![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 10164 |
FusionGeneSummary for DMXL1_NANS |
![]() |
Fusion gene information | Fusion gene name: DMXL1_NANS | Fusion gene ID: 10164 | Hgene | Tgene | Gene symbol | DMXL1 | NANS | Gene ID | 1657 | 54187 |
Gene name | Dmx like 1 | N-acetylneuraminate synthase | |
Synonyms | - | HEL-S-100|SAS|SEMDCG|SEMDG | |
Cytomap | 5q23.1 | 9q22.33 | |
Type of gene | protein-coding | protein-coding | |
Description | dmX-like protein 1 | sialic acid synthaseN-acetylneuraminate-9-phosphate synthaseN-acetylneuraminic acid phosphate synthaseN-acetylneuraminic acid synthaseepididymis secretory protein Li 100sialic acid phosphate synthase | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9Y485 | Q9NR45 | |
Ensembl transtripts involved in fusion gene | ENST00000311085, ENST00000539542, ENST00000505312, | ENST00000210444, ENST00000461452, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DMXL1 [Title/Abstract] AND NANS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A1KZ-01A | DMXL1 | chr5 | 118407351 | + | NANS | chr9 | 100843098 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000311085 | ENST00000210444 | DMXL1 | chr5 | 118407351 | + | NANS | chr9 | 100843098 | + |
5CDS-3UTR | ENST00000311085 | ENST00000461452 | DMXL1 | chr5 | 118407351 | + | NANS | chr9 | 100843098 | + |
In-frame | ENST00000539542 | ENST00000210444 | DMXL1 | chr5 | 118407351 | + | NANS | chr9 | 100843098 | + |
5CDS-3UTR | ENST00000539542 | ENST00000461452 | DMXL1 | chr5 | 118407351 | + | NANS | chr9 | 100843098 | + |
intron-3CDS | ENST00000505312 | ENST00000210444 | DMXL1 | chr5 | 118407351 | + | NANS | chr9 | 100843098 | + |
intron-3UTR | ENST00000505312 | ENST00000461452 | DMXL1 | chr5 | 118407351 | + | NANS | chr9 | 100843098 | + |
Top |
FusionProtFeatures for DMXL1_NANS |
![]() |
Hgene | Tgene |
DMXL1 | NANS |
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate assubstrates to generate phosphorylated forms of Neu5Ac and KDN,respectively. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >NANS | chr5:118407351 | chr9:100843098 | ENST00000210444 | + | 3 | 6 | 294_353 | 201 | 360 | Domain | AFP-like |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 2459_2468 | 29 | 3028 | Compositional bias | Note=Poly-Asp |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 108_145 | 29 | 3028 | Repeat | Note=WD 1 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 1134_1175 | 29 | 3028 | Repeat | Note=WD 9 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 1211_1251 | 29 | 3028 | Repeat | Note=WD 10 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 166_206 | 29 | 3028 | Repeat | Note=WD 2 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 229_277 | 29 | 3028 | Repeat | Note=WD 3 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 2742_2783 | 29 | 3028 | Repeat | Note=WD 11 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 2785_2824 | 29 | 3028 | Repeat | Note=WD 12 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 2836_2878 | 29 | 3028 | Repeat | Note=WD 12 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 2884_2923 | 29 | 3028 | Repeat | Note=WD 14 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 2926_2965 | 29 | 3028 | Repeat | Note=WD 15 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 2978_3016 | 29 | 3028 | Repeat | Note=WD 16 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 476_516 | 29 | 3028 | Repeat | Note=WD 4 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 580_621 | 29 | 3028 | Repeat | Note=WD 5 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 628_665 | 29 | 3028 | Repeat | Note=WD 6 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 848_895 | 29 | 3028 | Repeat | Note=WD 7 |
Hgene | >DMXL1 | chr5:118407351 | chr9:100843098 | ENST00000311085 | + | 1 | 43 | 968_1010 | 29 | 3028 | Repeat | Note=WD 8 |
Top |
FusionGeneSequence for DMXL1_NANS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_DMXL1_ENST00000311085_chr5_118407351_+_NANS_ENST00000210444_chr9_100843098_+_188aa MNLHQVLTGAVNPGDHCFSVGSIGDQRFTEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAEL VRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPEGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEELVDN >In-frame_DMXL1_ENST00000539542_chr5_118407351_+_NANS_ENST00000210444_chr9_100843098_+_188aa MNLHQVLTGAVNPGDHCFSVGSIGDQRFTEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAEL VRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPEGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEELVDN |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_DMXL1_ENST00000311085_chr5_118407351_+_NANS_ENST00000210444_chr9_100843098_+_564nt ATGAACCTGCACCAGGTGCTGACCGGGGCTGTGAACCCTGGCGACCACTGCTTCTCCGTGGGCAGCATTGGCGACCAGCGCTTCACGGAA TATCAGAAGCTCTTTCCTGACATTCCCATAGGGTATTCTGGGCATGAAACAGGCATAGCGATATCTGTGGCCGCAGTGGCTCTGGGGGCC AAGGTGTTGGAACGTCACATAACTTTGGACAAGACCTGGAAGGGGAGTGACCACTCGGCCTCGCTGGAGCCTGGAGAACTGGCCGAGCTG GTGCGGTCAGTGCGTCTTGTGGAGCGTGCCCTGGGCTCCCCAACCAAGCAGCTGCTGCCCTGTGAGATGGCCTGCAATGAGAAGCTGGGC AAGTCTGTGGTGGCCAAAGTGAAAATTCCGGAAGGCACCATTCTAACAATGGACATGCTCACCGTGAAGGTGGGTGAGCCCAAAGGCTAT CCTCCTGAAGACATCTTTAATCTAGTGGGCAAGAAGGTCCTGGTCACTGTTGAAGAGGATGACACCATCATGGAAGAATTGGTAGATAAT >In-frame_DMXL1_ENST00000539542_chr5_118407351_+_NANS_ENST00000210444_chr9_100843098_+_564nt ATGAACCTGCACCAGGTGCTGACCGGGGCTGTGAACCCTGGCGACCACTGCTTCTCCGTGGGCAGCATTGGCGACCAGCGCTTCACGGAA TATCAGAAGCTCTTTCCTGACATTCCCATAGGGTATTCTGGGCATGAAACAGGCATAGCGATATCTGTGGCCGCAGTGGCTCTGGGGGCC AAGGTGTTGGAACGTCACATAACTTTGGACAAGACCTGGAAGGGGAGTGACCACTCGGCCTCGCTGGAGCCTGGAGAACTGGCCGAGCTG GTGCGGTCAGTGCGTCTTGTGGAGCGTGCCCTGGGCTCCCCAACCAAGCAGCTGCTGCCCTGTGAGATGGCCTGCAATGAGAAGCTGGGC AAGTCTGTGGTGGCCAAAGTGAAAATTCCGGAAGGCACCATTCTAACAATGGACATGCTCACCGTGAAGGTGGGTGAGCCCAAAGGCTAT CCTCCTGAAGACATCTTTAATCTAGTGGGCAAGAAGGTCCTGGTCACTGTTGAAGAGGATGACACCATCATGGAAGAATTGGTAGATAAT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_DMXL1_ENST00000311085_chr5_118407351_+_NANS_ENST00000210444_chr9_100843098_+_664nt GAGGGAAGGAGGGAGGGAAGCAGCCGCTGACCCGTGGCATGAGCTGGATGCGGTGTCCGTTGCAGGACTAGGGCGCCGACATGAACCTGC ACCAGGTGCTGACCGGGGCTGTGAACCCTGGCGACCACTGCTTCTCCGTGGGCAGCATTGGCGACCAGCGCTTCACGGAATATCAGAAGC TCTTTCCTGACATTCCCATAGGGTATTCTGGGCATGAAACAGGCATAGCGATATCTGTGGCCGCAGTGGCTCTGGGGGCCAAGGTGTTGG AACGTCACATAACTTTGGACAAGACCTGGAAGGGGAGTGACCACTCGGCCTCGCTGGAGCCTGGAGAACTGGCCGAGCTGGTGCGGTCAG TGCGTCTTGTGGAGCGTGCCCTGGGCTCCCCAACCAAGCAGCTGCTGCCCTGTGAGATGGCCTGCAATGAGAAGCTGGGCAAGTCTGTGG TGGCCAAAGTGAAAATTCCGGAAGGCACCATTCTAACAATGGACATGCTCACCGTGAAGGTGGGTGAGCCCAAAGGCTATCCTCCTGAAG ACATCTTTAATCTAGTGGGCAAGAAGGTCCTGGTCACTGTTGAAGAGGATGACACCATCATGGAAGAATTGGTAGATAATCATGGCAAAA >In-frame_DMXL1_ENST00000539542_chr5_118407351_+_NANS_ENST00000210444_chr9_100843098_+_610nt GTCCGTTGCAGGACTAGGGCGCCGACATGAACCTGCACCAGGTGCTGACCGGGGCTGTGAACCCTGGCGACCACTGCTTCTCCGTGGGCA GCATTGGCGACCAGCGCTTCACGGAATATCAGAAGCTCTTTCCTGACATTCCCATAGGGTATTCTGGGCATGAAACAGGCATAGCGATAT CTGTGGCCGCAGTGGCTCTGGGGGCCAAGGTGTTGGAACGTCACATAACTTTGGACAAGACCTGGAAGGGGAGTGACCACTCGGCCTCGC TGGAGCCTGGAGAACTGGCCGAGCTGGTGCGGTCAGTGCGTCTTGTGGAGCGTGCCCTGGGCTCCCCAACCAAGCAGCTGCTGCCCTGTG AGATGGCCTGCAATGAGAAGCTGGGCAAGTCTGTGGTGGCCAAAGTGAAAATTCCGGAAGGCACCATTCTAACAATGGACATGCTCACCG TGAAGGTGGGTGAGCCCAAAGGCTATCCTCCTGAAGACATCTTTAATCTAGTGGGCAAGAAGGTCCTGGTCACTGTTGAAGAGGATGACA |
Top |
FusionGenePPI for DMXL1_NANS |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DMXL1 | CALM1, ROGDI, ATP6V1C2, ATP6V1B1, RAP1B, RNASEH2A, ATOH1, TRIM25 | NANS | DDA1, PCMT1, CRK, RAD23B, HSP90AA1, HSP90AB1, BAG3, EIF4E, GBP2, ASS1, ATG3, CKB, CNDP2, DAK, MVD, NPEPPS, PDIA3, POLE3, RPLP2, SLC9A3R1, SMEK2, SHMT2, NXF1, AKR1A1, FAHD1, GOT1, MPI, CARKD, DAZAP1, FH, GLOD4, PIR, PKM, TKT, PRDX1, PRDX2, NTRK1, PA2G4, ANXA5, GPI, UBE2N, PPA1, HPRT1, PLS3, TRAP1, SND1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DMXL1_NANS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DMXL1_NANS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DMXL1 | C0017638 | Glioma | 1 | CTD_human |
Tgene | NANS | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
Tgene | NANS | C0008073 | Developmental Disabilities | 1 | CTD_human |
Tgene | NANS | C1864872 | Spondyloepimetaphyseal dysplasia, Genevieve type | 1 | ORPHANET;UNIPROT |