FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10054

FusionGeneSummary for DLC1_DLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: DLC1_DLC1
Fusion gene ID: 10054
HgeneTgene
Gene symbol

DLC1

DLC1

Gene ID

10395

10395

Gene nameDLC1 Rho GTPase activating proteinDLC1 Rho GTPase activating protein
SynonymsARHGAP7|HP|STARD12|p122-RhoGAPARHGAP7|HP|STARD12|p122-RhoGAP
Cytomap

8p22

8p22

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer variarho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia
Modification date2018051920180519
UniProtAcc

Q96QB1

Q96QB1

Ensembl transtripts involved in fusion geneENST00000276297, ENST00000358919, 
ENST00000512044, ENST00000316609, 
ENST00000511869, ENST00000510318, 
ENST00000520226, 
ENST00000276297, 
ENST00000358919, ENST00000512044, 
ENST00000316609, ENST00000511869, 
ENST00000510318, ENST00000520226, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 7 X 4=224
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLC1 [Title/Abstract] AND DLC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLC1

GO:0006915

apoptotic process

17292327

HgeneDLC1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

HgeneDLC1

GO:0008285

negative regulation of cell proliferation

12545165|17932950

HgeneDLC1

GO:0030336

negative regulation of cell migration

17932950|19158340

HgeneDLC1

GO:0035307

positive regulation of protein dephosphorylation

17292327

HgeneDLC1

GO:0051497

negative regulation of stress fiber assembly

17932950

HgeneDLC1

GO:0051895

negative regulation of focal adhesion assembly

19158340

HgeneDLC1

GO:1900119

positive regulation of execution phase of apoptosis

17888903

TgeneDLC1

GO:0006915

apoptotic process

17292327

TgeneDLC1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

TgeneDLC1

GO:0008285

negative regulation of cell proliferation

12545165|17932950

TgeneDLC1

GO:0030336

negative regulation of cell migration

17932950|19158340

TgeneDLC1

GO:0035307

positive regulation of protein dephosphorylation

17292327

TgeneDLC1

GO:0051497

negative regulation of stress fiber assembly

17932950

TgeneDLC1

GO:0051895

negative regulation of focal adhesion assembly

19158340

TgeneDLC1

GO:1900119

positive regulation of execution phase of apoptosis

17888903


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T78001DLC1chr8

13356639

+DLC1chr8

13356582

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000276297ENST00000276297DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000276297ENST00000358919DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000276297ENST00000512044DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000276297ENST00000316609DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000276297ENST00000511869DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000276297ENST00000510318DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000276297ENST00000520226DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-3CDSENST00000358919ENST00000276297DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000358919ENST00000358919DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000358919ENST00000512044DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000358919ENST00000316609DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000358919ENST00000511869DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000358919ENST00000510318DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000358919ENST00000520226DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-3CDSENST00000512044ENST00000276297DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000512044ENST00000358919DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000512044ENST00000512044DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000512044ENST00000316609DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000512044ENST00000511869DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000512044ENST00000510318DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000512044ENST00000520226DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-3CDSENST00000316609ENST00000276297DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000316609ENST00000358919DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000316609ENST00000512044DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000316609ENST00000316609DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000316609ENST00000511869DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000316609ENST00000510318DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000316609ENST00000520226DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-3CDSENST00000511869ENST00000276297DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000511869ENST00000358919DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000511869ENST00000512044DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000511869ENST00000316609DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000511869ENST00000511869DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000511869ENST00000510318DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000511869ENST00000520226DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-3CDSENST00000510318ENST00000276297DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000510318ENST00000358919DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000510318ENST00000512044DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000510318ENST00000316609DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000510318ENST00000511869DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000510318ENST00000510318DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000510318ENST00000520226DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-3CDSENST00000520226ENST00000276297DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000520226ENST00000358919DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000520226ENST00000512044DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000520226ENST00000316609DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000520226ENST00000511869DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000520226ENST00000510318DLC1chr8

13356639

+DLC1chr8

13356582

-
intron-intronENST00000520226ENST00000520226DLC1chr8

13356639

+DLC1chr8

13356582

-

Top

FusionProtFeatures for DLC1_DLC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLC1

Q96QB1

DLC1

Q96QB1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DLC1_DLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DLC1_DLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DLC1_DLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DLC1_DLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLC1C0038356Stomach Neoplasms1CTD_human;HPO
HgeneDLC1C0919267ovarian neoplasm1CTD_human
TgeneDLC1C0038356Stomach Neoplasms1CTD_human;HPO
TgeneDLC1C0919267ovarian neoplasm1CTD_human