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Fusion gene ID: 10172 |
FusionGeneSummary for DNAH11_CLSTN1 |
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Fusion gene information | Fusion gene name: DNAH11_CLSTN1 | Fusion gene ID: 10172 | Hgene | Tgene | Gene symbol | DNAH11 | CLSTN1 | Gene ID | 8701 | 22883 |
Gene name | dynein axonemal heavy chain 11 | calsyntenin 1 | |
Synonyms | CILD7|DNAHBL|DNAHC11|DNHBL|DPL11 | ALC-ALPHA|CDHR12|CST-1|CSTN1|PIK3CD|XB31alpha|alcalpha1|alcalpha2 | |
Cytomap | 7p15.3 | 1p36.22 | |
Type of gene | protein-coding | protein-coding | |
Description | dynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11 | calsyntenin-1alcadein-alphaalzheimer-related cadherin-like proteincadherin-related family member 12non-classical cadherin XB31alpha | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96DT5 | O94985 | |
Ensembl transtripts involved in fusion gene | ENST00000409508, ENST00000328843, ENST00000465593, | ENST00000377298, ENST00000361311, ENST00000377288, ENST00000477264, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 3=75 |
# samples | 4 | 7 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAH11 [Title/Abstract] AND CLSTN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG323744 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000409508 | ENST00000377298 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-3CDS | ENST00000409508 | ENST00000361311 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-3CDS | ENST00000409508 | ENST00000377288 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-intron | ENST00000409508 | ENST00000477264 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-3CDS | ENST00000328843 | ENST00000377298 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-3CDS | ENST00000328843 | ENST00000361311 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-3CDS | ENST00000328843 | ENST00000377288 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-intron | ENST00000328843 | ENST00000477264 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-3CDS | ENST00000465593 | ENST00000377298 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-3CDS | ENST00000465593 | ENST00000361311 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-3CDS | ENST00000465593 | ENST00000377288 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
intron-intron | ENST00000465593 | ENST00000477264 | DNAH11 | chr7 | 21759373 | + | CLSTN1 | chr1 | 9809706 | - |
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FusionProtFeatures for DNAH11_CLSTN1 |
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Hgene | Tgene |
DNAH11 | CLSTN1 |
Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. | Induces KLC1 association with vesicles and functions asa cargo in axonal anterograde transport. Complex formation withAPBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to theretardation of intracellular APP maturation. In complex with APBA2and C99, a C-terminal APP fragment, abolishes C99 interaction withPSEN1 and thus APP C99 cleavage by gamma-secretase, most probablythrough stabilization of the direct interaction between APBA2 andAPP. The intracellular fragment AlcICD suppresses APBB1-dependenttransactivation stimulated by APP C-terminal intracellularfragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:12972431}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAH11_CLSTN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAH11_CLSTN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAH11_CLSTN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAH11_CLSTN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DNAH11 | C0010068 | Coronary heart disease | 1 | CTD_human |
Hgene | DNAH11 | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | DNAH11 | C0242339 | Dyslipidemias | 1 | CTD_human |
Hgene | DNAH11 | C2678473 | CILIARY DYSKINESIA, PRIMARY, 7 (disorder) | 1 | CTD_human;UNIPROT |