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Fusion gene ID: 9899 |
FusionGeneSummary for DHX15_CCDC149 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHX15_CCDC149 | Fusion gene ID: 9899 | Hgene | Tgene | Gene symbol | DHX15 | CCDC149 | Gene ID | 1665 | 91050 |
| Gene name | DEAH-box helicase 15 | coiled-coil domain containing 149 | |
| Synonyms | DBP1|DDX15|HRH2|PRP43|PRPF43|PrPp43p | - | |
| Cytomap | 4p15.2 | 4p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15ATP-dependent RNA helicase #46DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15DEAD/H box-15DEAH (Asp-Glu-Ala-His) box helicase 15DEAH (Asp-Glu-Ala-His) box polypeptide 15DEAH box protein 15RNA | coiled-coil domain-containing protein 149 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43143 | Q6ZUS6 | |
| Ensembl transtripts involved in fusion gene | ENST00000508032, ENST00000336812, | ENST00000504487, ENST00000428116, ENST00000389609, ENST00000502801, ENST00000508236, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 5 X 5 X 4=100 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DHX15 [Title/Abstract] AND CCDC149 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4449-01A | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000508032 | ENST00000504487 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| intron-intron | ENST00000508032 | ENST00000428116 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| intron-intron | ENST00000508032 | ENST00000389609 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| intron-intron | ENST00000508032 | ENST00000502801 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| intron-intron | ENST00000508032 | ENST00000508236 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| In-frame | ENST00000336812 | ENST00000504487 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| 5CDS-intron | ENST00000336812 | ENST00000428116 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| 5CDS-intron | ENST00000336812 | ENST00000389609 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| 5CDS-intron | ENST00000336812 | ENST00000502801 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| 5CDS-intron | ENST00000336812 | ENST00000508236 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
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FusionProtFeatures for DHX15_CCDC149 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHX15 | CCDC149 |