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Fusion gene ID: 9950 |
FusionGeneSummary for DHX8_ST6GALNAC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHX8_ST6GALNAC2 | Fusion gene ID: 9950 | Hgene | Tgene | Gene symbol | DHX8 | ST6GALNAC2 | Gene ID | 1659 | 10610 |
| Gene name | DEAH-box helicase 8 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | |
| Synonyms | DDX8|Dhr2|HRH1|PRP22|PRPF22 | SAITL1|SIAT7|SIAT7B|SIATL1|ST6GalNAII|STHM | |
| Cytomap | 17q21.31 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATP-dependent RNA helicase DHX8DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 8DEAH box protein 8RNA helicase HRH1 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferaseSIAT7-BST6 ( | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q14562 | Q9UJ37 | |
| Ensembl transtripts involved in fusion gene | ENST00000540306, ENST00000262415, | ENST00000225276, ENST00000586520, | |
| Fusion gene scores | * DoF score | 13 X 8 X 11=1144 | 5 X 3 X 3=45 |
| # samples | 13 | 5 | |
| ** MAII score | log2(13/1144*10)=-3.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DHX8 [Title/Abstract] AND ST6GALNAC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DHX8 | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
| Tgene | ST6GALNAC2 | GO:0006486 | protein glycosylation | 29251719 |
| Tgene | ST6GALNAC2 | GO:0006493 | protein O-linked glycosylation | 10742600 |
| Tgene | ST6GALNAC2 | GO:1990743 | protein sialylation | 10742600 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-VS-A8EJ-01A | DHX8 | chr17 | 41573636 | + | ST6GALNAC2 | chr17 | 74562353 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000540306 | ENST00000225276 | DHX8 | chr17 | 41573636 | + | ST6GALNAC2 | chr17 | 74562353 | - |
| 5CDS-intron | ENST00000540306 | ENST00000586520 | DHX8 | chr17 | 41573636 | + | ST6GALNAC2 | chr17 | 74562353 | - |
| Frame-shift | ENST00000262415 | ENST00000225276 | DHX8 | chr17 | 41573636 | + | ST6GALNAC2 | chr17 | 74562353 | - |
| 5CDS-intron | ENST00000262415 | ENST00000586520 | DHX8 | chr17 | 41573636 | + | ST6GALNAC2 | chr17 | 74562353 | - |
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FusionProtFeatures for DHX8_ST6GALNAC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHX8 | ST6GALNAC2 |