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Fusion gene ID: 10174 |
FusionGeneSummary for DNAH11_MICAL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAH11_MICAL2 | Fusion gene ID: 10174 | Hgene | Tgene | Gene symbol | DNAH11 | MICAL2 | Gene ID | 8701 | 9645 |
| Gene name | dynein axonemal heavy chain 11 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | |
| Synonyms | CILD7|DNAHBL|DNAHC11|DNHBL|DPL11 | MICAL-2|MICAL2PV1|MICAL2PV2 | |
| Cytomap | 7p15.3 | 11p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11 | [F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxide | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96DT5 | O94851 | |
| Ensembl transtripts involved in fusion gene | ENST00000409508, ENST00000328843, ENST00000465593, | ENST00000537344, ENST00000256194, ENST00000527546, ENST00000342902, ENST00000379612, ENST00000527195, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 3=75 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DNAH11 [Title/Abstract] AND MICAL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MICAL2 | GO:0007010 | cytoskeleton organization | 24440334 |
| Tgene | MICAL2 | GO:0030042 | actin filament depolymerization | 24440334 |
| Tgene | MICAL2 | GO:0055114 | oxidation-reduction process | 24440334 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW664742 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000409508 | ENST00000537344 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000409508 | ENST00000256194 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000409508 | ENST00000527546 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000409508 | ENST00000342902 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000409508 | ENST00000379612 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000409508 | ENST00000527195 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000328843 | ENST00000537344 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000328843 | ENST00000256194 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000328843 | ENST00000527546 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000328843 | ENST00000342902 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000328843 | ENST00000379612 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| 5CDS-intron | ENST00000328843 | ENST00000527195 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| intron-intron | ENST00000465593 | ENST00000537344 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| intron-intron | ENST00000465593 | ENST00000256194 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| intron-intron | ENST00000465593 | ENST00000527546 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| intron-intron | ENST00000465593 | ENST00000342902 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| intron-intron | ENST00000465593 | ENST00000379612 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
| intron-intron | ENST00000465593 | ENST00000527195 | DNAH11 | chr7 | 21940717 | + | MICAL2 | chr11 | 12238868 | - |
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FusionProtFeatures for DNAH11_MICAL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAH11 | MICAL2 |
| Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. | Nuclear monooxygenase that promotes depolymerization ofF-actin by mediating oxidation of specific methionine residues onactin to form methionine-sulfoxide, resulting in actin filamentdisassembly and preventing repolymerization. In the absence ofactin, it also functions as a NADPH oxidase producing H(2)O(2) (Bysimilarity). Acts as a key regulator of the SRF signaling pathwayelicited by nerve growth factor and serum: mediates oxidation andsubsequent depolymerization of nuclear actin, leading to increaseMKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-Athrough RhoA. {ECO:0000250|UniProtKB:Q8BML1,ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAH11_MICAL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAH11_MICAL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAH11_MICAL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAH11_MICAL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DNAH11 | C0010068 | Coronary heart disease | 1 | CTD_human |
| Hgene | DNAH11 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | DNAH11 | C0242339 | Dyslipidemias | 1 | CTD_human |
| Hgene | DNAH11 | C2678473 | CILIARY DYSKINESIA, PRIMARY, 7 (disorder) | 1 | CTD_human;UNIPROT |
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