![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 10174 |
FusionGeneSummary for DNAH11_MICAL2 |
![]() |
Fusion gene information | Fusion gene name: DNAH11_MICAL2 | Fusion gene ID: 10174 | Hgene | Tgene | Gene symbol | DNAH11 | MICAL2 | Gene ID | 8701 | 9645 |
Gene name | dynein axonemal heavy chain 11 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | |
Synonyms | CILD7|DNAHBL|DNAHC11|DNHBL|DPL11 | MICAL-2|MICAL2PV1|MICAL2PV2 | |
Cytomap | 7p15.3 | 11p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | dynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11 | [F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxide | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q96DT5 | O94851 | |
Ensembl transtripts involved in fusion gene | ENST00000409508, ENST00000328843, ENST00000465593, | ENST00000537344, ENST00000256194, ENST00000527546, ENST00000342902, ENST00000379612, ENST00000527195, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 3=75 |
# samples | 4 | 5 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAH11 [Title/Abstract] AND MICAL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MICAL2 | GO:0007010 | cytoskeleton organization | 24440334 |
Tgene | MICAL2 | GO:0030042 | actin filament depolymerization | 24440334 |
Tgene | MICAL2 | GO:0055114 | oxidation-reduction process | 24440334 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW664742 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000409508 | ENST00000537344 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000409508 | ENST00000256194 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000409508 | ENST00000527546 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000409508 | ENST00000342902 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000409508 | ENST00000379612 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000409508 | ENST00000527195 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000328843 | ENST00000537344 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000328843 | ENST00000256194 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000328843 | ENST00000527546 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000328843 | ENST00000342902 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000328843 | ENST00000379612 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
5CDS-intron | ENST00000328843 | ENST00000527195 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
intron-intron | ENST00000465593 | ENST00000537344 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
intron-intron | ENST00000465593 | ENST00000256194 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
intron-intron | ENST00000465593 | ENST00000527546 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
intron-intron | ENST00000465593 | ENST00000342902 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
intron-intron | ENST00000465593 | ENST00000379612 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
intron-intron | ENST00000465593 | ENST00000527195 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
Top |
FusionProtFeatures for DNAH11_MICAL2 |
![]() |
Hgene | Tgene |
DNAH11 | MICAL2 |
Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. | Nuclear monooxygenase that promotes depolymerization ofF-actin by mediating oxidation of specific methionine residues onactin to form methionine-sulfoxide, resulting in actin filamentdisassembly and preventing repolymerization. In the absence ofactin, it also functions as a NADPH oxidase producing H(2)O(2) (Bysimilarity). Acts as a key regulator of the SRF signaling pathwayelicited by nerve growth factor and serum: mediates oxidation andsubsequent depolymerization of nuclear actin, leading to increaseMKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-Athrough RhoA. {ECO:0000250|UniProtKB:Q8BML1,ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for DNAH11_MICAL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for DNAH11_MICAL2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DNAH11_MICAL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DNAH11_MICAL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DNAH11 | C0010068 | Coronary heart disease | 1 | CTD_human |
Hgene | DNAH11 | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | DNAH11 | C0242339 | Dyslipidemias | 1 | CTD_human |
Hgene | DNAH11 | C2678473 | CILIARY DYSKINESIA, PRIMARY, 7 (disorder) | 1 | CTD_human;UNIPROT |