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Fusion gene ID: 10175 |
FusionGeneSummary for DNAH11_VDAC3 |
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Fusion gene information | Fusion gene name: DNAH11_VDAC3 | Fusion gene ID: 10175 | Hgene | Tgene | Gene symbol | DNAH11 | VDAC3 | Gene ID | 8701 | 7419 |
Gene name | dynein axonemal heavy chain 11 | voltage dependent anion channel 3 | |
Synonyms | CILD7|DNAHBL|DNAHC11|DNHBL|DPL11 | HD-VDAC3|VDAC-3 | |
Cytomap | 7p15.3 | 8p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | dynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11 | voltage-dependent anion-selective channel protein 3outer mitochondrial membrane protein porin 3 | |
Modification date | 20180523 | 20180520 | |
UniProtAcc | Q96DT5 | Q9Y277 | |
Ensembl transtripts involved in fusion gene | ENST00000409508, ENST00000328843, ENST00000465593, | ENST00000392935, ENST00000522572, ENST00000521158, ENST00000022615, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 3 X 3=36 |
# samples | 4 | 5 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DNAH11 [Title/Abstract] AND VDAC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | KIRC | TCGA-B0-4945-01A | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000409508 | ENST00000392935 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
5CDS-5UTR | ENST00000409508 | ENST00000522572 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
5CDS-5UTR | ENST00000409508 | ENST00000521158 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
5CDS-5UTR | ENST00000409508 | ENST00000022615 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
5CDS-5UTR | ENST00000328843 | ENST00000392935 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
5CDS-5UTR | ENST00000328843 | ENST00000522572 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
5CDS-5UTR | ENST00000328843 | ENST00000521158 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
5CDS-5UTR | ENST00000328843 | ENST00000022615 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
intron-5UTR | ENST00000465593 | ENST00000392935 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
intron-5UTR | ENST00000465593 | ENST00000522572 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
intron-5UTR | ENST00000465593 | ENST00000521158 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
intron-5UTR | ENST00000465593 | ENST00000022615 | DNAH11 | chr7 | 21584767 | + | VDAC3 | chr8 | 42251363 | + |
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FusionProtFeatures for DNAH11_VDAC3 |
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Hgene | Tgene |
DNAH11 | VDAC3 |
Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. | Forms a channel through the mitochondrial outer membranethat allows diffusion of small hydrophilic molecules.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAH11_VDAC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAH11_VDAC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DNAH11 | ZDHHC17 | VDAC3 | CASP4, DDX24, UBC, ICT1, CD4, PARK2, PPIF, VDAC1, UBA52, VDAC2, SUGP1, CDV3, SARNP, PQBP1, RBM27, THY1, SCO2, SRPRB, SF1, SCP2, ATP6V1H, ABCC1, VAPB, EIF4A1, MRPL53, VAPA, TKT, SERPINH1, TMEM256, NDUFA7, LAMTOR3, PIN4, YME1L1, SF3B4, ACAA1, SBDS, ATF2, FBXO6, OBSL1, RNF2, FAF2, ABCE1, RIC3, LYPD3, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5H, ATP5I, ATP5O, ATP6V0D1, ATP6V1A, BCAP31, CISD1, CISD2, CLTC, COX4I1, COX5A, DDOST, ILVBL, IMMT, MAGT1, NDUFA9, NDUFB7, NDUFB8, NDUFS4, NDUFS8, PHB, PHB2, RPN1, SGPL1, SSR1, SSR3, STX12, STX7, TECR, TOMM22, TOMM40, TSPO, ABCC3, ATP1A1, ATP1B3, ATP5F1, CYC1, JAGN1, MTCH1, MTCH2, COX2, RPLP0, SDHB, SLC25A11, SLC25A3, TMX1, NTRK1, UBXN8, OTUB1, DUSP23, APOE, SRC, HRAS, CD97, ERICH5, FAM8A1, SPATA19, RAP2A, TPTE, STOM, COX15, SOAT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAH11_VDAC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAH11_VDAC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DNAH11 | C0010068 | Coronary heart disease | 1 | CTD_human |
Hgene | DNAH11 | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | DNAH11 | C0242339 | Dyslipidemias | 1 | CTD_human |
Hgene | DNAH11 | C2678473 | CILIARY DYSKINESIA, PRIMARY, 7 (disorder) | 1 | CTD_human;UNIPROT |