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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10162

FusionGeneSummary for DMWD_KDM4C

check button Fusion gene summary
Fusion gene informationFusion gene name: DMWD_KDM4C
Fusion gene ID: 10162
HgeneTgene
Gene symbol

DMWD

KDM4C

Gene ID

1762

23081

Gene nameDM1 locus, WD repeat containinglysine demethylase 4C
SynonymsD19S593E|DMR-N9|DMRN9|gene59GASC1|JHDM3C|JMJD2C|TDRD14C
Cytomap

19q13.32

9p24.1

Type of geneprotein-codingprotein-coding
Descriptiondystrophia myotonica WD repeat-containing proteindystrophia myotonica, WD repeat containingdystrophia myotonica-containing WD repeat motif proteinprotein 59lysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
Modification date2018051920180523
UniProtAcc

Q09019

Q9H3R0

Ensembl transtripts involved in fusion geneENST00000377735, ENST00000270223, 
ENST00000601370, 		ENST00000535193, 
ENST00000543771, ENST00000381306, 
ENST00000381309, ENST00000442236, 
ENST00000489243, ENST00000536108, 
ENST00000428870, ENST00000401787, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 4 X 4=80
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DMWD [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

TgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

TgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-V1-A9O5-06ADMWDchr19

46294163

-KDM4Cchr9

7128066

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377735ENST00000535193DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000377735ENST00000543771DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000377735ENST00000381306DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000377735ENST00000381309DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000377735ENST00000442236DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000377735ENST00000489243DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-3UTRENST00000377735ENST00000536108DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-3UTRENST00000377735ENST00000428870DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000377735ENST00000401787DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000270223ENST00000535193DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000270223ENST00000543771DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000270223ENST00000381306DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000270223ENST00000381309DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000270223ENST00000442236DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000270223ENST00000489243DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-3UTRENST00000270223ENST00000536108DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-3UTRENST00000270223ENST00000428870DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5CDS-intronENST00000270223ENST00000401787DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-intronENST00000601370ENST00000535193DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-intronENST00000601370ENST00000543771DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-intronENST00000601370ENST00000381306DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-intronENST00000601370ENST00000381309DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-intronENST00000601370ENST00000442236DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-intronENST00000601370ENST00000489243DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-3UTRENST00000601370ENST00000536108DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-3UTRENST00000601370ENST00000428870DMWDchr19

46294163

-KDM4Cchr9

7128066

+
5UTR-intronENST00000601370ENST00000401787DMWDchr19

46294163

-KDM4Cchr9

7128066

+

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FusionProtFeatures for DMWD_KDM4C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DMWD

Q09019

KDM4C

Q9H3R0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DMWD_KDM4C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DMWD_KDM4C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DMWDALB, CAPZB, CTSB, USP12, USP19, USP46, WDR48, F7, FLNA, GALK1, HBB, HSPB1, IDH3A, NDUFA5, NDUFS2, OAT, PFKL, PFKP, S100A8, SDF2, SRM, TSNAX, VARS, YWHAH, SUCLG2, P4HA2, NPEPPS, NUP155, CDC37, PHLPP1, SCRIB, FTSJ1, TRMT2A, DCXR, SARS2, CUL3, RFPL2, GPR3, FEM1B, GAK, DCAF15, ARHGAP25, XPO1, RSRP1, PHLPP2, WDR6, TKT, ALOX5, FERD3L, WDFY3, ZNF581, RAB2B, APBA2, ALDH3B1, BCAT1, C1QB, GNAZ, TRIM25KDM4CKDM4A, KDM4C, HIST1H3A, H3F3A, PPARG, HDAC1, HDAC3, HIST2H3C, SHMT2, MOV10, NXF1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DMWD_KDM4C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DMWD_KDM4C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKDM4CC0025149Medulloblastoma1CTD_human
TgeneKDM4CC0236663Alcohol withdrawal syndrome1PSYGENET