FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1008

FusionGeneSummary for AFF1_TRIM33

check button Fusion gene summary
Fusion gene informationFusion gene name: AFF1_TRIM33
Fusion gene ID: 1008
HgeneTgene
Gene symbol

AFF1

TRIM33

Gene ID

4299

51592

Gene nameAF4/FMR2 family member 1tripartite motif containing 33
SynonymsAF4|MLLT2|PBM1ECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMA
Cytomap

4q21.3-q22.1

1p13.2

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4E3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gamma
Modification date2018052320180520
UniProtAcc

P51825

Q9UPN9

Ensembl transtripts involved in fusion geneENST00000395146, ENST00000307808, 
ENST00000544085, ENST00000511996, 
ENST00000358465, ENST00000369543, 
ENST00000450349, ENST00000476908, 
Fusion gene scores* DoF score16 X 29 X 8=37122 X 2 X 1=4
# samples 402
** MAII scorelog2(40/3712*10)=-3.21412480535285
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: AFF1 [Title/Abstract] AND TRIM33 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM33

GO:0016567

protein ubiquitination

19135894

TgeneTRIM33

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

19135894

TgeneTRIM33

GO:0030514

negative regulation of BMP signaling pathway

19135894


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF368587AFF1chr4

88040933

+TRIM33chr1

115026919

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000395146ENST00000358465AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000395146ENST00000369543AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000395146ENST00000450349AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000395146ENST00000476908AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000307808ENST00000358465AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000307808ENST00000369543AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000307808ENST00000450349AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000307808ENST00000476908AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000544085ENST00000358465AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000544085ENST00000369543AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000544085ENST00000450349AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000544085ENST00000476908AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000511996ENST00000358465AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000511996ENST00000369543AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000511996ENST00000450349AFF1chr4

88040933

+TRIM33chr1

115026919

+
intron-intronENST00000511996ENST00000476908AFF1chr4

88040933

+TRIM33chr1

115026919

+

Top

FusionProtFeatures for AFF1_TRIM33


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF1

P51825

TRIM33

Q9UPN9

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4ubiquitination, nuclear exclusion and degradation via theubiquitin proteasome pathway. According to PubMed:16751102, doesnot promote a decrease in the level of endogenous SMAD4. May actas a transcriptional repressor. Inhibits the transcriptionalresponse to TGF-beta/BMP signaling cascade. Plays a role in thecontrol of cell proliferation. Its association with SMAD2 andSMAD3 stimulates erythroid differentiation of hematopoieticstem/progenitor (By similarity). Monoubiquitinates SMAD4 and actsas an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade(Monoubiquitination of SMAD4 hampers its ability to form a stablecomplex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250,ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681,ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for AFF1_TRIM33


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for AFF1_TRIM33


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for AFF1_TRIM33


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for AFF1_TRIM33


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource