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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10089

FusionGeneSummary for DLG1_ZIC1

check button Fusion gene summary
Fusion gene informationFusion gene name: DLG1_ZIC1
Fusion gene ID: 10089
HgeneTgene
Gene symbol

DLG1

ZIC1

Gene ID

1739

7545

Gene namediscs large MAGUK scaffold protein 1Zic family member 1
SynonymsDLGH1|SAP-97|SAP97|dJ1061C18.1.1|hdlgCRS6|ZIC|ZNF201
Cytomap

3q29

3q24

Type of geneprotein-codingprotein-coding
Descriptiondisks large homolog 1discs large homolog 1, scribble cell polarity complex componentdiscs, large homolog 1 transcript variant 6-v1discs, large homolog 1 transcript variant 6-v2presynaptic protein SAP97synapse-associated protein 97zinc finger protein ZIC 1Zic family member 1 (odd-paired homolog, Drosophila)Zinc finger protein of the cerebellum 1zinc finger protein 201
Modification date2018052320180523
UniProtAcc

Q12959

Q15915

Ensembl transtripts involved in fusion geneENST00000357674, ENST00000314062, 
ENST00000346964, ENST00000419354, 
ENST00000452595, ENST00000422288, 
ENST00000448528, ENST00000443183, 
ENST00000450955, ENST00000392382, 
ENST00000485409, 
ENST00000474034, 
ENST00000282928, 
Fusion gene scores* DoF score20 X 10 X 13=26003 X 3 X 3=27
# samples 233
** MAII scorelog2(23/2600*10)=-3.49880585697144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DLG1 [Title/Abstract] AND ZIC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLG1

GO:0001935

endothelial cell proliferation

14699157

HgeneDLG1

GO:0007015

actin filament organization

14699157

HgeneDLG1

GO:0030866

cortical actin cytoskeleton organization

14699157

HgeneDLG1

GO:0042391

regulation of membrane potential

12970345

HgeneDLG1

GO:0043268

positive regulation of potassium ion transport

12970345

HgeneDLG1

GO:0070830

bicellular tight junction assembly

17332497

HgeneDLG1

GO:0098609

cell-cell adhesion

14699157

HgeneDLG1

GO:1903078

positive regulation of protein localization to plasma membrane

12970345

TgeneZIC1

GO:0007420

brain development

8542595


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-18-4086-01ADLG1chr3

197009550

-ZIC1chr3

147131141

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357674ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000357674ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000314062ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000314062ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000346964ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000346964ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000419354ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000419354ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
intron-intronENST00000452595ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
intron-intronENST00000452595ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000422288ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000422288ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000448528ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000448528ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
intron-intronENST00000443183ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
intron-intronENST00000443183ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000450955ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000450955ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000392382ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5CDS-intronENST00000392382ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+
5UTR-intronENST00000485409ENST00000474034DLG1chr3

197009550

-ZIC1chr3

147131141

+
5UTR-intronENST00000485409ENST00000282928DLG1chr3

197009550

-ZIC1chr3

147131141

+

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FusionProtFeatures for DLG1_ZIC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLG1

Q12959

ZIC1

Q15915

Acts as a transcriptional activator. Involved inneurogenesis. Plays important roles in the early stage oforganogenesis of the CNS, as well as during dorsal spinal corddevelopment and maturation of the cerebellum. Involved in thespatial distribution of mossy fiber (MF) neurons within thepontine gray nucleus (PGN). Plays a role in the regulation of MFaxon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flowmechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). {ECO:0000250|UniProtKB:P46684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DLG1_ZIC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DLG1_ZIC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DLG1KCNA4, ADAM17, KCNJ12, KCNJ4, GPR124, CASK, LIN7A, LIN7C, APBA1, KCNA5, GRIN2A, CAMK2A, GRIA1, BTRC, ACTN2, CACNG2, GRIN2B, EPB41, ATP2B4, CRIPT, DLGAP1, KCNJ6, GRIK2, TJAP1, LRRC1, ERBB4, ATP2B2, EZR, KIF13B, CTNNA1, KCNJ2, GUCY1A2, LCK, KCNA3, MARCH2, AMOT, UBE3A, NET1, KHDRBS1, KCNC1, MAP1A, BAI1, HUWE1, ADAM10, NTRK1, TMEM17, DLG3, KIF26B, MAPK12, PARK2, CDH1, TGFA, PTPRE, PTEN, MPP2, EFNB3, GJB7, PRDM1, GPRC5B, WWC1ZIC1GLI1, GLI2, GLI3, SDR9C7, PLBD1, GDPD3, CTSH, S100A7, SERPINB4, CAPNS2, CPA4, PLA2G4E, RNASE7, SERPINA3, SERPINB3, CTSV, SERPINB1, CASP14, ALOX12B, TGM1, S100P, KLK7, GM2A, AZGP1, LCN2, ACPP, ECM1, HAL, IVL, GSDMA, ARG1, NCCRP1, ASAH1, IMPA2, S100A16, APOD, KPRP, SERPINB13, S100A14, S100A9, CSTA, CAPN1, ALOXE3, GAPDH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DLG1_ZIC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DLG1_ZIC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLG1C0036341Schizophrenia3CTD_human
HgeneDLG1C0008925Cleft Palate1CTD_human
TgeneZIC1C4225269CRANIOSYNOSTOSIS 61UNIPROT