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Fusion gene ID: 10062 |
FusionGeneSummary for DLEU1_DPH6 |
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Fusion gene information | Fusion gene name: DLEU1_DPH6 | Fusion gene ID: 10062 | Hgene | Tgene | Gene symbol | DLEU1 | DPH6 | Gene ID | 10301 | 89978 |
Gene name | deleted in lymphocytic leukemia 1 | diphthamine biosynthesis 6 | |
Synonyms | BCMS|BCMS1|DLB1|DLEU2|LEU1|LEU2|LINC00021|NCRNA00021|XTP6 | ATPBD4 | |
Cytomap | 13q14.2-q14.3 | 15q14 | |
Type of gene | ncRNA | protein-coding | |
Description | B-cell neoplasia-associated gene with multiple splicingdeleted in lymphocytic leukemia 1 (non-protein coding)leukemia-associated protein 2long intergenic non-protein coding RNA 21 | diphthine--ammonia ligaseATP binding domain 4ATP-binding domain-containing protein 4DPH6 homologdiphthamide synthasediphthamide synthetaseprotein DPH6 homolog | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O43261 | Q7L8W6 | |
Ensembl transtripts involved in fusion gene | ENST00000490577, ENST00000378180, | ENST00000560386, ENST00000256538, ENST00000440392, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 4 X 3=60 |
# samples | 3 | 5 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DLEU1 [Title/Abstract] AND DPH6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A07W-01A | DLEU1 | chr13 | 50657330 | + | DPH6 | chr15 | 35703097 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000490577 | ENST00000560386 | DLEU1 | chr13 | 50657330 | + | DPH6 | chr15 | 35703097 | - |
intron-intron | ENST00000490577 | ENST00000256538 | DLEU1 | chr13 | 50657330 | + | DPH6 | chr15 | 35703097 | - |
intron-intron | ENST00000490577 | ENST00000440392 | DLEU1 | chr13 | 50657330 | + | DPH6 | chr15 | 35703097 | - |
intron-intron | ENST00000378180 | ENST00000560386 | DLEU1 | chr13 | 50657330 | + | DPH6 | chr15 | 35703097 | - |
intron-intron | ENST00000378180 | ENST00000256538 | DLEU1 | chr13 | 50657330 | + | DPH6 | chr15 | 35703097 | - |
intron-intron | ENST00000378180 | ENST00000440392 | DLEU1 | chr13 | 50657330 | + | DPH6 | chr15 | 35703097 | - |
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FusionProtFeatures for DLEU1_DPH6 |
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Hgene | Tgene |
DLEU1 | DPH6 |
May act as a tumor suppressor. | Amidase that catalyzes the last step of diphthamidebiosynthesis using ammonium and ATP. Diphthamide biosynthesisconsists in the conversion of an L-histidine residue in thetranslation elongation factor (EEF2) to diphthamide (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:23169644}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DLEU1_DPH6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DLEU1_DPH6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DLEU1 | ABCD4, ABCF3, GDF9, CCDC90B, PSMA1, SETDB1, SHMT1, TLE1, MED31, COPS6, KAT5, KIAA1377, UTP14A, TP53, TUBB4B, UBR1, EEF1A1, EEF1G, GOPC | DPH6 | ATP2B2, KIAA1919, SLC18A1, ADAMTS4, S100A8, GRPR, PTGIR, TMCO3, C5AR2, SMARCB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DLEU1_DPH6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DLEU1_DPH6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |