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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10174

FusionGeneSummary for DNAH11_MICAL2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH11_MICAL2
Fusion gene ID: 10174
HgeneTgene
Gene symbol

DNAH11

MICAL2

Gene ID

8701

9645

Gene namedynein axonemal heavy chain 11microtubule associated monooxygenase, calponin and LIM domain containing 2
SynonymsCILD7|DNAHBL|DNAHC11|DNHBL|DPL11MICAL-2|MICAL2PV1|MICAL2PV2
Cytomap

7p15.3

11p15.3

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11[F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxide
Modification date2018052320180519
UniProtAcc

Q96DT5

O94851

Ensembl transtripts involved in fusion geneENST00000409508, ENST00000328843, 
ENST00000465593, 
ENST00000537344, 
ENST00000256194, ENST00000527546, 
ENST00000342902, ENST00000379612, 
ENST00000527195, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 5 X 3=75
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAH11 [Title/Abstract] AND MICAL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMICAL2

GO:0007010

cytoskeleton organization

24440334

TgeneMICAL2

GO:0030042

actin filament depolymerization

24440334

TgeneMICAL2

GO:0055114

oxidation-reduction process

24440334


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW664742DNAH11chr7

21940717

+MICAL2chr11

12238868

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409508ENST00000537344DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000409508ENST00000256194DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000409508ENST00000527546DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000409508ENST00000342902DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000409508ENST00000379612DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000409508ENST00000527195DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000328843ENST00000537344DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000328843ENST00000256194DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000328843ENST00000527546DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000328843ENST00000342902DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000328843ENST00000379612DNAH11chr7

21940717

+MICAL2chr11

12238868

-
5CDS-intronENST00000328843ENST00000527195DNAH11chr7

21940717

+MICAL2chr11

12238868

-
intron-intronENST00000465593ENST00000537344DNAH11chr7

21940717

+MICAL2chr11

12238868

-
intron-intronENST00000465593ENST00000256194DNAH11chr7

21940717

+MICAL2chr11

12238868

-
intron-intronENST00000465593ENST00000527546DNAH11chr7

21940717

+MICAL2chr11

12238868

-
intron-intronENST00000465593ENST00000342902DNAH11chr7

21940717

+MICAL2chr11

12238868

-
intron-intronENST00000465593ENST00000379612DNAH11chr7

21940717

+MICAL2chr11

12238868

-
intron-intronENST00000465593ENST00000527195DNAH11chr7

21940717

+MICAL2chr11

12238868

-

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FusionProtFeatures for DNAH11_MICAL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH11

Q96DT5

MICAL2

O94851

Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. Nuclear monooxygenase that promotes depolymerization ofF-actin by mediating oxidation of specific methionine residues onactin to form methionine-sulfoxide, resulting in actin filamentdisassembly and preventing repolymerization. In the absence ofactin, it also functions as a NADPH oxidase producing H(2)O(2) (Bysimilarity). Acts as a key regulator of the SRF signaling pathwayelicited by nerve growth factor and serum: mediates oxidation andsubsequent depolymerization of nuclear actin, leading to increaseMKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-Athrough RhoA. {ECO:0000250|UniProtKB:Q8BML1,ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAH11_MICAL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAH11_MICAL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAH11_MICAL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAH11_MICAL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNAH11C0010068Coronary heart disease1CTD_human
HgeneDNAH11C0043094Weight Gain1CTD_human
HgeneDNAH11C0242339Dyslipidemias1CTD_human
HgeneDNAH11C2678473CILIARY DYSKINESIA, PRIMARY, 7 (disorder)1CTD_human;UNIPROT