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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10175

FusionGeneSummary for DNAH11_VDAC3

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH11_VDAC3
Fusion gene ID: 10175
HgeneTgene
Gene symbol

DNAH11

VDAC3

Gene ID

8701

7419

Gene namedynein axonemal heavy chain 11voltage dependent anion channel 3
SynonymsCILD7|DNAHBL|DNAHC11|DNHBL|DPL11HD-VDAC3|VDAC-3
Cytomap

7p15.3

8p11.21

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11voltage-dependent anion-selective channel protein 3outer mitochondrial membrane protein porin 3
Modification date2018052320180520
UniProtAcc

Q96DT5

Q9Y277

Ensembl transtripts involved in fusion geneENST00000409508, ENST00000328843, 
ENST00000465593, 
ENST00000392935, 
ENST00000522572, ENST00000521158, 
ENST00000022615, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 3 X 3=36
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNAH11 [Title/Abstract] AND VDAC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-B0-4945-01ADNAH11chr7

21584767

+VDAC3chr8

42251363

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000409508ENST00000392935DNAH11chr7

21584767

+VDAC3chr8

42251363

+
5CDS-5UTRENST00000409508ENST00000522572DNAH11chr7

21584767

+VDAC3chr8

42251363

+
5CDS-5UTRENST00000409508ENST00000521158DNAH11chr7

21584767

+VDAC3chr8

42251363

+
5CDS-5UTRENST00000409508ENST00000022615DNAH11chr7

21584767

+VDAC3chr8

42251363

+
5CDS-5UTRENST00000328843ENST00000392935DNAH11chr7

21584767

+VDAC3chr8

42251363

+
5CDS-5UTRENST00000328843ENST00000522572DNAH11chr7

21584767

+VDAC3chr8

42251363

+
5CDS-5UTRENST00000328843ENST00000521158DNAH11chr7

21584767

+VDAC3chr8

42251363

+
5CDS-5UTRENST00000328843ENST00000022615DNAH11chr7

21584767

+VDAC3chr8

42251363

+
intron-5UTRENST00000465593ENST00000392935DNAH11chr7

21584767

+VDAC3chr8

42251363

+
intron-5UTRENST00000465593ENST00000522572DNAH11chr7

21584767

+VDAC3chr8

42251363

+
intron-5UTRENST00000465593ENST00000521158DNAH11chr7

21584767

+VDAC3chr8

42251363

+
intron-5UTRENST00000465593ENST00000022615DNAH11chr7

21584767

+VDAC3chr8

42251363

+

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FusionProtFeatures for DNAH11_VDAC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH11

Q96DT5

VDAC3

Q9Y277

Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. Forms a channel through the mitochondrial outer membranethat allows diffusion of small hydrophilic molecules.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAH11_VDAC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAH11_VDAC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNAH11ZDHHC17VDAC3CASP4, DDX24, UBC, ICT1, CD4, PARK2, PPIF, VDAC1, UBA52, VDAC2, SUGP1, CDV3, SARNP, PQBP1, RBM27, THY1, SCO2, SRPRB, SF1, SCP2, ATP6V1H, ABCC1, VAPB, EIF4A1, MRPL53, VAPA, TKT, SERPINH1, TMEM256, NDUFA7, LAMTOR3, PIN4, YME1L1, SF3B4, ACAA1, SBDS, ATF2, FBXO6, OBSL1, RNF2, FAF2, ABCE1, RIC3, LYPD3, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5H, ATP5I, ATP5O, ATP6V0D1, ATP6V1A, BCAP31, CISD1, CISD2, CLTC, COX4I1, COX5A, DDOST, ILVBL, IMMT, MAGT1, NDUFA9, NDUFB7, NDUFB8, NDUFS4, NDUFS8, PHB, PHB2, RPN1, SGPL1, SSR1, SSR3, STX12, STX7, TECR, TOMM22, TOMM40, TSPO, ABCC3, ATP1A1, ATP1B3, ATP5F1, CYC1, JAGN1, MTCH1, MTCH2, COX2, RPLP0, SDHB, SLC25A11, SLC25A3, TMX1, NTRK1, UBXN8, OTUB1, DUSP23, APOE, SRC, HRAS, CD97, ERICH5, FAM8A1, SPATA19, RAP2A, TPTE, STOM, COX15, SOAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAH11_VDAC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAH11_VDAC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNAH11C0010068Coronary heart disease1CTD_human
HgeneDNAH11C0043094Weight Gain1CTD_human
HgeneDNAH11C0242339Dyslipidemias1CTD_human
HgeneDNAH11C2678473CILIARY DYSKINESIA, PRIMARY, 7 (disorder)1CTD_human;UNIPROT