FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10172

FusionGeneSummary for DNAH11_CLSTN1

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH11_CLSTN1
Fusion gene ID: 10172
HgeneTgene
Gene symbol

DNAH11

CLSTN1

Gene ID

8701

22883

Gene namedynein axonemal heavy chain 11calsyntenin 1
SynonymsCILD7|DNAHBL|DNAHC11|DNHBL|DPL11ALC-ALPHA|CDHR12|CST-1|CSTN1|PIK3CD|XB31alpha|alcalpha1|alcalpha2
Cytomap

7p15.3

1p36.22

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11calsyntenin-1alcadein-alphaalzheimer-related cadherin-like proteincadherin-related family member 12non-classical cadherin XB31alpha
Modification date2018052320180523
UniProtAcc

Q96DT5

O94985

Ensembl transtripts involved in fusion geneENST00000409508, ENST00000328843, 
ENST00000465593, 
ENST00000377298, 
ENST00000361311, ENST00000377288, 
ENST00000477264, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 5 X 3=75
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAH11 [Title/Abstract] AND CLSTN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG323744DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000409508ENST00000377298DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-3CDSENST00000409508ENST00000361311DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-3CDSENST00000409508ENST00000377288DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-intronENST00000409508ENST00000477264DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-3CDSENST00000328843ENST00000377298DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-3CDSENST00000328843ENST00000361311DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-3CDSENST00000328843ENST00000377288DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-intronENST00000328843ENST00000477264DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-3CDSENST00000465593ENST00000377298DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-3CDSENST00000465593ENST00000361311DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-3CDSENST00000465593ENST00000377288DNAH11chr7

21759373

+CLSTN1chr1

9809706

-
intron-intronENST00000465593ENST00000477264DNAH11chr7

21759373

+CLSTN1chr1

9809706

-

Top

FusionProtFeatures for DNAH11_CLSTN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH11

Q96DT5

CLSTN1

O94985

Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. Induces KLC1 association with vesicles and functions asa cargo in axonal anterograde transport. Complex formation withAPBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to theretardation of intracellular APP maturation. In complex with APBA2and C99, a C-terminal APP fragment, abolishes C99 interaction withPSEN1 and thus APP C99 cleavage by gamma-secretase, most probablythrough stabilization of the direct interaction between APBA2 andAPP. The intracellular fragment AlcICD suppresses APBB1-dependenttransactivation stimulated by APP C-terminal intracellularfragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:12972431}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DNAH11_CLSTN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DNAH11_CLSTN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DNAH11_CLSTN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DNAH11_CLSTN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNAH11C0010068Coronary heart disease1CTD_human
HgeneDNAH11C0043094Weight Gain1CTD_human
HgeneDNAH11C0242339Dyslipidemias1CTD_human
HgeneDNAH11C2678473CILIARY DYSKINESIA, PRIMARY, 7 (disorder)1CTD_human;UNIPROT