FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10046

FusionGeneSummary for DIXDC1_MCF2

check button Fusion gene summary
Fusion gene informationFusion gene name: DIXDC1_MCF2
Fusion gene ID: 10046
HgeneTgene
Gene symbol

DIXDC1

MCF2

Gene ID

85458

4168

Gene nameDIX domain containing 1MCF.2 cell line derived transforming sequence
SynonymsCCD1ARHGEF21|DBL
Cytomap

11q23.1

Xq27.1

Type of geneprotein-codingprotein-coding
Descriptiondixincoiled-coil protein DIX1proto-oncogene DBLOncogene MCF2 (oncogene DBL)proto-oncogene MCF-2
Modification date2018052320180522
UniProtAcc

Q155Q3

P10911

Ensembl transtripts involved in fusion geneENST00000529225, ENST00000440460, 
ENST00000389821, ENST00000531396, 
ENST00000315253, 		ENST00000520602, 
ENST00000370576, ENST00000536274, 
ENST00000370578, ENST00000414978, 
ENST00000519895, ENST00000370573, 
ENST00000338585, ENST00000483690, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 1=9
# samples 63
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DIXDC1 [Title/Abstract] AND MCF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIXDC1

GO:0090263

positive regulation of canonical Wnt signaling pathway

21189423


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AB209679DIXDC1chr11

111817226

+MCF2chrX

138688401

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000529225ENST00000520602DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000529225ENST00000370576DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000529225ENST00000536274DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000529225ENST00000370578DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000529225ENST00000414978DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000529225ENST00000519895DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000529225ENST00000370573DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000529225ENST00000338585DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000529225ENST00000483690DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000520602DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000370576DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000536274DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000370578DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000414978DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000519895DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000370573DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000338585DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000440460ENST00000483690DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000520602DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000370576DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000536274DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000370578DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000414978DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000519895DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000370573DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000338585DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000389821ENST00000483690DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000520602DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000370576DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000536274DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000370578DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000414978DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000519895DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000370573DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000338585DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000531396ENST00000483690DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000520602DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000370576DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000536274DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000370578DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000414978DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000519895DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000370573DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000338585DIXDC1chr11

111817226

+MCF2chrX

138688401

-
intron-intronENST00000315253ENST00000483690DIXDC1chr11

111817226

+MCF2chrX

138688401

-

Top

FusionProtFeatures for DIXDC1_MCF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIXDC1

Q155Q3

MCF2

P10911


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DIXDC1_MCF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DIXDC1_MCF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DIXDC1_MCF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DIXDC1_MCF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDIXDC1C0003469Anxiety Disorders1CTD_human
HgeneDIXDC1C0004352Autistic Disorder1CTD_human
HgeneDIXDC1C0005586Bipolar Disorder1CTD_human
HgeneDIXDC1C0011581Depressive disorder1CTD_human
HgeneDIXDC1C0036341Schizophrenia1CTD_human