH6 | chr2 | 84916104 | + | CHD6 | chr20 | 40242559 | - |
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FusionProtFeatures for DNAH6_CHD6 |
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Hgene | Tgene |
DNAH6 | CHD6 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAH6_CHD6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAH6_CHD6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAH6_CHD6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAH6_CHD6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CHD6 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | CHD6 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Tgene | CHD6 | C0027819 | Neuroblastoma | 1 | CTD_human |