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Fusion gene ID: 9824

FusionGeneSummary for DGKD_ATG16L1

Fusion gene summary

Fusion gene information	Fusion gene name: DGKD_ATG16L1
	Fusion gene ID: 9824
		Hgene	Tgene
	Gene symbol	DGKD	ATG16L1
	Gene ID	8527	55054
	Gene name	diacylglycerol kinase delta	autophagy related 16 like 1
	Synonyms	DGKdelta\|dgkd-2	APG16L\|ATG16A\|ATG16L\|IBD10\|WDR30
	Cytomap	2q37.1	2q37.1
	Type of gene	protein-coding	protein-coding
	Description	diacylglycerol kinase deltaDAG kinase deltaDGK-deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta	autophagy-related protein 16-1APG16L betaATG16 autophagy related 16-like 1WD repeat domain 30
	Modification date	20180519	20180529
	UniProtAcc	Q16760	Q676U5
	Ensembl transtripts involved in fusion gene	ENST00000264057, ENST00000409813, ENST00000489613,	ENST00000347464, ENST00000392017, ENST00000373525, ENST00000392020, ENST00000392018, ENST00000498620,
Fusion gene scores	* DoF score	7 X 3 X 9=189	2 X 2 X 2=8
	# samples	10	3
	** MAII score	log2(10/189*10)=-0.918386234446348 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/8*10)=1.90689059560852
Context	PubMed: DGKD [Title/Abstract] AND ATG16L1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DGKD	GO:0010033	response to organic substance	12200442
Hgene	DGKD	GO:0051260	protein homooligomerization	12200442

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-22-1017-01A	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
TCGA	RV	STAD	TCGA-BR-4369-01A	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000264057	ENST00000347464	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
Frame-shift	ENST00000264057	ENST00000392017	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
Frame-shift	ENST00000264057	ENST00000373525	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
Frame-shift	ENST00000264057	ENST00000392020	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
Frame-shift	ENST00000264057	ENST00000392018	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
5CDS-intron	ENST00000264057	ENST00000498620	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000409813	ENST00000347464	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000409813	ENST00000392017	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000409813	ENST00000373525	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000409813	ENST00000392020	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000409813	ENST00000392018	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-intron	ENST00000409813	ENST00000498620	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000489613	ENST00000347464	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000489613	ENST00000392017	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000489613	ENST00000373525	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000489613	ENST00000392020	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-3CDS	ENST00000489613	ENST00000392018	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
intron-intron	ENST00000489613	ENST00000498620	DGKD	chr2	234263320	+	ATG16L1	chr2	234164748	+
In-frame	ENST00000264057	ENST00000347464	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000264057	ENST00000392017	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000264057	ENST00000373525	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000264057	ENST00000392020	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000264057	ENST00000392018	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
5CDS-3UTR	ENST00000264057	ENST00000498620	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000409813	ENST00000347464	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000409813	ENST00000392017	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000409813	ENST00000373525	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000409813	ENST00000392020	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
In-frame	ENST00000409813	ENST00000392018	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
5CDS-3UTR	ENST00000409813	ENST00000498620	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
intron-3CDS	ENST00000489613	ENST00000347464	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
intron-3CDS	ENST00000489613	ENST00000392017	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
intron-3CDS	ENST00000489613	ENST00000373525	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
intron-3CDS	ENST00000489613	ENST00000392020	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
intron-3CDS	ENST00000489613	ENST00000392018	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+
intron-3UTR	ENST00000489613	ENST00000498620	DGKD	chr2	234299129	+	ATG16L1	chr2	234186214	+

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FusionProtFeatures for DGKD_ATG16L1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DGKD Q16760	ATG16L1 Q676U5

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Fusion gene ID: 9824

FusionGeneSummary for DGKD_ATG16L1

FusionProtFeatures for DGKD_ATG16L1