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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10181

FusionGeneSummary for DNAH14_HDLBP

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH14_HDLBP
Fusion gene ID: 10181
HgeneTgene
Gene symbol

DNAH14

HDLBP

Gene ID

127602

3069

Gene namedynein axonemal heavy chain 14high density lipoprotein binding protein
SynonymsC1orf67|Dnahc14|HL-18|HL18HBP|PRO2900|VGL
Cytomap

1q42.12

2q37.3

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 14, axonemalaxonemal beta dynein heavy chain 14ciliary dynein heavy chain 14dynein, axonemal, heavy polypeptide 14vigilinHDL-binding protein
Modification date2018052320180522
UniProtAcc

Q0VDD8

Q00341

Ensembl transtripts involved in fusion geneENST00000445597, ENST00000430092, 
ENST00000439375, ENST00000400952, 
ENST00000366849, ENST00000366850, 
ENST00000498360, ENST00000366848, 
ENST00000391976, ENST00000310931, 
ENST00000391975, ENST00000427183, 
ENST00000476807, 
Fusion gene scores* DoF score4 X 3 X 4=4815 X 14 X 6=1260
# samples 416
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAH14 [Title/Abstract] AND HDLBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG984033DNAH14chr1

225581776

+HDLBPchr2

242194545

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000445597ENST00000391976DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000445597ENST00000310931DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000445597ENST00000391975DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000445597ENST00000427183DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-intronENST00000445597ENST00000476807DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000430092ENST00000391976DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000430092ENST00000310931DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000430092ENST00000391975DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000430092ENST00000427183DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-intronENST00000430092ENST00000476807DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000439375ENST00000391976DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000439375ENST00000310931DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000439375ENST00000391975DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000439375ENST00000427183DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-intronENST00000439375ENST00000476807DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000400952ENST00000391976DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000400952ENST00000310931DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000400952ENST00000391975DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000400952ENST00000427183DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-intronENST00000400952ENST00000476807DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366849ENST00000391976DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366849ENST00000310931DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366849ENST00000391975DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366849ENST00000427183DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-intronENST00000366849ENST00000476807DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366850ENST00000391976DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366850ENST00000310931DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366850ENST00000391975DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366850ENST00000427183DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-intronENST00000366850ENST00000476807DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000498360ENST00000391976DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000498360ENST00000310931DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000498360ENST00000391975DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000498360ENST00000427183DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-intronENST00000498360ENST00000476807DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366848ENST00000391976DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366848ENST00000310931DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366848ENST00000391975DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-3CDSENST00000366848ENST00000427183DNAH14chr1

225581776

+HDLBPchr2

242194545

-
intron-intronENST00000366848ENST00000476807DNAH14chr1

225581776

+HDLBPchr2

242194545

-

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FusionProtFeatures for DNAH14_HDLBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH14

Q0VDD8

HDLBP

Q00341

Appears to play a role in cell sterol metabolism. It mayfunction to protect cells from over-accumulation of cholesterol.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAH14_HDLBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAH14_HDLBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAH14_HDLBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAH14_HDLBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHDLBPC0004352Autistic Disorder1CTD_human
TgeneHDLBPC2931817Chromosome 2q37 deletion syndrome1CTD_human