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Fusion gene ID: 9992 |
FusionGeneSummary for DIP2A_NRIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DIP2A_NRIP1 | Fusion gene ID: 9992 | Hgene | Tgene | Gene symbol | DIP2A | NRIP1 | Gene ID | 23181 | 8204 |
| Gene name | disco interacting protein 2 homolog A | nuclear receptor interacting protein 1 | |
| Synonyms | C21orf106|DIP2 | RIP140 | |
| Cytomap | 21q22.3 | 21q11.2-q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | disco-interacting protein 2 homolog ADIP2 disco-interacting protein 2 homolog ADIP2 homolog Adisco-interacting protein 2A | nuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14689 | P48552 | |
| Ensembl transtripts involved in fusion gene | ENST00000400274, ENST00000427143, ENST00000318711, ENST00000417564, ENST00000457905, ENST00000466639, ENST00000435722, ENST00000479654, | ENST00000318948, ENST00000400199, ENST00000400202, | |
| Fusion gene scores | * DoF score | 9 X 8 X 7=504 | 2 X 1 X 2=4 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/504*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: DIP2A [Title/Abstract] AND NRIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DIP2A | GO:0010629 | negative regulation of gene expression | 20860622 |
| Tgene | NRIP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10364267 |
| Tgene | NRIP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7641693|10364267 |
| Tgene | NRIP1 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-D6-A4Z9-01A | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000400274 | ENST00000318948 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000400274 | ENST00000400199 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000400274 | ENST00000400202 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000427143 | ENST00000318948 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000427143 | ENST00000400199 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000427143 | ENST00000400202 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000318711 | ENST00000318948 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000318711 | ENST00000400199 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000318711 | ENST00000400202 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000417564 | ENST00000318948 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000417564 | ENST00000400199 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000417564 | ENST00000400202 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000457905 | ENST00000318948 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000457905 | ENST00000400199 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000457905 | ENST00000400202 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000466639 | ENST00000318948 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000466639 | ENST00000400199 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000466639 | ENST00000400202 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000435722 | ENST00000318948 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000435722 | ENST00000400199 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| 5CDS-5UTR | ENST00000435722 | ENST00000400202 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| intron-5UTR | ENST00000479654 | ENST00000318948 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| intron-5UTR | ENST00000479654 | ENST00000400199 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
| intron-5UTR | ENST00000479654 | ENST00000400202 | DIP2A | chr21 | 47929289 | + | NRIP1 | chr21 | 16340847 | - |
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FusionProtFeatures for DIP2A_NRIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DIP2A | NRIP1 |