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Fusion gene ID: 9830 |
FusionGeneSummary for DGKD_SPP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DGKD_SPP2 | Fusion gene ID: 9830 | Hgene | Tgene | Gene symbol | DGKD | SPP2 | Gene ID | 8527 | 130367 |
| Gene name | diacylglycerol kinase delta | sphingosine-1-phosphate phosphatase 2 | |
| Synonyms | DGKdelta|dgkd-2 | SPP2|SPPase2 | |
| Cytomap | 2q37.1 | 2q36.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | diacylglycerol kinase deltaDAG kinase deltaDGK-deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta | sphingosine-1-phosphate phosphatase 2sphingosine 1-phosphate phosphohydrolase 2sphingosine-1-phosphatase 2sphingosine-1-phosphate phosphotase 2 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q16760 | Q13103 | |
| Ensembl transtripts involved in fusion gene | ENST00000264057, ENST00000409813, ENST00000489613, | ENST00000373368, ENST00000168148, ENST00000492481, | |
| Fusion gene scores | * DoF score | 7 X 3 X 9=189 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/189*10)=-0.918386234446348 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DGKD [Title/Abstract] AND SPP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DGKD | GO:0010033 | response to organic substance | 12200442 |
| Hgene | DGKD | GO:0051260 | protein homooligomerization | 12200442 |
| Tgene | SPP2 | GO:0006670 | sphingosine metabolic process | 12411432 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-28-2499-01A | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264057 | ENST00000373368 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| In-frame | ENST00000264057 | ENST00000168148 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| 5CDS-intron | ENST00000264057 | ENST00000492481 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| In-frame | ENST00000409813 | ENST00000373368 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| In-frame | ENST00000409813 | ENST00000168148 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| 5CDS-intron | ENST00000409813 | ENST00000492481 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| intron-3CDS | ENST00000489613 | ENST00000373368 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| intron-3CDS | ENST00000489613 | ENST00000168148 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| intron-intron | ENST00000489613 | ENST00000492481 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
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FusionProtFeatures for DGKD_SPP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DGKD | SPP2 |